Stem-loop mmu-mir-199b

Accession

MI0000714

Symbol

MGI: Mir199b

Description

Mus musculus mmu-mir-199b precursor miRNA

Gene family

MIPF0000040; mir-199

Literature search

77 open access papers mention mmu-mir-199b
(385 sentences)

Sequence

3043807 reads, 15654 reads per million, 106 experiments

ccagaggauaccuccacuccgucuaCCCAGUGUUUAGACUACCUGUUCaggacucccaaauuguACAGUAGUCUGCACAUUGGUUAggcugggcuggguuagacccucgg
((.((((.....(((((((.(((((.(((((((.((((((((.(((.(((..........))).))))))))))).))))))).))))).))).))))......))))))

Structure

  a    -auacc    -   c     C       U        C   U   gacu 
cc gagg      ucca cuc gucua CCAGUGU UAGACUAC UGU Cag    c
|| ||||      |||| ||| ||||| ||||||| |||||||| ||| |||     
gg cucc      gggu ggg cggAU GGUUACA GUCUGAUG ACA guu    c
  -    cagauu    c   u     U       C        -   u   aaac 

Annotation confidence High

Comments

Mouse miR-199b is predicted based on homology with the previously identified human miR-199b (MIR:MI0000282) [1,2]. Landgraf et al. later showed that the 3' product is the predominant one [3].

Genome context

chr2: 32318460-32318569 [+]

Clustered miRNAs

1 other miRNA is < 10 kb from mmu-mir-199b

Mature mmu-miR-199b-5p

• Accession: MIMAT0000672
• Description: Mus musculus mmu-miR-199b-5p mature miRNA
• Sequence: 26 - CCCAGUGUUUAGACUACCUGUUC - 48
• Evidence: experimental ; cloned [3], Illumina [4-5]

Mature mmu-miR-199b-3p

• Accession: MIMAT0004667
• Description: Mus musculus mmu-miR-199b-3p mature miRNA
• Sequence: 65 - ACAGUAGUCUGCACAUUGGUUA - 86
• Evidence: experimental ; cloned [3], Illumina [4-5]

References

1. PubMed ID: 17604727
   A mammalian microRNA expression atlas based on small RNA library sequencing
   "Landgraf P, Rusu M, Sheridan R, Sewer A, Iovino N, Aravin A, Pfeffer S, Rice A, Kamphorst AO, Landthaler M, Lin C, Socci ND, Hermida L, Fulci V, Chiaretti S, Foa R, Schliwka J, Fuchs U, Novosel A, Muller RU, Schermer B, Bissels U, Inman J, Phan Q, Chien M"
   "Cell (2007) 129:1401-1414


2. PubMed ID: 12624257
   Vertebrate microRNA genes
   "Lim LP, Glasner ME, Yekta S, Burge CB, Bartel DP"
   "Science (2003) 299:1540


3. PubMed ID: 20215419
   MicroRNA transcriptome in the newborn mouse ovaries determined by massive parallel sequencing
   "Ahn HW, Morin RD, Zhao H, Harris RA, Coarfa C, Chen ZJ, Milosavljevic A, Marra MA, Rajkovic A"
   "Mol Hum Reprod (2010) 16:463-471


4. PubMed ID: 20413612
   Mammalian microRNAs: experimental evaluation of novel and previously annotated genes
   "Chiang HR, Schoenfeld LW, Ruby JG, Auyeung VC, Spies N, Baek D, Johnston WK, Russ C, Luo S, Babiarz JE, Blelloch R, Schroth GP, Nusbaum C, Bartel DP"
   "Genes Dev (2010) 24:992-1009


5. PubMed ID: 15634332
   New human and mouse microRNA genes found by homology search
   "Weber MJ"
   "FEBS J (2005) 272:59-73