Stem-loop hsa-mir-146a

Accession

MI0000477

Symbol

HGNC: MIR146A

Description

Homo sapiens hsa-mir-146a precursor miRNA

Literature search

749 open access papers mention hsa-mir-146a
(6781 sentences)

Sequence

319175 reads, 1682 reads per million, 137 experiments

ccgauguguauccucagcuuUGAGAACUGAAUUCCAUGGGUUgugucagugucagaCCUCUGAAAUUCAGUUCUUCAGcugggauaucucugucaucgu
.(((((.((((((.(((((..((((((((((((.((.(((((.((.......))))))).)).)))))))))))).)))))))))))......))))).

Structure

c     -----u      u     uU            C  U     g  uc 
 cgaug      guaucc cagcu  GAGAACUGAAUU CA GGGUU ug  a
 |||||      |||||| |||||  |||||||||||| || ||||| ||  g
 gcuac      uauagg gucGA  UUCUUGACUUAA GU UCCag ac  u
u     ugucuc      -     -C            A  C     -  ug 

Annotation confidence High

Comments

This miRNA sequence is predicted based on homology to a verified miRNA from mouse [1]. Its expression was later verified in human [2,3].

Genome context

chr5: 160485352-160485450 [+]

Disease association

hsa-mir-146a is associated with one or more human diseases in the Human microRNA Disease Database

Mature hsa-miR-146a-5p

• Accession: MIMAT0000449
• Description: Homo sapiens hsa-miR-146a-5p mature miRNA
• Sequence: 21 - UGAGAACUGAAUUCCAUGGGUU - 42
• Evidence: experimental ; cloned [2-3]

Mature hsa-miR-146a-3p

• Accession: MIMAT0004608
• Description: Homo sapiens hsa-miR-146a-3p mature miRNA
• Sequence: 57 - CCUCUGAAAUUCAGUUCUUCAG - 78
• Evidence: experimental ; cloned [3]

References

1. PubMed ID: 17604727
   A mammalian microRNA expression atlas based on small RNA library sequencing
   "Landgraf P, Rusu M, Sheridan R, Sewer A, Iovino N, Aravin A, Pfeffer S, Rice A, Kamphorst AO, Landthaler M, Lin C, Socci ND, Hermida L, Fulci V, Chiaretti S, Foa R, Schliwka J, Fuchs U, Novosel A, Muller RU, Schermer B, Bissels U, Inman J, Phan Q, Chien M"
   "Cell (2007) 129:1401-1414


2. PubMed ID: 12007417
   Identification of tissue-specific microRNAs from mouse
   "Lagos-Quintana M, Rauhut R, Yalcin A, Meyer J, Lendeckel W, Tuschl T"
   "Curr Biol (2002) 12:735-739


3. PubMed ID: 15800047
   Kaposi's sarcoma-associated herpesvirus expresses an array of viral microRNAs in latently infected cells
   "Cai X, Lu S, Zhang Z, Gonzalez CM, Damania B, Cullen BR"
   "Proc Natl Acad Sci U S A (2005) 102:5570-5575