Accession
MI0000786
Symbol
HGNC:
MIR378A
Description
Homo sapiens
hsa-mir-378a precursor miRNA
Gene family
MIPF0000168;
mir-378
Summary
Caution, this is an AI generated summary based on literature. This may have errors. ?
MIR378A is a small RNA molecule that has been found to be positively correlated with age, along with miR-34a and miR-320b, and negatively associated with age, along with miR-20a, miR-30b, miR-106b, miR-191, miR-301a, and miR-374a [PMC6196565]. The UCCU sequence of RNA has been chosen for analysis due to its presence in small RNAs such as miR23a, MIR378A, and miR344 [PMC6004406]. MIR378A has been found to be downregulated in the sperm of fathers with high paternal depressive symptoms compared to fathers without such symptoms [PMC8157381]. Additionally, MIR378A has been detected in extracellular vesicles (EVs) during the differentiation of human embryonic stem cells into cardiac cells [PMC7912193]. EVs have been shown to contain several other microRNAs (miRNAs) along with MIR378A [PMC7912193]. The levels of primary MIR378A have been determined using quantitative real-time polymerase chain reaction (qRT-PCR) along with 18 s rRNA [PMC8393456]. References: [PMC6196565] - https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6196565/ [PMC6004406] - https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6004406/ [PMC8157381] - https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8157381/ [PMC7912193] - https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7912193/ [PMC8393456] - https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8393456/
Literature search
212 open access papers mention hsa-mir-378a
(1262 sentences)
(1262 sentences)
Sequence
5214209
reads,
6859
reads per million, 154 experiments
agggCUCCUGACUCCAGGUCCUGUGUguuaccuagaaauagcACUGGACUUGGAGUCAGAAGGCcu
(((.((.((((((((((((((.((((..(........)..)))).)))))))))))))).)).)))
(((.((.((((((((((((((.((((..(........)..)))).)))))))))))))).)).)))
Structure
g C U gu acc agg CU CUGACUCCAGGUCC GUGU u u ||| || |||||||||||||| |||| | ucC GA GACUGAGGUUCAGG CAcg a a G A U au aag
Annotation confidence
High
Do you think this miRNA is real?
Comments
miR-422b was the most abundant miRNA cloned from human promyelocytic leukemia (HL-60) cells [2]. The sequence originates from the opposite arm of the human homologue of previously identified mouse mir-378 [1]. Landgraf et al. show that the 3' product (previously called miR-422b) is the predominant one [3]. Further, mir-378 and mir-422a loci are unrelated. miR-422b is thus renamed miR-378 here.
Genome context
chr5: 149732825-149732890 [+]
Disease association
hsa-mir-378a is associated with one or more human diseases in the Human microRNA Disease Database
| Disease | Description | Category | PubMed ID |
|---|
Biological pathways
hsa-mir-378a is involved in one or more biological pathways:
(Source: Reactome)
(Source: Reactome)
Biological reactions
hsa-mir-378a is involved in one or more regulation/signalling events:
(Source: Reactome)
(Source: Reactome)
Database links
Mature hsa-miR-378a-5p
| Accession | MIMAT0000731 |
| Description | Homo sapiens hsa-miR-378a-5p mature miRNA |
| Sequence | 5 - CUCCUGACUCCAGGUCCUGUGU - 26 |
| Evidence |
experimental
cloned [3] |
| Database links |
|
| Predicted targets |
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Mature hsa-miR-378a-3p
| Accession | MIMAT0000732 |
| Description | Homo sapiens hsa-miR-378a-3p mature miRNA |
| Sequence | 43 - ACUGGACUUGGAGUCAGAAGGC - 64 |
| Evidence |
experimental
cloned [2-3], Northern [2] |
| Database links |
|
| Predicted targets |
|
References
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