Accession
MI0015854
Symbol
HGNC:
MIR4324
Description
Homo sapiens
hsa-mir-4324 precursor miRNA
Summary
Caution, this is an AI generated summary based on literature. This may have errors. ?
MIR4324 is a microRNA whose expression in thyroid carcinoma patients had not been previously described before a recent study [PMC9221779]. This study found that MIR4324, along with other miRNAs, could enhance the diagnostic accuracy of fine-needle thyroid node biopsies, distinguishing malignant from benign thyroid nodules [PMC9221779]. Notably, a higher expression of MIR4324 is linked to papillary carcinoma that extends beyond the thyroid gland [PMC9221779]. The study revealed that an increase in MIR4324 expression significantly raises the likelihood of the disease being cancerous with metastasis [PMC9221779'>PMC9221779]. The diagnostic accuracy of MIR4324 was confirmed through ROC curve analysis, which showed it was effective in identifying patients with papillary thyroid carcinoma (PTC) [PMC9221779]. Furthermore, RT-PCR analysis confirmed higher relative expression levels of MIR4324 in PTC compared to benign nodules [PMC9221779]. Contrary to the original summary, the study actually found that patients with PTC with lymph node metastasis (LNM) had significantly higher levels of MIR4324 compared to those with PTC without LNM [PMC9221779], suggesting its potential role in assessing the risk and prognosis of thyroid carcinoma.
Sequence
31
reads,
22
reads per million, 9 experiments
cggccccuuuguuaagggucucagcuccagggaacuuuaaaaCCCUGAGACCCUAACCUUAAaggugcugca
((((.(((((((((.(((((((((.....((...........)))))))))))))))...))))).))))..
((((.(((((((((.(((((((((.....((...........)))))))))))))))...))))).))))..
Structure
-- c --- a cucca gaac cggc ccuuu guua gggucucag gg u |||| ||||| |||| ||||||||| || u gucg ggaAA CAAU CCCAGAGUC CC u ac u UUC - ----- aaaa
Annotation confidence
Not enough data
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Genome context
chr19: 49308797-49308868 [-]
Disease association
hsa-mir-4324 is associated with one or more human diseases in the Human microRNA Disease Database
| Disease | Description | Category | PubMed ID |
|---|
Database links
Mature hsa-miR-4324
| Accession | MIMAT0016876 |
| Description | Homo sapiens hsa-miR-4324 mature miRNA |
| Sequence | 43 - CCCUGAGACCCUAACCUUAA - 62 |
| Evidence |
experimental
SOLiD [1] |
| Database links |
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| Predicted targets |
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References
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