miRBase entry: mmu-mir-140

Stem-loop mmu-mir-140


Accession
MI0000165
Symbol
MGI: Mir140
Description
Mus musculus mmu-mir-140 precursor miRNA
Gene family
MIPF0000085; mir-140

Summary
Caution, this is an AI generated summary based on literature. This may have errors. ?

Mmu-mir-140 is a microRNA that has been found to suppress IL-6 translation by binding to the 3′UTR of IL-6 mRNA, potentially mediating the function of Rb in suppressing tumor progression [PMC5355146]. In a study, 11 up-regulated miRNAs and 10 down-regulated miRNAs were significantly associated with EMF exposure-time product in donors 2 and 3, respectively [PMC7904780]. An interaction network was constructed using the Cytoscape software, which included mmu-mir-140, potential target genes Smad3, Cxcl12, and Hdac4, as well as potential target gene-involved GO terms and KEGG pathways [PMC9218872]. Both forms of mmu-mir-140 were found to influence the healing process at a certain stage [PMC6641081]. In order to identify genes targeted by mmu-mir-140, a search was conducted using microRNA.org [PMC5355146].

In summary, mmu-mir-140 is a microRNA that has been shown to suppress IL-6 translation and potentially mediate Rb function in suppressing tumor progression. It has also been associated with EMF exposure-time product and found to influence the healing process. An interaction network involving mmu-mir-140 and potential target genes has been constructed. Additionally, genes targeted by mmu-mir-140 have been identified through a search on microRNA.org.

Literature search
88 open access papers mention mmu-mir-140
(916 sentences)

Sequence

7001290 reads, 17279 reads per million, 107 experiments
ccugcCAGUGGUUUUACCCUAUGGUAGguuacgucaugcuguucUACCACAGGGUAGAACCACGGacagg
((((((.(((((((((((((.(((((((.((.((...)))).))))))).))))))))))))))).))))

Structure
    -  A             A       u  c  c 
ccug cC GUGGUUUUACCCU UGGUAGg ua gu  
|||| || ||||||||||||| ||||||| || || a
ggac GG CACCAAGAUGGGA ACCAUcu gu cg  
    a  -             C       u  -  u 


Annotation confidence High
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Genome context
chr8: 107551244-107551313 [+]

Database links

Mature mmu-miR-140-5p

Accession MIMAT0000151
Description Mus musculus mmu-miR-140-5p mature miRNA
Sequence 6 - CAGUGGUUUUACCCUAUGGUAG - 27
Evidence experimental
cloned [1-4], Illumina [5-6]
Database links
Predicted targets

Mature mmu-miR-140-3p

Accession MIMAT0000152
Description Mus musculus mmu-miR-140-3p mature miRNA
Sequence 45 - UACCACAGGGUAGAACCACGG - 65
Evidence experimental
cloned [2,4], Illumina [5-6]
Database links
Predicted targets

References

  1. PubMed ID: 17604727
    A mammalian microRNA expression atlas based on small RNA library sequencing
    "Landgraf P, Rusu M, Sheridan R, Sewer A, Iovino N, Aravin A, Pfeffer S, Rice A, Kamphorst AO, Landthaler M, Lin C, Socci ND, Hermida L, Fulci V, Chiaretti S, Foa R, Schliwka J, Fuchs U, Novosel A, Muller RU, Schermer B, Bissels U, Inman J, Phan Q, Chien M"
    "Cell (2007) 129:1401-1414

  2. PubMed ID: 12007417
    Identification of tissue-specific microRNAs from mouse
    "Lagos-Quintana M, Rauhut R, Yalcin A, Meyer J, Lendeckel W, Tuschl T"
    "Curr Biol (2002) 12:735-739

  3. PubMed ID: 15538371
    A pancreatic islet-specific microRNA regulates insulin secretion
    "Poy MN, Eliasson L, Krutzfeldt J, Kuwajima S, Ma X, Macdonald PE, Pfeffer S, Tuschl T, Rajewsky N, Rorsman P, Stoffel M"
    "Nature (2004) 432:226-230

  4. PubMed ID: 16766679
    Identification and characterization of two novel classes of small RNAs in the mouse germline: retrotransposon-derived siRNAs in oocytes and germline small RNAs in testes
    "Watanabe T, Takeda A, Tsukiyama T, Mise K, Okuno T, Sasaki H, Minami N, Imai H"
    "Genes Dev (2006) 20:1732-1743

  5. PubMed ID: 20215419
    MicroRNA transcriptome in the newborn mouse ovaries determined by massive parallel sequencing
    "Ahn HW, Morin RD, Zhao H, Harris RA, Coarfa C, Chen ZJ, Milosavljevic A, Marra MA, Rajkovic A"
    "Mol Hum Reprod (2010) 16:463-471

  6. PubMed ID: 20413612
    Mammalian microRNAs: experimental evaluation of novel and previously annotated genes
    "Chiang HR, Schoenfeld LW, Ruby JG, Auyeung VC, Spies N, Baek D, Johnston WK, Russ C, Luo S, Babiarz JE, Blelloch R, Schroth GP, Nusbaum C, Bartel DP"
    "Genes Dev (2010) 24:992-1009