Stem-loop hsa-mir-363

Accession

MI0000764

Symbol

HGNC: MIR363

Description

Homo sapiens hsa-mir-363 precursor miRNA

Gene family

MIPF0000138; mir-363

Summary

Caution, this is an AI generated summary based on literature. This may have errors.

MIR363, a type of microRNA, has been investigated in the context of prostate cancer (PCa) [PMC10067432]. Research utilizing RIP assays has demonstrated that MIR363, along with miR708 and circEZH2E2/E3, can be identified in immunoprecipitates obtained with anti-Ago2 [PMC10067432]. Additionally, the levels of MIR363 and miR708 were found to be significantly lower in PCa tissue samples and PCa cells (PC3 and DU145) compared to benign prostatic hyperplasia (BPH) [PMC10067432]. These findings suggest a potential involvement of MIR363 in the development or progression of PCa [PMC10067432].

Literature search

76 open access papers mention hsa-mir-363
(499 sentences)

Sequence

91825 reads, 532 reads per million, 128 experiments

uguuguCGGGUGGAUCACGAUGCAAUUUugaugaguaucauaggagaaaAAUUGCACGGUAUCCAUCUGUAaacc
.(((..(((((((((..((.(((((((((..................)))))))))))..)))))))))..))).

Structure

u   gu         CA  A         gaugagua 
 guu  CGGGUGGAU  CG UGCAAUUUu        u
 |||  |||||||||  || |||||||||         
 caa  GUCUACCUA  GC ACGUUAAaa        c
c   AU         UG  -         agaggaua 

Annotation confidence High

Genome context

chrX: 134169378-134169452 [-]

Clustered miRNAs

5 other miRNAs are < 10 kb from hsa-mir-363

Disease association

hsa-mir-363 is associated with one or more human diseases in the Human microRNA Disease Database

Mature hsa-miR-363-5p

• Accession: MIMAT0003385
• Description: Homo sapiens hsa-miR-363-5p mature miRNA
• Sequence: 7 - CGGGUGGAUCACGAUGCAAUUU - 28
• Evidence: experimental ; cloned [2-3]

Mature hsa-miR-363-3p

• Accession: MIMAT0000707
• Description: Homo sapiens hsa-miR-363-3p mature miRNA
• Sequence: 50 - AAUUGCACGGUAUCCAUCUGUA - 71
• Evidence: experimental ; array-cloned [1], cloned [2-3]

References

1. PubMed ID: 17604727
   A mammalian microRNA expression atlas based on small RNA library sequencing
   "Landgraf P, Rusu M, Sheridan R, Sewer A, Iovino N, Aravin A, Pfeffer S, Rice A, Kamphorst AO, Landthaler M, Lin C, Socci ND, Hermida L, Fulci V, Chiaretti S, Foa R, Schliwka J, Fuchs U, Novosel A, Muller RU, Schermer B, Bissels U, Inman J, Phan Q, Chien M"
   "Cell (2007) 129:1401-1414


2. PubMed ID: 15965474
   Identification of hundreds of conserved and nonconserved human microRNAs
   "Bentwich I, Avniel A, Karov Y, Aharonov R, Gilad S, Barad O, Barzilai A, Einat P, Einav U, Meiri E, Sharon E, Spector Y, Bentwich Z"
   "Nat Genet (2005) 37:766-770


3. PubMed ID: 16274478
   Identification of clustered microRNAs using an ab initio prediction method
   Sewer A, Paul N, Landgraf P, Aravin A, Pfeffer S, Brownstein MJ, Tuschl T, van Nimwegen E, Zavolan M
   BMC Bioinformatics (2005) 6:267