Accession
MI0019116
Symbol
HGNC:
MIR5100
Description
Homo sapiens
hsa-mir-5100 precursor miRNA
Summary
Caution, this is an AI generated summary based on literature. This may have errors. ?
MIR5100 is a microRNA molecule that plays a significant role in the regulation of mouse bone marrow-derived mesenchymal stem cell (BMSC) proliferation and migration [PMC9391248]. Transfection of BMSCs with MIR5100 mimics resulted in changes in the level of transcripts involved in adhesion, migration, and IGF signaling [PMC9391248]. Additionally, MIR5100 upregulation in BMSCs led to the downregulation of MMP12 and IGFBP2 proteins [PMC9391248]. MIR5100 was also found to promote the proliferation and migration of lung cancer cells [PMC9391248'>PMC9391248'>PMC9391248'>PMC9391248]. In co-culture experiments, the presence of MIR5100-transfected BMSCs increased human myoblast fusion, which was dependent on IGFBP2 [PMC9391248]. Furthermore, MIR5100 downregulated TOB2 expression and promoted osteogenic differentiation of BMSCs [PMC9391248]. Microarray analysis revealed that MIR5100 modified the expression of transcripts involved in cellular movement and cell-to-cell signaling and interaction [PMC9391248]. The presence of MIR5100 mimics also led to significant changes in gene expression profiles [PMC9391248]. Overall, these findings highlight the role of MIR5100 in regulating cell proliferation, migration, fusion, and differentiation processes.
Literature search
4 open access papers mention hsa-mir-5100
(9 sentences)
(9 sentences)
Sequence
420
reads,
11
reads per million, 97 experiments
ccaugaggagcuggcagugggauggccuggggguaggagcguggcuucuggagcuagaccacaugggUUCAGAUCCCAGCGGUGCCUCUaacuggccacaggaccuugggcagucagcu
((....))(((((((.(((((.(((((((((((((...((.(((..((((((.(((.......))).))))))..)))))..))))))))...))))).....)))...)).)))))))
((....))(((((((.(((((.(((((((((((((...((.(((..((((((.(((.......))).))))))..)))))..))))))))...))))).....)))...)).)))))))
Structure
ccaugagg a --- ----a --- gga g cu g ga
agcuggc gu ggg uggcc ugggggua gc ugg ucugga cua c
||||||| || ||| ||||| |||||||| || ||| |||||| ||| c
ucgacug cg ucc accgg aUCUCCGU CG ACC AGACUU ggu a
-------- a ggu aggac uca -GG - CU g ac
Annotation confidence
Not enough data
Do you think this miRNA is real?
Genome context
chr10: 42997563-42997681 [+]
Disease association
hsa-mir-5100 is associated with one or more human diseases in the Human microRNA Disease Database
| Disease | Description | Category | PubMed ID |
|---|
Database links
Mature hsa-miR-5100
| Accession | MIMAT0022259 |
| Description | Homo sapiens hsa-miR-5100 mature miRNA |
| Sequence | 68 - UUCAGAUCCCAGCGGUGCCUCU - 89 |
| Evidence |
experimental
SOLiD [1] |
| Database links |
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| Predicted targets |
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References
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