Stem-loop hsa-mir-3609

Accession

MI0015999

Symbol

HGNC: MIR3609

Description

Homo sapiens hsa-mir-3609 precursor miRNA

Summary

Caution, this is an AI generated summary based on literature. This may have errors.

MIR3609, a microRNA, has been identified as a potential biomarker for locally advanced breast cancer due to its downregulated expression [PMC9818474]. It contributes to the immune response against breast cancer by inhibiting the PD-L1 immune checkpoint, potentially enhancing the effectiveness of immune-mediated tumor cell clearance [PMC7527443]. MIR3609 can also bind to the 3′ UTR region of PD-L1 mRNA and reduce its expression, which may sensitize breast cancer cells to the chemotherapeutic agent doxorubicin [PMC9713762]. While the downregulation of MIR3609 and its precursor in cells with inhibited kalirin–GEF1 has been observed, it implies a regulatory mechanism that may lead to the upregulation of their target genes, which are involved in processes such as cell morphogenesis and neuron differentiation [PMC8017594, PMC9727336].'>PMC9727336].. Moreover, the upregulation of MIR3609 has been associated with increased sensitivity of breast cancer cells to Adriamycin, which is synonymous with doxorubicin [PMC9727336].

Literature search

1 open access papers mention hsa-mir-3609
(3 sentences)

Sequence

1446 reads, 416 reads per million, 78 experiments

guaacaguaacuuuuauucucauuuuccuuuucucuaccuuguagagaagCAAAGUGAUGAGUAAUACUGGCUGgagccc
((..((((.....(((((((((((((...(((((((((...))))))))).))))))).)))))).....))))..))..

Structure

--  aa    aacuu      -       ccu         c 
  gu  cagu     uuauuc ucauuuu   uuucucuac  
  ||  ||||     |||||| |||||||   ||||||||| u
  cg  GUCG     AAUGAG AGUGAAA   gaagagaug  
cc  ag    GUCAU      U       --C         u 

Annotation confidence Not enough data

Genome context

chr7: 98881650-98881729 [+]

Mature hsa-miR-3609

• Accession: MIMAT0017986
• Description: Homo sapiens hsa-miR-3609 mature miRNA
• Sequence: 51 - CAAAGUGAUGAGUAAUACUGGCUG - 74
• Evidence: experimental ; Illumina [1]

References

1. PubMed ID: 20459774
   Ultra-high throughput sequencing-based small RNA discovery and discrete statistical biomarker analysis in a collection of cervical tumours and matched controls
   Witten D, Tibshirani R, Gu SG, Fire A, Lui WO
   BMC Biol (2010) 8:58