miRBase entry: mmu-mir-125b-2

Stem-loop mmu-mir-125b-2


Accession
MI0000152
Symbol
MGI: Mir125b-2
Description
Mus musculus mmu-mir-125b-2 precursor miRNA
Gene family
MIPF0000033; mir-10

Literature search
260 open access papers mention mmu-mir-125b-2
(1514 sentences)

Sequence

1708266 reads, 10671 reads per million, 104 experiments
gccuagUCCCUGAGACCCUAACUUGUGAgguauuuuaguaacaucACAAGUCAGGUUCUUGGGACCUaggc
((((((((((.((((.(((.((((((((.((.........)).)))))))).))).)))))))).))))))

Structure
      -    U    C   A        g  auu 
gccuag UCCC GAGA CCU ACUUGUGA gu   u
|||||| |||| |||| ||| |||||||| ||   u
cggaUC AGGG UUCU GGA UGAACAcu ca   a
      C    -    U   C        a  aug 


Annotation confidence High
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Comments
Mouse miR-125b was cloned from mouse brain tissues in [1]. There are 2 predicted hairpin precursor structures in the mouse genome, each has a closely related human homologue [2] (mir-125b-1, MIR:MI0000725; mir-125b-2, MIR:MI0000152; the latter was previously named mir-125b here).

Genome context
chr16: 77646273-77646343 [+]

Database links

Mature mmu-miR-125b-5p

Accession MIMAT0000136
Description Mus musculus mmu-miR-125b-5p mature miRNA
Sequence 7 - UCCCUGAGACCCUAACUUGUGA - 28
Evidence experimental
cloned [1,3-4], Illumina [5-6]
Database links
Predicted targets

Mature mmu-miR-125b-2-3p

Accession MIMAT0004529
Description Mus musculus mmu-miR-125b-2-3p mature miRNA
Sequence 46 - ACAAGUCAGGUUCUUGGGACCU - 67
Evidence experimental
cloned [4], Illumina [5-6]
Database links
Predicted targets

References

  1. PubMed ID: 17604727
    A mammalian microRNA expression atlas based on small RNA library sequencing
    "Landgraf P, Rusu M, Sheridan R, Sewer A, Iovino N, Aravin A, Pfeffer S, Rice A, Kamphorst AO, Landthaler M, Lin C, Socci ND, Hermida L, Fulci V, Chiaretti S, Foa R, Schliwka J, Fuchs U, Novosel A, Muller RU, Schermer B, Bissels U, Inman J, Phan Q, Chien M"
    "Cell (2007) 129:1401-1414

  2. PubMed ID: 12007417
    Identification of tissue-specific microRNAs from mouse
    "Lagos-Quintana M, Rauhut R, Yalcin A, Meyer J, Lendeckel W, Tuschl T"
    "Curr Biol (2002) 12:735-739

  3. PubMed ID: 16766679
    Identification and characterization of two novel classes of small RNAs in the mouse germline: retrotransposon-derived siRNAs in oocytes and germline small RNAs in testes
    "Watanabe T, Takeda A, Tsukiyama T, Mise K, Okuno T, Sasaki H, Minami N, Imai H"
    "Genes Dev (2006) 20:1732-1743

  4. PubMed ID: 20215419
    MicroRNA transcriptome in the newborn mouse ovaries determined by massive parallel sequencing
    "Ahn HW, Morin RD, Zhao H, Harris RA, Coarfa C, Chen ZJ, Milosavljevic A, Marra MA, Rajkovic A"
    "Mol Hum Reprod (2010) 16:463-471

  5. PubMed ID: 20413612
    Mammalian microRNAs: experimental evaluation of novel and previously annotated genes
    "Chiang HR, Schoenfeld LW, Ruby JG, Auyeung VC, Spies N, Baek D, Johnston WK, Russ C, Luo S, Babiarz JE, Blelloch R, Schroth GP, Nusbaum C, Bartel DP"
    "Genes Dev (2010) 24:992-1009

  6. PubMed ID: 15634332
    New human and mouse microRNA genes found by homology search
    "Weber MJ"
    "FEBS J (2005) 272:59-73