Accession
MI0017979
Symbol
HGNC:
MIR5090
Description
Homo sapiens
hsa-mir-5090 precursor miRNA
Summary
Caution, this is an AI generated summary based on literature. This may have errors. ?
MIR5090 is a nitrogen-responsive microRNA (miRNA) candidate in Arabidopsis that plays a role in nitrogen metabolism and adaptation to nitrogen starvation [PMC8539900]. It is involved in the regulation of glucosinolate synthesis, a process important for nitrogen homeostasis [PMC5258760]. MIR5090, along with other miRNAs such as miR826, has been studied for its relationship with nitrogen metabolism in Arabidopsis [PMC9551039]. It targets the gene ALKENYL HYDROXALKYL PRODUCING 2 (AOP2), which is involved in glucosinolate biosynthesis and is repressed by MIR5090 and miR826 under nitrogen starvation conditions [PMC7696010]. MIR5090 and miR826 may have evolved through inverted duplication of the genomic region containing AOP2, suggesting coevolution in response to nitrogen deprivation [PMC7696010]. AOP2 is confirmed as the common target of both MIR5090 and miR826 [PMC4468412]. Overexpression of MIR5090 or miR826 leads to enhanced tolerance to nitrogen limitation and improved growth under nitrogen-deficient conditions [PMC7758431] [PMC9538721]. These findings highlight the role of MIR5090 as a key regulator of nitrogen metabolism and adaptation to nutrient limitation in Arabidopsis.
Sequence
236
reads,
37
reads per million, 51 experiments
ucugagguacCCGGGGCAGAUUGGUGUAGGGUGcaaagccugcccgcccccuaagccuucugcccccaacuccagccugucagga
((((((((....((((((((..(((.(((((.((...........)).))))).))).))))))))........)))..))))).
((((((((....((((((((..(((.(((((.((...........)).))))).))).))))))))........)))..))))).
Structure
- -- ----acCC UU G U aaag ucuga ggu GGGGCAGA GGU UAGGG Gc c ||||| ||| |||||||| ||| ||||| || c ggacu ccg ccccgucu ccg auccc cg u a gu accucaac -u a c cccg
Annotation confidence
Not enough data
Do you think this miRNA is real?
Genome context
chr7: 102465742-102465826 [+]
Clustered miRNAs
1 other miRNA is < 10 kb from hsa-mir-5090
| Name | Accession | Chromosome | Start | End | Strand | Confidence |
|---|
Database links
Mature hsa-miR-5090
| Accession | MIMAT0021082 |
| Description | Homo sapiens hsa-miR-5090 mature miRNA |
| Sequence | 11 - CCGGGGCAGAUUGGUGUAGGGUG - 33 |
| Evidence |
experimental
Illumina [1], qPCR [1] |
| Database links |
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| Predicted targets |
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References
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