miRBase entry: hsa-mir-493

Stem-loop hsa-mir-493


Accession
MI0003132
Symbol
HGNC: MIR493
Description
Homo sapiens hsa-mir-493 precursor miRNA
Gene family
MIPF0000230; mir-493

Literature search
36 open access papers mention hsa-mir-493
(272 sentences)

Sequence

5046 reads, 96 reads per million, 85 experiments
cuggccuccagggcuUUGUACAUGGUAGGCUUUCAUUcauucguuugcacauucggUGAAGGUCUACUGUGUGCCAGGcccugugccag
(((((...((((((((.((((((((((((((((((((.................)))))))))))))))))))).)))))))).)))))

Structure
     cuc        U                    cauucgu 
cuggc   cagggcuU GUACAUGGUAGGCUUUCAUU       u
|||||   |||||||| ||||||||||||||||||||       u
gaccg   gucccGGA CGUGUGUCAUCUGGAAGUgg       g
     --u        C                    cuuacac 


Annotation confidence High
Do you think this miRNA is real?
Comments
The mature miRNA sequences were named miR-493-5p and miR-493-3p in [1,2] and here. Landgraf et al. showed that the 3' product is the predominant one [3]. The mature sequence shown here represents the most commonly cloned form from large-scale cloning studies [3].

Genome context
chr14: 100869060-100869148 [+]
Clustered miRNAs
2 other miRNAs are < 10 kb from hsa-mir-493
Name Accession Chromosome Start End Strand Confidence




Disease association
hsa-mir-493 is associated with one or more human diseases in the Human microRNA Disease Database
Disease Description Category PubMed ID


Database links

Mature hsa-miR-493-5p

Accession MIMAT0002813
Description Homo sapiens hsa-miR-493-5p mature miRNA
Sequence 16 - UUGUACAUGGUAGGCUUUCAUU - 37
Evidence experimental
array-cloned [1], cloned [2-3]
Database links
Predicted targets

Mature hsa-miR-493-3p

Accession MIMAT0003161
Description Homo sapiens hsa-miR-493-3p mature miRNA
Sequence 57 - UGAAGGUCUACUGUGUGCCAGG - 78
Evidence experimental
cloned [2-3]
Database links
Predicted targets

References

  1. PubMed ID: 17604727
    A mammalian microRNA expression atlas based on small RNA library sequencing
    "Landgraf P, Rusu M, Sheridan R, Sewer A, Iovino N, Aravin A, Pfeffer S, Rice A, Kamphorst AO, Landthaler M, Lin C, Socci ND, Hermida L, Fulci V, Chiaretti S, Foa R, Schliwka J, Fuchs U, Novosel A, Muller RU, Schermer B, Bissels U, Inman J, Phan Q, Chien M"
    "Cell (2007) 129:1401-1414

  2. PubMed ID: 15965474
    Identification of hundreds of conserved and nonconserved human microRNAs
    "Bentwich I, Avniel A, Karov Y, Aharonov R, Gilad S, Barad O, Barzilai A, Einat P, Einav U, Meiri E, Sharon E, Spector Y, Bentwich Z"
    "Nat Genet (2005) 37:766-770

  3. PubMed ID: 16274478
    Identification of clustered microRNAs using an ab initio prediction method
    Sewer A, Paul N, Landgraf P, Aravin A, Pfeffer S, Brownstein MJ, Tuschl T, van Nimwegen E, Zavolan M
    BMC Bioinformatics (2005) 6:267