Stem-loop hsa-mir-520d

Accession

MI0003164

Symbol

HGNC: MIR520D

Description

Homo sapiens hsa-mir-520d precursor miRNA

Literature search

54 open access papers mention hsa-mir-520d
(190 sentences)

Sequence

22 reads, 1 reads per million, 9 experiments

ucucaagcugugaguCUACAAAGGGAAGCCCUUUCuguugucuaaaagaaaagAAAGUGCUUCUCUUUGGUGGGUuacgguuugaga
(((((((((((((.((..(((((((((((.((((((....(((...)))..)))))).)))))))))))..)).)))))))))))))

Structure

             g  UA           C      guug   a 
ucucaagcuguga uC  CAAAGGGAAGC CUUUCu    ucu  
||||||||||||| ||  ||||||||||| ||||||    ||| a
agaguuuggcauU GG  GUUUCUCUUCG GAAAga    aga  
             G  UG           U      --aa   a 

Annotation confidence Low

Comments

The mature products were previously named miR-520d and miR-520d* here and in [1]. Landgraf et al. show that both products may be significantly expressed [2]. They are therefore renamed miR-520d-5p and miR-520d-3p. The mature sequence shown here represents the most commonly cloned form from large-scale cloning studies [2]. The 5' end of the miRNA may be offset with respect to previous annotations.

Genome context

chr19: 53720096-53720182 [+]

Clustered miRNAs

9 other miRNAs are < 10 kb from hsa-mir-520d

Disease association

hsa-mir-520d is associated with one or more human diseases in the Human microRNA Disease Database

Mature hsa-miR-520d-5p

• Accession: MIMAT0002855
• Description: Homo sapiens hsa-miR-520d-5p mature miRNA
• Sequence: 16 - CUACAAAGGGAAGCCCUUUC - 35
• Evidence: experimental ; array-cloned [1], cloned [2]

Mature hsa-miR-520d-3p

• Accession: MIMAT0002856
• Description: Homo sapiens hsa-miR-520d-3p mature miRNA
• Sequence: 54 - AAAGUGCUUCUCUUUGGUGGGU - 75
• Evidence: experimental ; array-cloned [1], cloned [2]

References

1. PubMed ID: 17604727
   A mammalian microRNA expression atlas based on small RNA library sequencing
   "Landgraf P, Rusu M, Sheridan R, Sewer A, Iovino N, Aravin A, Pfeffer S, Rice A, Kamphorst AO, Landthaler M, Lin C, Socci ND, Hermida L, Fulci V, Chiaretti S, Foa R, Schliwka J, Fuchs U, Novosel A, Muller RU, Schermer B, Bissels U, Inman J, Phan Q, Chien M"
   "Cell (2007) 129:1401-1414


2. PubMed ID: 15965474
   Identification of hundreds of conserved and nonconserved human microRNAs
   "Bentwich I, Avniel A, Karov Y, Aharonov R, Gilad S, Barad O, Barzilai A, Einat P, Einav U, Meiri E, Sharon E, Spector Y, Bentwich Z"
   "Nat Genet (2005) 37:766-770