miRBase entry: mmu-mir-10b

Stem-loop mmu-mir-10b


Accession
MI0000221
Symbol
MGI: Mir10b
Description
Mus musculus mmu-mir-10b precursor miRNA
Gene family
MIPF0000033; mir-10

Literature search
133 open access papers mention mmu-mir-10b
(861 sentences)

Sequence

13785945 reads, 36228 reads per million, 97 experiments
uauaUACCCUGUAGAACCGAAUUUGUGugguacccacauagucaCAGAUUCGAUUCUAGGGGAAUAua
(((((.((((.(((((.(((((((((((((...))))......))))))))).))))))))).)))))

Structure
     A    G     C         ------    u 
uauaU CCCU UAGAA CGAAUUUGU      Gugg  
||||| |||| ||||| |||||||||      |||| a
auAUA GGGG AUCUU GCUUAGACa      cacc  
     A    -     A         cugaua    c 


Annotation confidence Not enough data
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Comments
The sequence of mouse miR-10b, as reported by Lagos-Quintana et al. [1], is offset by 2 nt in the 3' direction with respect to sequences cloned from human (MIR:MI0000267) and zebrafish (MIR:MI0001364). The mature sequence shown here represents the most commonly cloned form from large-scale cloning studies [2]. The 5' end of the miRNA may be offset with respect to previous annotations.

Genome context
chr2: 74726070-74726137 [+]

Database links

Mature mmu-miR-10b-5p

Accession MIMAT0000208
Description Mus musculus mmu-miR-10b-5p mature miRNA
Sequence 5 - UACCCUGUAGAACCGAAUUUGUG - 27
Evidence experimental
cloned [1-2], Illumina [3-4]
Database links
Predicted targets

Mature mmu-miR-10b-3p

Accession MIMAT0004538
Description Mus musculus mmu-miR-10b-3p mature miRNA
Sequence 45 - CAGAUUCGAUUCUAGGGGAAUA - 66
Evidence experimental
cloned [2], Illumina [3-4]
Database links
Predicted targets

References

  1. PubMed ID: 17604727
    A mammalian microRNA expression atlas based on small RNA library sequencing
    "Landgraf P, Rusu M, Sheridan R, Sewer A, Iovino N, Aravin A, Pfeffer S, Rice A, Kamphorst AO, Landthaler M, Lin C, Socci ND, Hermida L, Fulci V, Chiaretti S, Foa R, Schliwka J, Fuchs U, Novosel A, Muller RU, Schermer B, Bissels U, Inman J, Phan Q, Chien M"
    "Cell (2007) 129:1401-1414

  2. PubMed ID: 12554859
    New microRNAs from mouse and human
    "Lagos-Quintana M, Rauhut R, Meyer J, Borkhardt A, Tuschl T"
    "RNA (2003) 9:175-179

  3. PubMed ID: 20215419
    MicroRNA transcriptome in the newborn mouse ovaries determined by massive parallel sequencing
    "Ahn HW, Morin RD, Zhao H, Harris RA, Coarfa C, Chen ZJ, Milosavljevic A, Marra MA, Rajkovic A"
    "Mol Hum Reprod (2010) 16:463-471

  4. PubMed ID: 20413612
    Mammalian microRNAs: experimental evaluation of novel and previously annotated genes
    "Chiang HR, Schoenfeld LW, Ruby JG, Auyeung VC, Spies N, Baek D, Johnston WK, Russ C, Luo S, Babiarz JE, Blelloch R, Schroth GP, Nusbaum C, Bartel DP"
    "Genes Dev (2010) 24:992-1009