Accession
MI0000290
Symbol
HGNC:
MIR214
Description
Homo sapiens
hsa-mir-214 precursor miRNA
Gene family
MIPF0000062;
mir-214
Summary
Caution, this is an AI generated summary based on literature. This may have errors. ?
MIR214 is a microRNA that has been reported to increase in the oxLDL-induced model, suggesting its potential role in endothelial injury [PMC9199460]. In addition to MIR214, miR-106 is another microRNA that has been found to increase in the same model [PMC9199460]. Inhibition of these molecules could potentially protect against endothelial injury [PMC9199460]. Furthermore, there are six gene-based genome-wide significant association signals at three novel genomic regions: 1q24.3 (DNM3OS, MIR214, and MIR3120), 9q22.32 (MIR23B and MIR27B), and 16p13.3 (LINC00921) [PMC5458088]. These regions are associated with various genetic factors that may play a role in different biological processes or diseases [PMC5458088]. Overall, understanding the functions and regulation of microRNAs like MIR214 can provide insights into their potential therapeutic applications in protecting against endothelial injury or other related conditions.
Literature search
289 open access papers mention hsa-mir-214
(2846 sentences)
(2846 sentences)
Sequence
58209
reads,
943
reads per million, 111 experiments
ggccuggcuggacagaguugucaugugucUGCCUGUCUACACUUGCUGUGCagaacauccgcucaccuguACAGCAGGCACAGACAGGCAGUcacaugacaacccagccu
.....((((((.....(((((((((((.((((((((((...((((((((((((.............))))))))))))...)))))))))).))))))))))))))))).
.....((((((.....(((((((((((.((((((((((...((((((((((((.............))))))))))))...)))))))))).))))))))))))))))).
Structure
ggccu acaga u ACA aacau
ggcugg guugucaugug cUGCCUGUCU CUUGCUGUGCag c
|||||| ||||||||||| |||||||||| |||||||||||| c
ccgacc caacaguacac GACGGACAGA GGACGACAuguc g
----u ----- U CAC cacuc
Annotation confidence
High
Do you think this miRNA is real?
Comments
This human miRNA was predicted by computational methods using conservation with mouse and Fugu rubripes sequences [1]. Expression of the excised miR has been validated in zebrafish, and the ends mapped by cloning. Landgraf et al. confirm expression in human [2]. The mature sequence shown here represents the most commonly cloned form from large-scale cloning studies [2].
Genome context
chr1: 172138798-172138907 [-]
Clustered miRNAs
2 other miRNAs are < 10 kb from hsa-mir-214
| Name | Accession | Chromosome | Start | End | Strand | Confidence |
|---|
Disease association
hsa-mir-214 is associated with one or more human diseases in the Human microRNA Disease Database
| Disease | Description | Category | PubMed ID |
|---|
Biological pathways
hsa-mir-214 is involved in one or more biological pathways:
(Source: Reactome)
(Source: Reactome)
Biological reactions
hsa-mir-214 is involved in one or more regulation/signalling events:
(Source: Reactome)
(Source: Reactome)
Database links
Mature hsa-miR-214-5p
| Accession | MIMAT0004564 |
| Description | Homo sapiens hsa-miR-214-5p mature miRNA |
| Sequence | 30 - UGCCUGUCUACACUUGCUGUGC - 51 |
| Evidence |
experimental
cloned [2-3], Northern [3] |
| Database links |
|
| Predicted targets |
|
Mature hsa-miR-214-3p
| Accession | MIMAT0000271 |
| Description | Homo sapiens hsa-miR-214-3p mature miRNA |
| Sequence | 71 - ACAGCAGGCACAGACAGGCAGU - 92 |
| Evidence |
experimental
cloned [2] |
| Database links |
|
| Predicted targets |
|
References
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