Stem-loop mmu-mir-106a

Accession

MI0000406

Symbol

MGI: Mir106a

Description

Mus musculus mmu-mir-106a precursor miRNA mir-17

Gene
family

RF00051; mir-17

Literature search

99 open access papers mention mmu-mir-106a
(395 sentences)

Sequence

8909 reads, 61 reads per million, 82 experiments

auguCAAAGUGCUAACAGUGCAGGUAGcuuuuugaguucuACUGCAGUGCCAGCACUUCUUACau
((((..(((((((..((.(((((..(((((...)))))...))))).))..)))))))...))))

Structure

    -CA       AA  G     -GU     u 
augu   AAGUGCU  CA UGCAG   AGcuu  
||||   |||||||  || |||||   ||||| u
uaCA   UUCACGA  GU ACGUC   uugag  
    UUC       CC  G     Auc     u 

Annotation confidence Medium

Comments

Mouse and human miR-106a (MIR:MI0000406 and MIR:MI0000113) differ at two positions but the precursor sequences are clearly closely related. The sequences are also related to mir-17 (MIR:MI0000071 and MIR:MI0000687). The mature sequence shown here represents the most commonly cloned form from large-scale cloning studies [2].

Genome context

chrX: 52742503-52742567 [-]

Clustered miRNAs

5 other miRNAs are < 10 kb from mmu-mir-106a

Mature mmu-miR-106a-5p

• Accession: MIMAT0000385
• Description: Mus musculus mmu-miR-106a-5p mature miRNA
• Sequence: 5 - CAAAGUGCUAACAGUGCAGGUAG - 27
• Evidence: experimental ; cloned [1-2], Illumina [3-4]

Mature mmu-miR-106a-3p

• Accession: MIMAT0017009
• Description: Mus musculus mmu-miR-106a-3p mature miRNA
• Sequence: 41 - ACUGCAGUGCCAGCACUUCUUAC - 63
• Evidence: experimental ; Illumina [4]

References

1. PubMed ID: 17604727
   A mammalian microRNA expression atlas based on small RNA library sequencing
   "Landgraf P, Rusu M, Sheridan R, Sewer A, Iovino N, Aravin A, Pfeffer S, Rice A, Kamphorst AO, Landthaler M, Lin C, Socci ND, Hermida L, Fulci V, Chiaretti S, Foa R, Schliwka J, Fuchs U, Novosel A, Muller RU, Schermer B, Bissels U, Inman J, Phan Q, Chien M"
   "Cell (2007) 129:1401-1414


2. PubMed ID: 12919684
   Embryonic stem cell-specific MicroRNAs
   "Houbaviy HB, Murray MF, Sharp PA"
   "Dev Cell (2003) 5:351-358


3. PubMed ID: 20215419
   MicroRNA transcriptome in the newborn mouse ovaries determined by massive parallel sequencing
   "Ahn HW, Morin RD, Zhao H, Harris RA, Coarfa C, Chen ZJ, Milosavljevic A, Marra MA, Rajkovic A"
   "Mol Hum Reprod (2010) 16:463-471


4. PubMed ID: 20413612
   Mammalian microRNAs: experimental evaluation of novel and previously annotated genes
   "Chiang HR, Schoenfeld LW, Ruby JG, Auyeung VC, Spies N, Baek D, Johnston WK, Russ C, Luo S, Babiarz JE, Blelloch R, Schroth GP, Nusbaum C, Bartel DP"
   "Genes Dev (2010) 24:992-1009