Stem-loop hsa-mir-3613

Accession

MI0016003

Symbol

HGNC: MIR3613

Description

Homo sapiens hsa-mir-3613 precursor miRNA mir-3613

Gene
family

RF03323; mir-3613

Summary

Caution, this is an AI generated summary based on literature. This may have errors.

MIR3613 is a microRNA encoded by the MIR3613 gene, which is located on chromosome 13 near the tumor suppressor genes RB1 and BRCA2 [PMC7836180]. The deletion of MIR3613 has been observed in breast cancer (BC) genomes and is correlated with specific molecular subtypes, particularly showing an unfavorable prognosis in estrogen receptor-positive (ER+) BC patients [PMC8131824]. The deletion of MIR3613 has been associated with higher expression levels of stemness genes such as SOX2, NANOG, and LIN28B as well as cell cycle-related genes including CDC6, CDC25A, CDK1, ATM, E2F1, and MKI67 in BC patients [PMC7836180]. This genomic loss is more common in breast cancer subtypes with a poorer prognosis and less frequent in the luminal A subtype which has a comparatively favorable prognosis [PMC7836180]. Additionally, breast cancer samples with MIR3613 deletion exhibit decreased NEAT1 expression and increased SNHG16 expression [PMC7836180]. The study of TCGA breast cancer samples revealed that nearly 46% had deletions at the MIR3613 locus [PMC7836180]'>PMC7836180], indicating that such deletions are a common occurrence in BC. Despite these findings indicating an association between MIR3613 deletion and poor prognosis in ER+ BC patients specifically [PMC7836180], no significant correlation between MIR3613 copy number and survival was observed across the entire cohort or ER-negative subset of BC patients [PMC7836180].

Literature search

10 open access papers mention hsa-mir-3613
(23 sentences)

Sequence

10529 reads, 146 reads per million, 127 experiments

ugguuggguuuggauUGUUGUACUUUUUUUUUUGUUCguugcauuuuuaggaACAAAAAAAAAAGCCCAACCCUUCacaccacuuca
(((...(((.((((..((((..(((((((((((((((.(.........).)))))))))))))))..))))..)))).)))...)))

Structure

   uug   u    uU    UA               g ugc 
ugg   ggu ugga  GUUG  CUUUUUUUUUUGUUC u   a
|||   ||| ||||  ||||  ||||||||||||||| |   u
acu   cca aCUU  CAAC  GAAAAAAAAAACAag a   u
   uca   c    CC    CC               g uuu 

Annotation confidence High

Genome context

chr13: 49996415-49996501 [-]

Mature hsa-miR-3613-5p

• Accession: MIMAT0017990
• Description: Homo sapiens hsa-miR-3613-5p mature miRNA
• Sequence: 16 - UGUUGUACUUUUUUUUUUGUUC - 37
• Evidence: experimental ; Illumina [1]

Mature hsa-miR-3613-3p

• Accession: MIMAT0017991
• Description: Homo sapiens hsa-miR-3613-3p mature miRNA
• Sequence: 53 - ACAAAAAAAAAAGCCCAACCCUUC - 76
• Evidence: experimental ; Illumina [1]

References

1. PubMed ID: 20459774
   Ultra-high throughput sequencing-based small RNA discovery and discrete statistical biomarker analysis in a collection of cervical tumours and matched controls
   Witten D, Tibshirani R, Gu SG, Fire A, Lui WO
   BMC Biol (2010) 8:58