Stem-loop hsa-mir-128-2

Accession

MI0000727

Symbol

HGNC: MIR128-2

Description

Homo sapiens hsa-mir-128-2 precursor miRNA mir-128

Gene
family

RF00649; mir-128

Literature search

174 open access papers mention hsa-mir-128-2
(979 sentences)

Sequence

175902 reads, 732 reads per million, 134 experiments

ugugcagugggaagGGGGGCCGAUACACUGUACGAGAgugaguagcaggucUCACAGUGAACCGGUCUCUUUcccuacuguguc
...((((((((.((((((((((...((((((..((((.(........).))))))))))...)))))))))).))))))))...

Structure

ugu        a          AUA      AC    g gag 
   gcaguggg agGGGGGCCG   CACUGU  GAGA u   u
   |||||||| ||||||||||   ||||||  |||| |    
   ugucaucc UUUCUCUGGC   GUGACA  CUcu g   a
cug        c          CAA      --    g acg 

Annotation confidence High

Comments

The most commonly cloned mature sequences derived from the previously annotated mir-128a and mir-128b were shown by Landgraf et al to be identical [3]. The sequences are therefore renamed mir-128-1 and mir-128-2.

Genome context

chr3: 35744476-35744559 [+]

Disease association

hsa-mir-128-2 is associated with one or more human diseases in the Human microRNA Disease Database

Mature hsa-miR-128-3p

• Accession: MIMAT0000424
• Description: Homo sapiens hsa-miR-128-3p mature miRNA
• Sequence: 52 - UCACAGUGAACCGGUCUCUUU - 72
• Evidence: experimental ; cloned [3], Illumina [4]

Mature hsa-miR-128-2-5p

• Accession: MIMAT0031095
• Description: Homo sapiens hsa-miR-128-2-5p mature miRNA
• Sequence: 15 - GGGGGCCGAUACACUGUACGAGA - 37
• Evidence: experimental ; Illumina [4]

References

1. PubMed ID: 17604727
   A mammalian microRNA expression atlas based on small RNA library sequencing
   "Landgraf P, Rusu M, Sheridan R, Sewer A, Iovino N, Aravin A, Pfeffer S, Rice A, Kamphorst AO, Landthaler M, Lin C, Socci ND, Hermida L, Fulci V, Chiaretti S, Foa R, Schliwka J, Fuchs U, Novosel A, Muller RU, Schermer B, Bissels U, Inman J, Phan Q, Chien M"
   "Cell (2007) 129:1401-1414


2. PubMed ID: 12624257
   Vertebrate microRNA genes
   "Lim LP, Glasner ME, Yekta S, Burge CB, Bartel DP"
   "Science (2003) 299:1540


3. PubMed ID: 12007417
   Identification of tissue-specific microRNAs from mouse
   "Lagos-Quintana M, Rauhut R, Yalcin A, Meyer J, Lendeckel W, Tuschl T"
   "Curr Biol (2002) 12:735-739


4. PubMed ID: 23034410
   Birth and expression evolution of mammalian microRNA genes
   "Meunier J, Lemoine F, Soumillon M, Liechti A, Weier M, Guschanski K, Hu H, Khaitovich P, Kaessmann H"
   "Genome Res (2013) 23:34-45