Stem-loop hsa-mir-8485

Accession

MI0027288

Symbol

HGNC: MIR8485

Description

Homo sapiens hsa-mir-8485 precursor miRNA

Summary

Caution, this is an AI generated summary based on literature. This may have errors.

MIR8485 is a non-coding RNA (ncRNA) that has been implicated in various biological processes and diseases [PMC9748408]. It has been identified as one of the top miRNAs associated with the number of mRNAs differing between adult and young animals [PMC9748408]. Additionally, MIR8485 has been found to be present in exosomes derived from HCC827 cells and is involved in the regulation of genes in the p53 signaling pathway [PMC9192438]. Mutations in MIR8485 have been linked to overexpression of neurexin 1 (NRXN1) and subsequent neurodegeneration [PMC10014574]. Furthermore, MIR8485 has been shown to bind to LAMTOR3, leading to modulation of mTOR expression and autophagy-related gene expression [PMC10102359]. In a search for miRNA targets, MIR8485 was among the 11 ranked miRNAs investigated for their potential targets among the human genome [PMC9338837].

Literature search

1 open access papers mention hsa-mir-8485
(1 sentences)

Sequence

2013 reads, 36534 reads per million, 118 experiments

ucugugauauacguguguguguguguguauauagcauauguguauacauacacacacacacacacacacaCACACACACACACACACGUAU
........((((((((((((((((((((..........(((((............)))))...........))))))))))))))))))))

Structure

ucugugau                    -auauagcaua     auaca 
        auacgugugugugugugugu           ugugu     u
        ||||||||||||||||||||           |||||      
        UAUGCACACACACACACACA           acaca     a
--------                    Cacacacacac     cacac 

Annotation confidence Not enough data

Genome context

chr2: 50696172-50696262 [-]

Disease association

hsa-mir-8485 is associated with one or more human diseases in the Human microRNA Disease Database

Mature hsa-miR-8485

• Accession: MIMAT0033692
• Description: Homo sapiens hsa-miR-8485 mature miRNA
• Sequence: 71 - CACACACACACACACACGUAU - 91
• Evidence: experimental ; RT-PCR [1]

References

1. PubMed ID: 23827811
   Transcriptome-wide analysis of TDP-43 binding small RNAs identifies miR-NID1 (miR-8485), a novel miRNA that represses NRXN1 expression
   "Fan Z, Chen X, Chen R"
   "Genomics (2014) 103:76-82