miRBase entry: mmu-mir-30a

Stem-loop mmu-mir-30a


Accession
MI0000144
Symbol
MGI: Mir30a
Description
Mus musculus mmu-mir-30a precursor miRNA
Gene family
MIPF0000005; mir-30

Literature search
231 open access papers mention mmu-mir-30a
(1596 sentences)

Sequence

4925552 reads, 6204 reads per million, 107 experiments
gcgacUGUAAACAUCCUCGACUGGAAGcugugaagccacaaaugggCUUUCAGUCGGAUGUUUGCAGCugc
(((.((((((((((((..((((((((((((((....))).....))))))))))))))))))))))).)))

Structure
   a            UC           -----   a 
gcg cUGUAAACAUCC  GACUGGAAGcu     gug a
||| ||||||||||||  |||||||||||     |||  
cgu GACGUUUGUAGG  CUGACUUUCgg     cac g
   C            --           guaaa   c 


Annotation confidence High
Do you think this miRNA is real?
Comments
Landgraf et al. confirm that the 5' mature miRNA product is the predominant one [4].

Genome context
chr1: 23272269-23272339 [+]

Database links

Mature mmu-miR-30a-5p

Accession MIMAT0000128
Description Mus musculus mmu-miR-30a-5p mature miRNA
Sequence 6 - UGUAAACAUCCUCGACUGGAAG - 27
Evidence experimental
cloned [1-2,4], Illumina [5-6]
Database links
Predicted targets

Mature mmu-miR-30a-3p

Accession MIMAT0000129
Description Mus musculus mmu-miR-30a-3p mature miRNA
Sequence 47 - CUUUCAGUCGGAUGUUUGCAGC - 68
Evidence experimental
cloned [1,3-4], Illumina [5-6]
Database links
Predicted targets

References

  1. PubMed ID: 17604727
    A mammalian microRNA expression atlas based on small RNA library sequencing
    "Landgraf P, Rusu M, Sheridan R, Sewer A, Iovino N, Aravin A, Pfeffer S, Rice A, Kamphorst AO, Landthaler M, Lin C, Socci ND, Hermida L, Fulci V, Chiaretti S, Foa R, Schliwka J, Fuchs U, Novosel A, Muller RU, Schermer B, Bissels U, Inman J, Phan Q, Chien M"
    "Cell (2007) 129:1401-1414

  2. PubMed ID: 12007417
    Identification of tissue-specific microRNAs from mouse
    "Lagos-Quintana M, Rauhut R, Yalcin A, Meyer J, Lendeckel W, Tuschl T"
    "Curr Biol (2002) 12:735-739

  3. PubMed ID: 15538371
    A pancreatic islet-specific microRNA regulates insulin secretion
    "Poy MN, Eliasson L, Krutzfeldt J, Kuwajima S, Ma X, Macdonald PE, Pfeffer S, Tuschl T, Rajewsky N, Rorsman P, Stoffel M"
    "Nature (2004) 432:226-230

  4. PubMed ID: 16766679
    Identification and characterization of two novel classes of small RNAs in the mouse germline: retrotransposon-derived siRNAs in oocytes and germline small RNAs in testes
    "Watanabe T, Takeda A, Tsukiyama T, Mise K, Okuno T, Sasaki H, Minami N, Imai H"
    "Genes Dev (2006) 20:1732-1743

  5. PubMed ID: 20215419
    MicroRNA transcriptome in the newborn mouse ovaries determined by massive parallel sequencing
    "Ahn HW, Morin RD, Zhao H, Harris RA, Coarfa C, Chen ZJ, Milosavljevic A, Marra MA, Rajkovic A"
    "Mol Hum Reprod (2010) 16:463-471

  6. PubMed ID: 20413612
    Mammalian microRNAs: experimental evaluation of novel and previously annotated genes
    "Chiang HR, Schoenfeld LW, Ruby JG, Auyeung VC, Spies N, Baek D, Johnston WK, Russ C, Luo S, Babiarz JE, Blelloch R, Schroth GP, Nusbaum C, Bartel DP"
    "Genes Dev (2010) 24:992-1009