Stem-loop rno-mir-22

Accession

MI0000851

Description

Rattus norvegicus rno-mir-22 precursor miRNA

Literature search

41 open access papers mention rno-mir-22
(290 sentences)

Sequence

102501016 reads, 82773 reads per million, 510 experiments

accuggcugagccgcaguAGUUCUUCAGUGGCAAGCUUUAuguccugacccagcuaAAGCUGCCAGUUGAAGAACUGUugcccucugccacuggc
.((((((.(((..((((((((((((((((((((.((((((.((.........))))))))))))).))))))))))))))).))).))))..)).

Structure

a  --    u   cc               -     A      u  ccu 
 cc  uggc gag  gcaguAGUUCUUCAG UGGCA GCUUUA gu   g
 ||  |||| |||  ||||||||||||||| ||||| |||||| ||   a
 gg  accg cuc  cguUGUCAAGAAGUU ACCGU CGAAau cg   c
c  uc    u   -c               G     -      -  acc 

Annotation confidence Medium

Comments

The mature sequence shown here represents the most commonly cloned form from large-scale cloning studies [3]. The ends of the miRNA may be offset with respect to previous annotations.

Genome context

chr10: 62299592-62299686 [+]

Clustered miRNAs

1 other miRNA is < 10 kb from rno-mir-22

Mature rno-miR-22-5p

• Accession: MIMAT0003152
• Description: Rattus norvegicus rno-miR-22-5p mature miRNA
• Sequence: 19 - AGUUCUUCAGUGGCAAGCUUUA - 40
• Evidence: experimental ; cloned [2-3], SOLiD [5]

Mature rno-miR-22-3p

• Accession: MIMAT0000791
• Description: Rattus norvegicus rno-miR-22-3p mature miRNA
• Sequence: 57 - AAGCUGCCAGUUGAAGAACUGU - 78
• Evidence: experimental ; cloned [1-4], SOLiD [5]

References

1. PubMed ID: 17604727
   A mammalian microRNA expression atlas based on small RNA library sequencing
   "Landgraf P, Rusu M, Sheridan R, Sewer A, Iovino N, Aravin A, Pfeffer S, Rice A, Kamphorst AO, Landthaler M, Lin C, Socci ND, Hermida L, Fulci V, Chiaretti S, Foa R, Schliwka J, Fuchs U, Novosel A, Muller RU, Schermer B, Bissels U, Inman J, Phan Q, Chien M"
   "Cell (2007) 129:1401-1414


2. PubMed ID: 16766679
   Identification and characterization of two novel classes of small RNAs in the mouse germline: retrotransposon-derived siRNAs in oocytes and germline small RNAs in testes
   "Watanabe T, Takeda A, Tsukiyama T, Mise K, Okuno T, Sasaki H, Minami N, Imai H"
   "Genes Dev (2006) 20:1732-1743


3. PubMed ID: 14691248
   Identification of many microRNAs that copurify with polyribosomes in mammalian neurons
   "Kim J, Krichevsky A, Grad Y, Hayes GD, Kosik KS, Church GM, Ruvkun G"
   "Proc Natl Acad Sci U S A (2004) 101:360-365


4. PubMed ID: 20403161
   Small RNA expression and strain specificity in the rat
   Linsen SE, de Wit E, de Bruijn E, Cuppen E
   BMC Genomics (2010) 11:249


5. PubMed ID: 17805466
   Cloning and identification of novel microRNAs from rat hippocampus
   "He X, Zhang Q, Liu Y, Pan X"
   "Acta Biochim Biophys Sin (Shanghai) (2007) 39:708-714