Accession
MI0000746
Symbol
HGNC:
MIR99B
Description
Homo sapiens
hsa-mir-99b precursor miRNA
Summary
Caution, this is an AI generated summary based on literature. This may have errors. ?
MIR99B is a microRNA located just downstream of a cluster of microRNAs on the human transcriptional unit AY358799 and is highly expressed in various biological contexts [PMC3783845], [PMC7912193]. It plays a role in the immune response by restricting bacterial growth when its expression is blocked [PMC3576108]. Despite its high expression levels, MIR99B, along with other frequently expressed miRNAs, targets fewer genes compared to less expressed miRNAs [PMC7912193]. It has been identified in extracellular vesicles (EVs) and is the second most expressed miRNA within them, suggesting its potential role in intercellular communication [PMC7912193]. MIR99B has been implicated in the regulation of insulin-like growth factor 1 receptor (IGF1R) and may contribute to a coordinated shutdown of signal transduction pathways that block NF-κB pathways [PMC4290566]. In various diseases, MIR99B expression levels differ; it is upregulated in cystic fibrosis airway epithelial cells and downregulated in endometrial cancer cells, indicating its complex role as both a potential tumor suppressor and as part of the body's response to certain diseases [PMC7493015], [PMC6994408]. Furthermore, MIR99B has been engineered into an adenovirus to enhance antitumoral activity against pancreatic cancer cells, highlighting its therapeutic potential [PMC9171400].
Literature search
137 open access papers mention hsa-mir-99b
(407 sentences)
(407 sentences)
Sequence
662095
reads,
1445
reads per million, 130 experiments
ggcaccCACCCGUAGAACCGACCUUGCGgggccuucgccgcacaCAAGCUCGUGUCUGUGGGUCCGuguc
(((((..(((((((((..(((.((((.(.(((....))).)...)))).)))..)))))))))..)))))
(((((..(((((((((..(((.((((.(.(((....))).)...)))).)))..)))))))))..)))))
Structure
cC AC C --C g c
ggcac ACCCGUAGA CGA CUUG G ggc u
||||| ||||||||| ||| |||| | |||
cuguG UGGGUGUCU GCU GAAC c ccg u
CC GU C aca g c
Annotation confidence
High
Do you think this miRNA is real?
Comments
This sequence is the predicted human homologue of mouse miR-99b, cloned from mouse brain [1] and embryonic stem cells [2,3]. Its expression was later validated in human [4-6].
Genome context
chr19: 51692612-51692681 [+]
Clustered miRNAs
2 other miRNAs are < 10 kb from hsa-mir-99b
| Name | Accession | Chromosome | Start | End | Strand | Confidence |
|---|
Disease association
hsa-mir-99b is associated with one or more human diseases in the Human microRNA Disease Database
| Disease | Description | Category | PubMed ID |
|---|
Database links
Mature hsa-miR-99b-5p
| Accession | MIMAT0000689 |
| Description | Homo sapiens hsa-miR-99b-5p mature miRNA |
| Sequence | 7 - CACCCGUAGAACCGACCUUGCG - 28 |
| Evidence |
experimental
cloned [4-6] |
| Database links |
|
| Predicted targets |
|
Mature hsa-miR-99b-3p
| Accession | MIMAT0004678 |
| Description | Homo sapiens hsa-miR-99b-3p mature miRNA |
| Sequence | 45 - CAAGCUCGUGUCUGUGGGUCCG - 66 |
| Evidence |
experimental
cloned [5] |
| Database links |
|
| Predicted targets |
|
References
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