Stem-loop rno-mir-125a

Accession

MI0000895

Description

Rattus norvegicus rno-mir-125a precursor miRNA

Gene family

MIPF0000033; mir-10

Literature search

44 open access papers mention rno-mir-125a
(224 sentences)

Sequence

5290061 reads, 4841 reads per million, 502 experiments

ugccggccucugggUCCCUGAGACCCUUUAACCUGUGAggacguccagggucACAGGUGAGGUUCUUGGGAGCCuggcgccuggc
.(((((.(.((((((.(((((((.((((..((((((((...(.....)..)))))))))))).))))))).)))))).).)))))

Structure

u     c u      C       C    UA        gga g 
 gccgg c cugggU CCUGAGA CCUU  ACCUGUGA   c u
 ||||| | |||||| ||||||| ||||  ||||||||   | c
 cgguc g gguCCG GGGUUCU GGAG  UGGACAcu   g c
-     c c      A       U    --        -gg a 

Annotation confidence High

Comments

The mature sequence shown here represents the most commonly cloned form from large-scale cloning studies [3]. The ends of the miRNA may be offset with respect to previous annotations.

Genome context

chr1: 59704827-59704911 [+]

Clustered miRNAs

3 other miRNAs are < 10 kb from rno-mir-125a

Mature rno-miR-125a-5p

• Accession: MIMAT0000829
• Description: Rattus norvegicus rno-miR-125a-5p mature miRNA
• Sequence: 15 - UCCCUGAGACCCUUUAACCUGUGA - 38
• Evidence: experimental ; cloned [1-3], SOLiD [4]

Mature rno-miR-125a-3p

• Accession: MIMAT0004729
• Description: Rattus norvegicus rno-miR-125a-3p mature miRNA
• Sequence: 53 - ACAGGUGAGGUUCUUGGGAGCC - 74
• Evidence: experimental ; cloned [3], SOLiD [4]

References

1. PubMed ID: 17604727
   A mammalian microRNA expression atlas based on small RNA library sequencing
   "Landgraf P, Rusu M, Sheridan R, Sewer A, Iovino N, Aravin A, Pfeffer S, Rice A, Kamphorst AO, Landthaler M, Lin C, Socci ND, Hermida L, Fulci V, Chiaretti S, Foa R, Schliwka J, Fuchs U, Novosel A, Muller RU, Schermer B, Bissels U, Inman J, Phan Q, Chien M"
   "Cell (2007) 129:1401-1414


2. PubMed ID: 16766679
   Identification and characterization of two novel classes of small RNAs in the mouse germline: retrotransposon-derived siRNAs in oocytes and germline small RNAs in testes
   "Watanabe T, Takeda A, Tsukiyama T, Mise K, Okuno T, Sasaki H, Minami N, Imai H"
   "Genes Dev (2006) 20:1732-1743


3. PubMed ID: 20403161
   Small RNA expression and strain specificity in the rat
   Linsen SE, de Wit E, de Bruijn E, Cuppen E
   BMC Genomics (2010) 11:249


4. PubMed ID: 15345052
   Microarray analysis of microRNA expression in the developing mammalian brain
   Miska EA, Alvarez-Saavedra E, Townsend M, Yoshii A, Sestan N, Rakic P, Constantine-Paton M, Horvitz HR
   Genome Biol (2004) 5:R68