Stem-loop bta-mir-378b

Accession

MI0022279

Description

Bos taurus bta-mir-378b precursor miRNA

Summary

Caution, this is an AI generated summary based on literature. This may have errors.

Bta-mir-378b, a member of the miR-378 gene family, is implicated in regulating lipogenesis in adipose tissues and is down-regulated in multiple intestinal regions of super-shedders (SS), suggesting a role in altering lipid metabolism and immune functions, potentially affecting E. coli O157 interactions [PMC7959717]. This miRNA's down-regulation correlates with the negative regulation of PRDM1 and CYLD transcripts, which are associated with immune responses [PMC7959717]. The breadth of bta-mir-378b's influence is evident as it is down-regulated across all intestinal regions examined in SS cattle, with a varying number of negatively correlated transcripts ranging from two to 38 [PMC7959717]. The down-regulation pattern suggests bta-mir-378b may influence the expression of genes involved in immune defenses potentially affected by translocation of Gram-negative bacteria [PMC7959717]. Furthermore, bta-mir-378b's role as a key regulator is underscored by its consistent down-regulation across all intestinal regions studied and its association with differentially expressed genes between non-shedders (NS) and SS cattle [PMC7959717].

Literature search

24 open access papers mention bta-mir-378b
(101 sentences)

Sequence

914 reads, 286 reads per million, 67 experiments

cuggaccaccagggaaauccugauuuuguuucuuauuaaggggagguucaguauagagcaaacagcACUUGACUUGGAGUCAGAAGGCuuagguccaa
.((((((..((((.....)))).(((((((((...((((((....((((......))))......).)))))...)))).)))))......)))))).

Structure

c      accagggaaauccuga     -    uua     - --ggag    ag 
 uggacc                uuuug uuuc   uuaag g      guuc  u
 ||||||                ||||| ||||   ||||| |      ||||   
 accugg                AAGAC GAGG   AGUUC c      cgag  a
a      ----------auuCGG     U    UUC     A gacaaa    au 

Annotation confidence Not enough data

Genome context

chr15: 30904740-30904837 [+]

Mature bta-miR-378b

• Accession: MIMAT0025535
• Description: Bos taurus bta-miR-378b mature miRNA
• Sequence: 67 - ACUUGACUUGGAGUCAGAAGGC - 88
• Evidence: experimental ; Illumina [1]

References

1. PubMed ID: 21912509
   Solexa sequencing of novel and differentially expressed microRNAs in testicular and ovarian tissues in Holstein cattle
   "Huang J, Ju Z, Li Q, Hou Q, Wang C, Li J, Li R, Wang L, Sun T, Hang S, Gao Y, Hou M, Zhong J"
   "Int J Biol Sci (2011) 7:1016-1026