Stem-loop hsa-mir-8485

Accession

MI0027288

Symbol

HGNC: MIR8485

Description

Homo sapiens hsa-mir-8485 precursor miRNA

Summary

Caution, this is an AI generated summary based on literature. This may have errors.

MIR8485 is a microRNA (miRNA) that has been identified as one of the top three miRNAs related to the variance in mRNA expression between adult sham animals and young ones, suggesting a potential role in age-related molecular changes [PMC9748408]. In the context of cancer, MIR8485 is among the miRNAs found in exosomes derived from HCC827 cells that target genes within the p53 signaling pathway, which is crucial for cell cycle regulation and apoptosis [PMC9192438]. Mutations in MIR8485 have been associated with neurodegenerative processes through overexpression of neurexin 1 (NRXN1), which leads to presynaptic Ca2+ overload and mitochondrial dysfunction [PMC10014574]. Additionally, MIR8485 has been shown to influence autophagy by binding to LAMTOR3, subsequently reducing mTOR expression and enhancing autophagy markers ATG13 and LC3-II [PMC10102359]. This miRNA also appears among a list of 11 ranked miRNAs analyzed for target genes across the human genome, indicating its significance in gene regulation [PMC9338837].

Literature search

1 open access papers mention hsa-mir-8485
(1 sentences)

Sequence

2013 reads, 36534 reads per million, 118 experiments

ucugugauauacguguguguguguguguauauagcauauguguauacauacacacacacacacacacacaCACACACACACACACACGUAU
........((((((((((((((((((((..........(((((............)))))...........))))))))))))))))))))

Structure

ucugugau                    -auauagcaua     auaca 
        auacgugugugugugugugu           ugugu     u
        ||||||||||||||||||||           |||||      
        UAUGCACACACACACACACA           acaca     a
--------                    Cacacacacac     cacac 

Annotation confidence Not enough data

Genome context

chr2: 50696172-50696262 [-]

Disease association

hsa-mir-8485 is associated with one or more human diseases in the Human microRNA Disease Database

Mature hsa-miR-8485

• Accession: MIMAT0033692
• Description: Homo sapiens hsa-miR-8485 mature miRNA
• Sequence: 71 - CACACACACACACACACGUAU - 91
• Evidence: experimental ; RT-PCR [1]

References

1. PubMed ID: 23827811
   Transcriptome-wide analysis of TDP-43 binding small RNAs identifies miR-NID1 (miR-8485), a novel miRNA that represses NRXN1 expression
   "Fan Z, Chen X, Chen R"
   "Genomics (2014) 103:76-82