Stem-loop mmu-mir-126a

Accession

MI0000153

Symbol

MGI: Mir126a

Description

Mus musculus mmu-mir-126a precursor miRNA mir-126

Gene
family

RF00701; mir-126

Literature search

206 open access papers mention mmu-mir-126a
(1850 sentences)

Sequence

1656075 reads, 4491 reads per million, 100 experiments

ugacagcaCAUUAUUACUUUUGGUACGCGcugugacacuucaaacUCGUACCGUGAGUAAUAAUGCGcgguca
((((.((.(((((((((((.(((((((.....(((....)))....))))))).))))))))))).)).))))

Structure

    a  a           U       CGcug   c 
ugac gc CAUUAUUACUU UGGUACG     uga a
|||| || ||||||||||| |||||||     |||  
acug cG GUAAUAAUGAG GCCAUGC     acu c
    g  C           U       -Ucaa   u 

Annotation confidence High

Comments

miR-123 identified in [1] was later found to originate from the same precursor as miR-126 and was hence renamed miR-126-5p.

Genome context

chr2: 26591357-26591429 [+]

Clustered miRNAs

1 other miRNA is < 10 kb from mmu-mir-126a

Mature mmu-miR-126a-5p

• Accession: MIMAT0000137
• Description: Mus musculus mmu-miR-126a-5p mature miRNA
• Sequence: 9 - CAUUAUUACUUUUGGUACGCG - 29
• Evidence: experimental ; cloned [1-2,4], Illumina [5-6]

Mature mmu-miR-126a-3p

• Accession: MIMAT0000138
• Description: Mus musculus mmu-miR-126a-3p mature miRNA
• Sequence: 46 - UCGUACCGUGAGUAAUAAUGCG - 67
• Evidence: experimental ; cloned [1,3-4], Illumina [5-6]

References

1. PubMed ID: 17604727
   A mammalian microRNA expression atlas based on small RNA library sequencing
   "Landgraf P, Rusu M, Sheridan R, Sewer A, Iovino N, Aravin A, Pfeffer S, Rice A, Kamphorst AO, Landthaler M, Lin C, Socci ND, Hermida L, Fulci V, Chiaretti S, Foa R, Schliwka J, Fuchs U, Novosel A, Muller RU, Schermer B, Bissels U, Inman J, Phan Q, Chien M"
   "Cell (2007) 129:1401-1414


2. PubMed ID: 12007417
   Identification of tissue-specific microRNAs from mouse
   "Lagos-Quintana M, Rauhut R, Yalcin A, Meyer J, Lendeckel W, Tuschl T"
   "Curr Biol (2002) 12:735-739


3. PubMed ID: 15538371
   A pancreatic islet-specific microRNA regulates insulin secretion
   "Poy MN, Eliasson L, Krutzfeldt J, Kuwajima S, Ma X, Macdonald PE, Pfeffer S, Tuschl T, Rajewsky N, Rorsman P, Stoffel M"
   "Nature (2004) 432:226-230


4. PubMed ID: 16766679
   Identification and characterization of two novel classes of small RNAs in the mouse germline: retrotransposon-derived siRNAs in oocytes and germline small RNAs in testes
   "Watanabe T, Takeda A, Tsukiyama T, Mise K, Okuno T, Sasaki H, Minami N, Imai H"
   "Genes Dev (2006) 20:1732-1743


5. PubMed ID: 20215419
   MicroRNA transcriptome in the newborn mouse ovaries determined by massive parallel sequencing
   "Ahn HW, Morin RD, Zhao H, Harris RA, Coarfa C, Chen ZJ, Milosavljevic A, Marra MA, Rajkovic A"
   "Mol Hum Reprod (2010) 16:463-471


6. PubMed ID: 20413612
   Mammalian microRNAs: experimental evaluation of novel and previously annotated genes
   "Chiang HR, Schoenfeld LW, Ruby JG, Auyeung VC, Spies N, Baek D, Johnston WK, Russ C, Luo S, Babiarz JE, Blelloch R, Schroth GP, Nusbaum C, Bartel DP"
   "Genes Dev (2010) 24:992-1009