miRBase entry: mmu-mir-126a

Stem-loop mmu-mir-126a


Accession
MI0000153
Symbol
MGI: Mir126a
Description
Mus musculus mmu-mir-126a precursor miRNA
Gene family
MIPF0000115; mir-126

Literature search
206 open access papers mention mmu-mir-126a
(1850 sentences)

Sequence

1656118 reads, 6917 reads per million, 100 experiments
ugacagcaCAUUAUUACUUUUGGUACGCGcugugacacuucaaacUCGUACCGUGAGUAAUAAUGCGcgguca
((((.((.(((((((((((.(((((((.....(((....)))....))))))).))))))))))).)).))))

Structure
    a  a           U       CGcug   c 
ugac gc CAUUAUUACUU UGGUACG     uga a
|||| || ||||||||||| |||||||     |||  
acug cG GUAAUAAUGAG GCCAUGC     acu c
    g  C           U       -Ucaa   u 


Annotation confidence High
Do you think this miRNA is real?
Comments
miR-123 identified in [1] was later found to originate from the same precursor as miR-126 and was hence renamed miR-126-5p.

Genome context
chr2: 26591357-26591429 [+]
Clustered miRNAs
1 other miRNA is < 10 kb from mmu-mir-126a
Name Accession Chromosome Start End Strand Confidence




Database links

Mature mmu-miR-126a-5p

Accession MIMAT0000137
Description Mus musculus mmu-miR-126a-5p mature miRNA
Sequence 9 - CAUUAUUACUUUUGGUACGCG - 29
Evidence experimental
cloned [1-2,4], Illumina [5-6]
Database links
Predicted targets

Mature mmu-miR-126a-3p

Accession MIMAT0000138
Description Mus musculus mmu-miR-126a-3p mature miRNA
Sequence 46 - UCGUACCGUGAGUAAUAAUGCG - 67
Evidence experimental
cloned [1,3-4], Illumina [5-6]
Database links
Predicted targets

References

  1. PubMed ID: 17604727
    A mammalian microRNA expression atlas based on small RNA library sequencing
    "Landgraf P, Rusu M, Sheridan R, Sewer A, Iovino N, Aravin A, Pfeffer S, Rice A, Kamphorst AO, Landthaler M, Lin C, Socci ND, Hermida L, Fulci V, Chiaretti S, Foa R, Schliwka J, Fuchs U, Novosel A, Muller RU, Schermer B, Bissels U, Inman J, Phan Q, Chien M"
    "Cell (2007) 129:1401-1414

  2. PubMed ID: 12007417
    Identification of tissue-specific microRNAs from mouse
    "Lagos-Quintana M, Rauhut R, Yalcin A, Meyer J, Lendeckel W, Tuschl T"
    "Curr Biol (2002) 12:735-739

  3. PubMed ID: 15538371
    A pancreatic islet-specific microRNA regulates insulin secretion
    "Poy MN, Eliasson L, Krutzfeldt J, Kuwajima S, Ma X, Macdonald PE, Pfeffer S, Tuschl T, Rajewsky N, Rorsman P, Stoffel M"
    "Nature (2004) 432:226-230

  4. PubMed ID: 16766679
    Identification and characterization of two novel classes of small RNAs in the mouse germline: retrotransposon-derived siRNAs in oocytes and germline small RNAs in testes
    "Watanabe T, Takeda A, Tsukiyama T, Mise K, Okuno T, Sasaki H, Minami N, Imai H"
    "Genes Dev (2006) 20:1732-1743

  5. PubMed ID: 20215419
    MicroRNA transcriptome in the newborn mouse ovaries determined by massive parallel sequencing
    "Ahn HW, Morin RD, Zhao H, Harris RA, Coarfa C, Chen ZJ, Milosavljevic A, Marra MA, Rajkovic A"
    "Mol Hum Reprod (2010) 16:463-471

  6. PubMed ID: 20413612
    Mammalian microRNAs: experimental evaluation of novel and previously annotated genes
    "Chiang HR, Schoenfeld LW, Ruby JG, Auyeung VC, Spies N, Baek D, Johnston WK, Russ C, Luo S, Babiarz JE, Blelloch R, Schroth GP, Nusbaum C, Bartel DP"
    "Genes Dev (2010) 24:992-1009