Stem-loop dme-mir-2a-1

Accession

MI0000117

Description

Drosophila melanogaster dme-mir-2a-1 precursor miRNA

Literature search

29 open access papers mention dme-mir-2a-1
(190 sentences)

Sequence

551525 reads, 10548 reads per million, 49 experiments

gcugggCUCUCAAAGUGGUUGUGAAAUGcauuuccgcuuugcgcggcaUAUCACAGCCAGCUUUGAUGAGCuuagc
((((((((((((((((((((((((.((((.....(((.....))))))).))))))))).)))))).)))))))))

Structure

         -      -         A    auuuc   u 
gcugggCUC UCAAAG UGGUUGUGA AUGc     cgc u
||||||||| |||||| ||||||||| ||||     ||| u
cgauuCGAG AGUUUC ACCGACACU Uacg     gcg g
         U      G         A    -----   c 

Annotation confidence High

Comments

Stark et al. [2] have identified targets for miR-2 in Drosophila using computational prediction followed by experimental validation. miR-2 regulates the proapoptotic genes reaper, grim and sickle, suggesting that it may be involved in the control of apoptosis.

Genome context

chr2L: 19569897-19569972 [-]

Clustered miRNAs

2 other miRNAs are < 10 kb from dme-mir-2a-1

Mature dme-miR-2a-3p

• Accession: MIMAT0000106
• Description: Drosophila melanogaster dme-miR-2a-3p mature miRNA
• Sequence: 49 - UAUCACAGCCAGCUUUGAUGAGC - 71
• Evidence: experimental ; cloned [1,4], Northern [1,3], 454 [5-6], Illumina [6]

Mature dme-miR-2a-1-5p

• Accession: MIMAT0020780
• Description: Drosophila melanogaster dme-miR-2a-1-5p mature miRNA
• Sequence: 7 - CUCUCAAAGUGGUUGUGAAAUG - 28
• Evidence: not_experimental

References

1. PubMed ID: 11679670
   Identification of novel genes coding for small expressed RNAs
   "Lagos-Quintana M, Rauhut R, Lendeckel W, Tuschl T"
   "Science (2001) 294:853-858


2. PubMed ID: 12812784
   Temporal regulation of microRNA expression in Drosophila melanogaster mediated by hormonal signals and broad-Complex gene activity
   "Sempere LF, Sokol NS, Dubrovsky EB, Berger EM, Ambros V"
   "Dev Biol (2003) 259:9-18


3. PubMed ID: 12919683
   The small RNA profile during Drosophila melanogaster development
   "Aravin AA, Lagos-Quintana M, Yalcin A, Zavolan M, Marks D, Snyder B, Gaasterland T, Meyer J, Tuschl T"
   "Dev Cell (2003) 5:337-350


4. PubMed ID: 17989254
   Evolution, biogenesis, expression, and target predictions of a substantially expanded set of Drosophila microRNAs
   "Ruby JG, Stark A, Johnston WK, Kellis M, Bartel DP, Lai EC"
   "Genome Res (2007) 17:1850-1864


5. PubMed ID: 17989255
   Systematic discovery and characterization of fly microRNAs using 12 Drosophila genomes
   "Stark A, Kheradpour P, Parts L, Brennecke J, Hodges E, Hannon GJ, Kellis M"
   "Genome Res (2007) 17:1865-1879


6. PubMed ID: 14691535
   Identification of Drosophila MicroRNA targets
   "Stark A, Brennecke J, Russell RB, Cohen SM"
   "PLoS Biol (2003) 1:E60