Accession
MI0003161
Symbol
HGNC:
MIR517A
Description
Homo sapiens
hsa-mir-517a precursor miRNA
Gene family
MIPF0000020;
mir-515
Summary
Caution, this is an AI generated summary based on literature. This may have errors. ?
MIR517A is a placenta-specific miRNA that is only detected in certain types of mesenchymal stem cells (MSCs) [PMC5388876]. It has been shown that certain maternally derived miRNAs, including MIR517A, originate from the placenta, circulate in the mother's plasma, and are cleared shortly after delivery [PMC7468461]. In an individual from Tibet, MIR517A is found to be under copy number variations (CNVs) [PMC3938728]. Studies with BeWo cells have demonstrated that the syncytiotrophoblast (STB) is the main source of released MIR517A [PMC7465902]. In hepatocellular carcinoma (HCC), there are no significant differences in the expression of MIR517A between patients with and without preeclampsia (PE) [PMC4540200]. Furthermore, MIR517A expression has been detected in breast invasive carcinoma samples [PMC6193703]. It has been shown that MIR517A belongs to the C19MC cluster on chromosome 19 and has been associated with stem cell biology and tumorigenesis [PMC8508841]. In patients tested for RNA expression levels, both mir519d and MIR517A showed little to no expression, indicating correct pathological subtyping [PMC9623263]. References: - PMC5388876 - PMC7468461 - PMC3938728 - PMC7465902 - PMC4540200 - PMC6193703 - PMC8508841 - PMC9623263
Literature search
33 open access papers mention hsa-mir-517a
(190 sentences)
(190 sentences)
Sequence
224
reads,
19
reads per million, 28 experiments
ucucaggcagugacCCUCUAGAUGGAAGCACUGUCUguuguauaaaagaaaagAUCGUGCAUCCCUUUAGAGUGUuacuguuugaga
((((((((((((((.(((((((.(((.((((.((((...............)))).)))).))).))))))).))))))))))))))
((((((((((((((.(((((((.(((.((((.((((...............)))).)))).))).))))))).))))))))))))))
Structure
C U A U guugua
ucucaggcagugac CUCUAGA GGA GCAC GUCU u
|||||||||||||| ||||||| ||| |||| |||| a
agaguuugucauUG GAGAUUU CCU CGUG UAga a
U C A C aaagaa
Annotation confidence
Not enough data
Do you think this miRNA is real?
Comments
The mature sequence shown here represents the most commonly cloned form from large-scale cloning studies [2].
Genome context
chr19: 53712268-53712354 [+]
Clustered miRNAs
10 other miRNAs are < 10 kb from hsa-mir-517a
| Name | Accession | Chromosome | Start | End | Strand | Confidence |
|---|
Disease association
hsa-mir-517a is associated with one or more human diseases in the Human microRNA Disease Database
| Disease | Description | Category | PubMed ID |
|---|
Database links
Mature hsa-miR-517-5p
| Accession | MIMAT0002851 |
| Description | Homo sapiens hsa-miR-517-5p mature miRNA |
| Sequence | 15 - CCUCUAGAUGGAAGCACUGUCU - 36 |
| Evidence |
experimental
array-cloned [1] |
Mature hsa-miR-517a-3p
| Accession | MIMAT0002852 |
| Description | Homo sapiens hsa-miR-517a-3p mature miRNA |
| Sequence | 54 - AUCGUGCAUCCCUUUAGAGUGU - 75 |
| Evidence |
experimental
array-cloned [1], cloned [2] |
| Database links |
|
| Predicted targets |
|
References
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