Accession
MI0019116
Symbol
HGNC:
MIR5100
Description
Homo sapiens
hsa-mir-5100 precursor miRNA
Summary
Caution, this is an AI generated summary based on literature. This may have errors. ?
MIR5100 is a microRNA implicated in the regulation of various cellular processes in mouse bone marrow stromal cells (BMSCs) [PMC9391248]. It has been shown to play a significant role in the regulation of BMSC proliferation and migration [PMC9391248]. Transfection of BMSCs with MIR5100 mimics resulted in altered expression levels of transcripts related to adhesion, migration, and IGF signaling, with a notable downregulation of MMP12 and IGFBP2 proteins [PMC9391248]. MIR5100 also affects the fusion of human myoblasts in vitro, suggesting its role in cellular movement and interaction [PMC9391248'>PMC9391248'>PMC9391248]. Additionally, MIR5100 has been associated with the promotion of osteogenic differentiation by downregulating TOB2 expression [PMC9391248]. In cancer cells, MIR5100 is involved in proliferation and migration through mechanisms such as targeting TOB2 and activating SMAD2/3 signaling pathways [PMC9391248]. The microRNA's overexpression leads to significant changes in gene expression profiles within BMSCs, indicating its potential as a target for modulating cell behavior [PMC9391248].
Literature search
4 open access papers mention hsa-mir-5100
(9 sentences)
(9 sentences)
Sequence
420
reads,
11
reads per million, 97 experiments
ccaugaggagcuggcagugggauggccuggggguaggagcguggcuucuggagcuagaccacaugggUUCAGAUCCCAGCGGUGCCUCUaacuggccacaggaccuugggcagucagcu
((....))(((((((.(((((.(((((((((((((...((.(((..((((((.(((.......))).))))))..)))))..))))))))...))))).....)))...)).)))))))
((....))(((((((.(((((.(((((((((((((...((.(((..((((((.(((.......))).))))))..)))))..))))))))...))))).....)))...)).)))))))
Structure
ccaugagg a --- ----a --- gga g cu g ga
agcuggc gu ggg uggcc ugggggua gc ugg ucugga cua c
||||||| || ||| ||||| |||||||| || ||| |||||| ||| c
ucgacug cg ucc accgg aUCUCCGU CG ACC AGACUU ggu a
-------- a ggu aggac uca -GG - CU g ac
Annotation confidence
Not enough data
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Genome context
chr10: 42997563-42997681 [+]
Disease association
hsa-mir-5100 is associated with one or more human diseases in the Human microRNA Disease Database
| Disease | Description | Category | PubMed ID |
|---|
Database links
Mature hsa-miR-5100
| Accession | MIMAT0022259 |
| Description | Homo sapiens hsa-miR-5100 mature miRNA |
| Sequence | 68 - UUCAGAUCCCAGCGGUGCCUCU - 89 |
| Evidence |
experimental
SOLiD [1] |
| Database links |
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| Predicted targets |
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References
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