miRBase entry: hsa-mir-376a-1

Stem-loop hsa-mir-376a-1


Accession
MI0000784
Symbol
HGNC: MIR376A1
Description
Homo sapiens hsa-mir-376a-1 precursor miRNA
Gene family
MIPF0000091; mir-368

Literature search
80 open access papers mention hsa-mir-376a-1
(414 sentences)

Sequence

2872 reads, 91 reads per million, 69 experiments
uaaaagGUAGAUUCUCCUUCUAUGAGUAcauuauuuaugauuaAUCAUAGAGGAAAAUCCACGUuuuc
.((((.((.((((.((((.((((((...(((.....))).....)))))))))).)))).)).)))).

Structure
u    g  A    C    U      --GUA   u 
 aaaa GU GAUU UCCU CUAUGA     cau a
 |||| || |||| |||| ||||||     ||| u
 uuuU CA CUAA AGGA GAUACU     gua u
c    G  C    A    -      Aauua   u 


Annotation confidence High
Do you think this miRNA is real?
Comments
The mature miR-376a products have been shown to be modified by A to I edits [3].

Genome context
chr14: 101040782-101040849 [+]
Clustered miRNAs
15 other miRNAs are < 10 kb from hsa-mir-376a-1
Name Accession Chromosome Start End Strand Confidence




Disease association
hsa-mir-376a-1 is associated with one or more human diseases in the Human microRNA Disease Database
Disease Description Category PubMed ID


Database links

Mature hsa-miR-376a-5p

Accession MIMAT0003386
Description Homo sapiens hsa-miR-376a-5p mature miRNA
Sequence 7 - GUAGAUUCUCCUUCUAUGAGUA - 28
Evidence experimental
cloned [2,4]
Database links
Predicted targets

Mature hsa-miR-376a-3p

Accession MIMAT0000729
Description Homo sapiens hsa-miR-376a-3p mature miRNA
Sequence 44 - AUCAUAGAGGAAAAUCCACGU - 64
Evidence experimental
cloned [1,3], SOLiD [4]
Database links
Predicted targets

References

  1. PubMed ID: 17604727
    A mammalian microRNA expression atlas based on small RNA library sequencing
    "Landgraf P, Rusu M, Sheridan R, Sewer A, Iovino N, Aravin A, Pfeffer S, Rice A, Kamphorst AO, Landthaler M, Lin C, Socci ND, Hermida L, Fulci V, Chiaretti S, Foa R, Schliwka J, Fuchs U, Novosel A, Muller RU, Schermer B, Bissels U, Inman J, Phan Q, Chien M"
    "Cell (2007) 129:1401-1414

  2. PubMed ID: 15891114
    Clustering and conservation patterns of human microRNAs
    "Altuvia Y, Landgraf P, Lithwick G, Elefant N, Pfeffer S, Aravin A, Brownstein MJ, Tuschl T, Margalit H"
    "Nucleic Acids Res (2005) 33:2697-2706

  3. PubMed ID: 16274478
    Identification of clustered microRNAs using an ab initio prediction method
    Sewer A, Paul N, Landgraf P, Aravin A, Pfeffer S, Brownstein MJ, Tuschl T, van Nimwegen E, Zavolan M
    BMC Bioinformatics (2005) 6:267

  4. PubMed ID: 17322061
    Redirection of silencing targets by adenosine-to-inosine editing of miRNAs
    "Kawahara Y, Zinshteyn B, Sethupathy P, Iizasa H, Hatzigeorgiou AG, Nishikura K"
    "Science (2007) 315:1137-1140