Accession
MI0000271
Symbol
HGNC:
MIR181C
Description
Homo sapiens
hsa-mir-181c precursor miRNA
Gene family
MIPF0000007;
mir-181
Summary
Caution, this is an AI generated summary based on literature. This may have errors. ?
MIR181C is a microRNA that translocates to mitochondria and affects the expression of mitochondrial transcripts in CMCs [PMC7123062]. It has been found to target phosphatidylethanolamine binding protein 1 (PEPB1) and is downregulated in the TvN in both the membrane and cytoplasmic fraction [PMC10057657]. When MIR181C is hypermethylated, it leads to increased expression of NOTCH2/4 and KRAS, which affects proliferation levels [PMC7215608]. The transcription factor binding analysis suggests that rs8108402 may be the binding site for Sp1 transcription factors, indicating its role in the transcriptional regulation of MIR181C [PMC9396029]. Elevated levels of MIR181C may contribute to the reduction of CXCL8 [PMC5422244]. Quercetin treatment has been shown to suppress MIR181C expression in neutrophils [PMC5422244]. Dex treatment decreases MIR181C expression in T24 cells but not UMUC-3 cells [PMC5053652]. Hypermethylation of MIR181C has been observed in AD brains, leading to downregulation of its corresponding transcript [PMC4861808]. MIR181C is among several miRNAs predicted to target H-2Kb and H-2Db [PMC7655649]. It has also been identified as a potential marker for a positive response to chemoradiotherapy with TMZ in glioblastoma patients [PMC7073212]. Additionally, miRNA mimics have been used for overexpression studies of miR181a and MIR181C with different time points posttransfection or postirradiation observed [PMC8786676].
Literature search
279 open access papers mention hsa-mir-181c
(1258 sentences)
(1258 sentences)
Sequence
25356
reads,
322
reads per million, 130 experiments
cggaaaauuugccaaggguuugggggAACAUUCAACCUGUCGGUGAGUuugggcagcucaggcaAACCAUCGACCGUUGAGUGGACccugaggccuggaauugccauccu
.(((.......(((..(((((.((((..((((((((..(((((((.(((((...........)))))))))))).))))))))..)))).))))))))........))).
.(((.......(((..(((((.((((..((((((((..(((((((.(((((...........)))))))))))).))))))))..)))).))))))))........))).
Structure
c -aaauuug ag g AA CU A ggca gga cca gguuu gggg CAUUCAAC GUCGGUG GUuug g ||| ||| ||||| |||| |||||||| ||||||| ||||| c ccu ggu ccgga uccC GUGAGUUG CAGCUAC CAAac u u accguuaa -- g AG -C - ggac
Annotation confidence
High
Do you think this miRNA is real?
Comments
This human miRNA was predicted by computational methods using conservation with mouse and Fugu rubripes sequences [1]. Expression of the excised miR has been validated in zebrafish, and the ends mapped by cloning. Landgraf et al. confirm the expression of miR-181c in human [2].
Genome context
chr19: 13874699-13874808 [+]
Clustered miRNAs
1 other miRNA is < 10 kb from hsa-mir-181c
| Name | Accession | Chromosome | Start | End | Strand | Confidence |
|---|
Disease association
hsa-mir-181c is associated with one or more human diseases in the Human microRNA Disease Database
| Disease | Description | Category | PubMed ID |
|---|
Biological pathways
hsa-mir-181c is involved in one or more biological pathways:
(Source: Reactome)
(Source: Reactome)
Biological reactions
hsa-mir-181c is involved in one or more regulation/signalling events:
(Source: Reactome)
(Source: Reactome)
Database links
Mature hsa-miR-181c-5p
| Accession | MIMAT0000258 |
| Description | Homo sapiens hsa-miR-181c-5p mature miRNA |
| Sequence | 27 - AACAUUCAACCUGUCGGUGAGU - 48 |
| Evidence |
experimental
cloned [2] |
| Database links |
|
| Predicted targets |
|
Mature hsa-miR-181c-3p
| Accession | MIMAT0004559 |
| Description | Homo sapiens hsa-miR-181c-3p mature miRNA |
| Sequence | 65 - AACCAUCGACCGUUGAGUGGAC - 86 |
| Evidence |
experimental
cloned [2] |
| Database links |
|
| Predicted targets |
|
References
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