miRBase entry: mmu-mir-122

Stem-loop mmu-mir-122


Accession
MI0000256
Symbol
MGI: Mir122
Description
Mus musculus mmu-mir-122 precursor miRNA
Gene family
MIPF0000095; mir-122

Summary
Caution, this is an AI generated summary based on literature. This may have errors. ?

A study using mouse models for non-alcoholic fatty liver disease (NAFLD) found that liver cells exposed to excessive lipids released higher numbers of exosomes containing higher amounts of mmu-mir-122 and mmu-miR-192 [PMC7936154]. The motif corresponding to the seed of mmu-mir-122 was significantly overrepresented in the 3′UTRs of upregulated genes and underrepresented in the 3′UTRs of downregulated genes [PMC2820085]. Inhibition of mmu-mir-122 was found to be the primary cause for up-regulation of 372 genes, with 11% of these genes predicted to contain a perfect 8-mer binding site for mmu-mir-122 [PMC3125776]. In mice infected with S. japonicum, serum levels of mmu-miR-21, mmu-mir-122, and mmumiR-34a were significantly higher [PMC9650547]. Treatment with PB decreased hepatic levels of mmu-mir-122 in mice [PMC3399820]. Kupffer cells were found to express specific miRNAs including mmu-mir-122 [PMC8652219]. The expression levels of miR-122 were measured using real-time RT-qPCR and TaqMan assays [PMC3399820][PMC8652219][PMC8935237][PMC4569899[PMC8652219][PMC8935237][PMC4569899]. Transfection with an anti-sense oligonucleotide inhibitor increased mRNA expression levels for six genes including GYS1, SLC7A1, MINK1, ALDOA, CCNG1, and P4HA1 in a mouse hepatocyte-derived cell line [PMC5415838]. Down-regulation of mmu-mir-122 during high-fat diet (HFD)-induced obesity was observed in mice [PMC3319598]. Mmu-mir-122 is mainly expressed in the liver and constitutes 70% of all liver miRNAs [PMC3319598].

Literature search
264 open access papers mention mmu-mir-122
(2448 sentences)

Sequence

3057648 reads, 6121 reads per million, 92 experiments
agcugUGGAGUGUGACAAUGGUGUUUGuguccaaaccaucAAACGCCAUUAUCACACUAAAUagcu
((((((..(((((((.(((((((((((((.......)).))))))))))).)))))))..))))))

Structure
      GG       C           -  uc 
agcugU  AGUGUGA AAUGGUGUUUG ug  c
||||||  ||||||| ||||||||||| ||  a
ucgaUA  UCACACU UUACCGCAAAc ac  a
      AA       A           u  ca 


Annotation confidence High
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Genome context
chr18: 65248861-65248926 [+]
Clustered miRNAs
1 other miRNA is < 10 kb from mmu-mir-122
Name Accession Chromosome Start End Strand Confidence




Database links

Mature mmu-miR-122-5p

Accession MIMAT0000246
Description Mus musculus mmu-miR-122-5p mature miRNA
Sequence 6 - UGGAGUGUGACAAUGGUGUUUG - 27
Evidence experimental
cloned [1-2], Illumina [3-4]
Database links
Predicted targets

Mature mmu-miR-122-3p

Accession MIMAT0017005
Description Mus musculus mmu-miR-122-3p mature miRNA
Sequence 41 - AAACGCCAUUAUCACACUAAAU - 62
Evidence experimental
Illumina [4]
Database links
Predicted targets

References

  1. PubMed ID: 17604727
    A mammalian microRNA expression atlas based on small RNA library sequencing
    "Landgraf P, Rusu M, Sheridan R, Sewer A, Iovino N, Aravin A, Pfeffer S, Rice A, Kamphorst AO, Landthaler M, Lin C, Socci ND, Hermida L, Fulci V, Chiaretti S, Foa R, Schliwka J, Fuchs U, Novosel A, Muller RU, Schermer B, Bissels U, Inman J, Phan Q, Chien M"
    "Cell (2007) 129:1401-1414

  2. PubMed ID: 12007417
    Identification of tissue-specific microRNAs from mouse
    "Lagos-Quintana M, Rauhut R, Yalcin A, Meyer J, Lendeckel W, Tuschl T"
    "Curr Biol (2002) 12:735-739

  3. PubMed ID: 20215419
    MicroRNA transcriptome in the newborn mouse ovaries determined by massive parallel sequencing
    "Ahn HW, Morin RD, Zhao H, Harris RA, Coarfa C, Chen ZJ, Milosavljevic A, Marra MA, Rajkovic A"
    "Mol Hum Reprod (2010) 16:463-471

  4. PubMed ID: 20413612
    Mammalian microRNAs: experimental evaluation of novel and previously annotated genes
    "Chiang HR, Schoenfeld LW, Ruby JG, Auyeung VC, Spies N, Baek D, Johnston WK, Russ C, Luo S, Babiarz JE, Blelloch R, Schroth GP, Nusbaum C, Bartel DP"
    "Genes Dev (2010) 24:992-1009