Accession
MI0017979
Symbol
HGNC:
MIR5090
Description
Homo sapiens
hsa-mir-5090 precursor miRNA
Summary
Caution, this is an AI generated summary based on literature. This may have errors. ?
MIR5090 is a microRNA (miRNA) in Arabidopsis thaliana that plays a crucial role in nitrogen (N) homeostasis and adaptation to N deficiency [PMC8539900]. It is coexpressed with miR826 and both target the ALKENYL HYDROXALKYL PRODUCING 2 (AOP2) gene, which is involved in glucosinolate synthesis, a nitrogen-containing metabolite [PMC5258760]. The overexpression of MIR5090 leads to improved N uptake and tolerance to N limitation, as it post-transcriptionally represses AOP2 expression under N starvation, thereby reallocating nitrogen to essential metabolites for plant survival [PMC8539900]. This miRNA is part of a regulatory network that includes other miRNAs such as miR160 and miR167, which are also responsive to N availability [PMC9551039]. MIR5090's induction under N deficiency suggests its role in the plant's adaptive response by modulating glucosinolate levels through AOP2 suppression [PMC7758431]. The coevolution of MIR5090 with its target gene AOP2 indicates a sophisticated adaptation mechanism for coping with nutrient stress [PMC7696010]. Transgenic Arabidopsis plants overexpressing MIR5090 exhibit better growth and delayed leaf yellowing under low nitrogen conditions, highlighting its potential for improving plant resilience to nutrient limitations [PMC9538721].
Sequence
236
reads,
37
reads per million, 51 experiments
ucugagguacCCGGGGCAGAUUGGUGUAGGGUGcaaagccugcccgcccccuaagccuucugcccccaacuccagccugucagga
((((((((....((((((((..(((.(((((.((...........)).))))).))).))))))))........)))..))))).
((((((((....((((((((..(((.(((((.((...........)).))))).))).))))))))........)))..))))).
Structure
- -- ----acCC UU G U aaag ucuga ggu GGGGCAGA GGU UAGGG Gc c ||||| ||| |||||||| ||| ||||| || c ggacu ccg ccccgucu ccg auccc cg u a gu accucaac -u a c cccg
Annotation confidence
Not enough data
Do you think this miRNA is real?
Genome context
chr7: 102465742-102465826 [+]
Clustered miRNAs
1 other miRNA is < 10 kb from hsa-mir-5090
| Name | Accession | Chromosome | Start | End | Strand | Confidence |
|---|
Database links
Mature hsa-miR-5090
| Accession | MIMAT0021082 |
| Description | Homo sapiens hsa-miR-5090 mature miRNA |
| Sequence | 11 - CCGGGGCAGAUUGGUGUAGGGUG - 33 |
| Evidence |
experimental
Illumina [1], qPCR [1] |
| Database links |
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| Predicted targets |
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References
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