Stem-loop hsa-mir-331

Accession

MI0000812

Symbol

HGNC: MIR331

Description

Homo sapiens hsa-mir-331 precursor miRNA mir-331

Gene
family

RF00769; mir-331

Literature search

78 open access papers mention hsa-mir-331
(231 sentences)

Sequence

104961 reads, 309 reads per million, 126 experiments

gaguuugguuuuguuuggguuuguuCUAGGUAUGGUCCCAGGGAUCCcagaucaaaccagGCCCCUGGGCCUAUCCUAGAAccaaccuaagcuc
............(((((((((.((((((((.((((.(((((((...((...........)).))))))).)))))))))))).)))))))))..

Structure

gaguuugguuuu         u        U    U       AUC  agau 
            guuuggguu guuCUAGG AUGG CCCAGGG   Cc    c
            ||||||||| |||||||| |||| |||||||   ||    a
            cgaauccaa cAAGAUCC UAUC GGGUCCC   Gg    a
----------cu         c        -    C       --C  acca 

Annotation confidence Not enough data

Comments

This sequence is the predicted homologue of a miRNA cloned from rat neuronal tissue [1,2], later verified in human [3].

Genome context

chr12: 95308420-95308513 [+]

Clustered miRNAs

1 other miRNA is < 10 kb from hsa-mir-331

Mature hsa-miR-331-5p

• Accession: MIMAT0004700
• Description: Homo sapiens hsa-miR-331-5p mature miRNA
• Sequence: 26 - CUAGGUAUGGUCCCAGGGAUCC - 47
• Evidence: experimental ; cloned [3]

Mature hsa-miR-331-3p

• Accession: MIMAT0000760
• Description: Homo sapiens hsa-miR-331-3p mature miRNA
• Sequence: 61 - GCCCCUGGGCCUAUCCUAGAA - 81
• Evidence: experimental ; cloned [3-4]

References

1. PubMed ID: 17604727
   A mammalian microRNA expression atlas based on small RNA library sequencing
   "Landgraf P, Rusu M, Sheridan R, Sewer A, Iovino N, Aravin A, Pfeffer S, Rice A, Kamphorst AO, Landthaler M, Lin C, Socci ND, Hermida L, Fulci V, Chiaretti S, Foa R, Schliwka J, Fuchs U, Novosel A, Muller RU, Schermer B, Bissels U, Inman J, Phan Q, Chien M"
   "Cell (2007) 129:1401-1414


2. PubMed ID: 17616659
   Patterns of known and novel small RNAs in human cervical cancer
   "Lui WO, Pourmand N, Patterson BK, Fire A"
   "Cancer Res (2007) 67:6031-6043


3. PubMed ID: 15634332
   New human and mouse microRNA genes found by homology search
   "Weber MJ"
   "FEBS J (2005) 272:59-73


4. PubMed ID: 14691248
   Identification of many microRNAs that copurify with polyribosomes in mammalian neurons
   "Kim J, Krichevsky A, Grad Y, Hayes GD, Kosik KS, Church GM, Ruvkun G"
   "Proc Natl Acad Sci U S A (2004) 101:360-365