miRBase entry: hsa-mir-211

Stem-loop hsa-mir-211


Accession
MI0000287
Symbol
HGNC: MIR211
Description
Homo sapiens hsa-mir-211 precursor miRNA
Gene family
MIPF0000042; mir-204

Summary
Caution, this is an AI generated summary based on literature. This may have errors. ?

MIR211 is a cellular miRNA that has been found to be upregulated in various types of tumors, particularly in gliomas. Conversely, the downregulation of MIR211 can increase the sensitivity of glioma cells to temozolomide (TMZ) [PMC7732422]. In a study, it was observed that both MIR211 overexpression and EZRIN siRNA transfection led to an increase in the percentage of cells in the G0/G1 phase and a decrease in the percentage of cells in the S phase in human osteosarcoma cells [PMC6617937]. This suggests that MIR211 may play a role in cell cycle regulation. Additionally, MIR211 was selected as one of five cellular miRNAs for further investigation due to its potential complementary target sequence in the HIV-1 genome [PMC3256098]. The HIV-1 Nef gene is known to be dispensable for viral replication in cultured human cells [PMC3256098]. Overall, these findings highlight the potential significance of MIR211 as a regulator of cell cycle progression and its potential role in HIV-1 infection.

Literature search
96 open access papers mention hsa-mir-211
(799 sentences)

Sequence

47750 reads, 1763 reads per million, 51 experiments
ucaccuggccaugugacuugugggcUUCCCUUUGUCAUCCUUCGCCUagggcucugagcaggGCAGGGACAGCAAAGGGGUGCucaguugucacuucccacagcacggag
.....(((....(((((...(((((.(((((((((..(((((.((((...(((...))).)))))))))..))))))))).)))))...)))))...)))..........

Structure
-----ucacc   ccau     uug     U         CA     C    agg   c 
          ugg    gugac   ugggc UCCCUUUGU  UCCUU GCCU   gcu  
          |||    |||||   ||||| |||||||||  ||||| ||||   ||| u
          acc    cacug   acuCG GGGGAAACG  AGGGA CGgg   cga  
gaggcacgac   -cuu     uug     U         AC     -    --a   g 


Annotation confidence High
Do you think this miRNA is real?
Comments
This human miRNA was predicted by computational methods using conservation with mouse and Fugu rubripes sequences [1]. Expression of the excised miR has been validated in zebrafish, and the ends mapped by cloning. The sequence maps to human chromosome 15.

Genome context
chr15: 31065032-31065141 [-]

Disease association
hsa-mir-211 is associated with one or more human diseases in the Human microRNA Disease Database
Disease Description Category PubMed ID


Database links

Mature hsa-miR-211-5p

Accession MIMAT0000268
Description Homo sapiens hsa-miR-211-5p mature miRNA
Sequence 26 - UUCCCUUUGUCAUCCUUCGCCU - 47
Evidence not_experimental
Database links
Predicted targets

Mature hsa-miR-211-3p

Accession MIMAT0022694
Description Homo sapiens hsa-miR-211-3p mature miRNA
Sequence 63 - GCAGGGACAGCAAAGGGGUGC - 83
Evidence not_experimental
Database links
Predicted targets

References

  1. PubMed ID: 12624257
    Vertebrate microRNA genes
    "Lim LP, Glasner ME, Yekta S, Burge CB, Bartel DP"
    "Science (2003) 299:1540