miRBase entry: hsa-mir-381

Stem-loop hsa-mir-381


Accession
MI0000789
Symbol
HGNC: MIR381
Description
Homo sapiens hsa-mir-381 precursor miRNA
Gene family
MIPF0000018; mir-154

Literature search
72 open access papers mention hsa-mir-381
(408 sentences)

Sequence

11272 reads, 109 reads per million, 108 experiments
uacuuaaAGCGAGGUUGCCCUUUGUAUAUucgguuuauugacauggaaUAUACAAGGGCAAGCUCUCUGUgagua
((((((.((.(((.((((((((.((((((((.((........)).)))))))))))))))).))).)).))))))

Structure
      a  C   G        U        g  uua 
uacuua AG GAG UUGCCCUU GUAUAUuc gu   u
|||||| || ||| |||||||| |||||||| ||    
augagU UC CUC AACGGGAA CAUAUaag ua   u
      G  U   G        -        g  cag 


Annotation confidence High
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Genome context
chr14: 101045920-101045994 [+]
Clustered miRNAs
18 other miRNAs are < 10 kb from hsa-mir-381
Name Accession Chromosome Start End Strand Confidence




Disease association
hsa-mir-381 is associated with one or more human diseases in the Human microRNA Disease Database
Disease Description Category PubMed ID


Database links

Mature hsa-miR-381-3p

Accession MIMAT0000736
Description Homo sapiens hsa-miR-381-3p mature miRNA
Sequence 49 - UAUACAAGGGCAAGCUCUCUGU - 70
Evidence experimental
cloned [1-2], SOLiD [3]
Database links
Predicted targets

Mature hsa-miR-381-5p

Accession MIMAT0022862
Description Homo sapiens hsa-miR-381-5p mature miRNA
Sequence 8 - AGCGAGGUUGCCCUUUGUAUAU - 29
Evidence experimental
SOLiD [3]
Database links
Predicted targets

References

  1. PubMed ID: 17604727
    A mammalian microRNA expression atlas based on small RNA library sequencing
    "Landgraf P, Rusu M, Sheridan R, Sewer A, Iovino N, Aravin A, Pfeffer S, Rice A, Kamphorst AO, Landthaler M, Lin C, Socci ND, Hermida L, Fulci V, Chiaretti S, Foa R, Schliwka J, Fuchs U, Novosel A, Muller RU, Schermer B, Bissels U, Inman J, Phan Q, Chien M"
    "Cell (2007) 129:1401-1414

  2. PubMed ID: 16274478
    Identification of clustered microRNAs using an ab initio prediction method
    Sewer A, Paul N, Landgraf P, Aravin A, Pfeffer S, Brownstein MJ, Tuschl T, van Nimwegen E, Zavolan M
    BMC Bioinformatics (2005) 6:267

  3. PubMed ID: 22282338
    Deep-sequencing of endothelial cells exposed to hypoxia reveals the complexity of known and novel microRNAs
    "Voellenkle C, Rooij Jv, Guffanti A, Brini E, Fasanaro P, Isaia E, Croft L, David M, Capogrossi MC, Moles A, Felsani A, Martelli F"
    "RNA (2012) 18:472-484