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1 publications mentioning crm-mir-64a

Open access articles that are associated with the species Caenorhabditis remanei and mention the gene name mir-64a. Click the [+] symbols to view sentences that include the gene name, or the word cloud on the right for a summary.

[+] score: 32
Three of the six miRNAs conserved between C. remanei and C. elegans (mir-248, mir-784, and mir-787) are located on the X chromosome and five of them (mir-64, mir-248, mir-356, mir-784, and mir-787) regulate target genes enriched in gonad formation in C. elegans. [score:4]
Tandem duplicates and gene loss within the mir-64 cluster may modulate miRNA dosage to strengthen gene expression regulation according to species-specific needs (Doench and Sharp 2004). [score:4]
In addition, our analysis of the mir-64 cluster of miRNA genes further implicates mir-64c as a direct target of positive selection. [score:4]
Extensive sequence differences in the hairpin and in the mature sequences of mir-64 paralogs suggest possible subfunctionalization following their origin by duplication (fig. 7 B), although conservation of the seed in all members implies an overlapping set of target genes. [score:3]
Interestingly, the first ranked functional clusters of five miRNAs (mir-64, mir-248, mir-356, mir-784, and mir-787) are enriched for GO terms related to gonad development, although enrichment is significant only for mir-248, mir-356, and mir-787 after correction for multiple testing (supplementary table S5, online). [score:2]
We observed stronger differentiation between the Ohio and Ontario populations for two miRNAs in the cluster than is seen for 95% of loci in a reference set of coding genes (mir-64a and mir-64c; fig. 7) (Dey et al. 2012). [score:1]
We observed this process in the mir-64 cluster as an ongoing evolutionary dynamic between the closely related species C. remanei and C. latens, and within and between populations of C. remanei for three other miRNAs. [score:1]
Mature sequences of mir-64 homologs are well conserved between C. remanei and C. latens, with the exception of mir-64c homologs, which differ by up to three substitutions between the two species. [score:1]
We reconstructed the phylogenetic relationships among mature sequences of members of the mir-64 cluster in C. remanei, C. latens, C. elegans, C. briggsae, and C. brenneri using Neighbor-Joining with a maximum composite likelihood distance in MEGA 5, and assessed node confidence with 1,000 bootstrap replicates. [score:1]
Most variants are found in a single population and at low frequency, with noticeable exceptions for instance for SNPs in mir-64a, mir-248, mir-787, block2892, and block3297. [score:1]
To better understand the very recent evolution of the mir-64 cluster, we then examined the pattern of genetic differentiation of mir-64 miRNAs between populations of C. remanei. [score:1]
Moreover, eight miRNAs (block2890, block2892, block2981, block3297, mir-35i, mir-64a, mir-787, and mir-7606) have SNPs with minor allele frequency ≥25% in at least one population. [score:1]
We could not compare diversity between flanking sequences and miRNA hairpins for members of the mir-54 and mir-64 clusters. [score:1]
We identified an extra mir-64 copy within the C. latens mir-64 cluster based on sequence similarity with mir-64 homologs in C. latens and C. remanei, and typical minimum free energy stem-loop structure computed with the Vienna RNA server. [score:1]
The number of mir-64 paralogs differs between C. remanei and C. latens because of the possible loss of mir-64c-1 in C. remanei. [score:1]
We found that evolution of the mir-64 cluster is particularly dynamic. [score:1]
Nevertheless, we also showed extensive sequence divergence in the hairpin and mature sequences of mir-64 paralogs in both C. remanei and C. latens. [score:1]
However, the number of mir-64 paralogs varies up to 2-fold because of the independent gain and/or loss of tandem duplicates in different Caenorhabditis species. [score:1]
We also computed nucleotide divergence, with a maximum composite likelihood distance, among mir-64 homologs in C. remanei and C. latens separately for the mature and hairpin sequences. [score:1]
We included four additional strains of C. remanei (Japan; Tennessee, United States) and one of C. latens (JU724 from Zhouzhuang City, China) for analysis of the mir-64 cluster. [score:1]
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