miRBase entry: mmu-mir-200c

Stem-loop mmu-mir-200c


Accession
MI0000694
Symbol
MGI: Mir200c
Description
Mus musculus mmu-mir-200c precursor miRNA
Gene family
MIPF0000019; mir-8

Literature search
303 open access papers mention mmu-mir-200c
(2882 sentences)

Sequence

101927 reads, 615 reads per million, 102 experiments
cccuCGUCUUACCCAGCAGUGUUUGGgugcugguugggagucucUAAUACUGCCGGGUAAUGAUGGAgg
.(((((((((((((.((((((((.(((.(((.......)))))).)))))))).)))))).))).))))

Structure
c    -   -      A        U   u   gg 
 ccuC GUC UUACCC GCAGUGUU GGg gcu  u
 |||| ||| |||||| |||||||| ||| |||  u
 ggAG UAG AAUGGG CGUCAUAA cuc uga  g
-    G   U      C        U   -   gg 


Annotation confidence High
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Comments
Mouse mir-200c is predicted [3] based on homology to a cloned miR from human (MIR:MI0000650) [1]. Its expression in mouse was later verified independently [2,4]. The mature sequence shown here represents the most commonly cloned form from large-scale cloning studies [4].

Genome context
chr6: 124718322-124718390 [-]
Clustered miRNAs
1 other miRNA is < 10 kb from mmu-mir-200c
Name Accession Chromosome Start End Strand Confidence




Database links

Mature mmu-miR-200c-5p

Accession MIMAT0004663
Description Mus musculus mmu-miR-200c-5p mature miRNA
Sequence 5 - CGUCUUACCCAGCAGUGUUUGG - 26
Evidence experimental
cloned [4], Illumina [5-6]
Database links
Predicted targets

Mature mmu-miR-200c-3p

Accession MIMAT0000657
Description Mus musculus mmu-miR-200c-3p mature miRNA
Sequence 45 - UAAUACUGCCGGGUAAUGAUGGA - 67
Evidence experimental
cloned [2,4], Illumina [5-6]
Database links
Predicted targets

References

  1. PubMed ID: 14573789
    Reduced accumulation of specific microRNAs in colorectal neoplasia
    "Michael MZ, O' Connor SM, van Holst Pellekaan NG, Young GP, James RJ"
    "Mol Cancer Res (2003) 1:882-891

  2. PubMed ID: 17604727
    A mammalian microRNA expression atlas based on small RNA library sequencing
    "Landgraf P, Rusu M, Sheridan R, Sewer A, Iovino N, Aravin A, Pfeffer S, Rice A, Kamphorst AO, Landthaler M, Lin C, Socci ND, Hermida L, Fulci V, Chiaretti S, Foa R, Schliwka J, Fuchs U, Novosel A, Muller RU, Schermer B, Bissels U, Inman J, Phan Q, Chien M"
    "Cell (2007) 129:1401-1414

  3. PubMed ID: 15538371
    A pancreatic islet-specific microRNA regulates insulin secretion
    "Poy MN, Eliasson L, Krutzfeldt J, Kuwajima S, Ma X, Macdonald PE, Pfeffer S, Tuschl T, Rajewsky N, Rorsman P, Stoffel M"
    "Nature (2004) 432:226-230

  4. PubMed ID: 20215419
    MicroRNA transcriptome in the newborn mouse ovaries determined by massive parallel sequencing
    "Ahn HW, Morin RD, Zhao H, Harris RA, Coarfa C, Chen ZJ, Milosavljevic A, Marra MA, Rajkovic A"
    "Mol Hum Reprod (2010) 16:463-471

  5. PubMed ID: 20413612
    Mammalian microRNAs: experimental evaluation of novel and previously annotated genes
    "Chiang HR, Schoenfeld LW, Ruby JG, Auyeung VC, Spies N, Baek D, Johnston WK, Russ C, Luo S, Babiarz JE, Blelloch R, Schroth GP, Nusbaum C, Bartel DP"
    "Genes Dev (2010) 24:992-1009

  6. PubMed ID: 15634332
    New human and mouse microRNA genes found by homology search
    "Weber MJ"
    "FEBS J (2005) 272:59-73