miRBase entry: hsa-mir-551b

Stem-loop hsa-mir-551b


Accession
MI0003575
Symbol
HGNC: MIR551B
Description
Homo sapiens hsa-mir-551b precursor miRNA
Gene family
MIPF0000360; mir-551

Summary
Caution, this is an AI generated summary based on literature. This may have errors. ?

MIR551B is a microRNA that has been studied to determine its putative targets. Web-based tools like miRanda and Targetscan were used to predict potential targets, and it was found that the 3'-UTR of ZEB1 is a potential target of MIR551B [PMC6563032]. Additionally, it was acknowledged that MIR551B may also activate the promoters of certain target genes [PMC6563032].

Literature search
20 open access papers mention hsa-mir-551b
(36 sentences)

Sequence

15819 reads, 204 reads per million, 64 experiments
agaugugcucuccuggcccauGAAAUCAAGCGUGGGUGAGACCuggugcagaacgggaagGCGACCCAUACUUGGUUUCAGaggcugugagaauaa
........((((.(((((..((((((((((.((((((....((((........))))......)))))).))))))))))..))))).))))....

Structure
agaugugc    c     ca          C      --GAGA    gug 
        ucuc uggcc  uGAAAUCAAG GUGGGU      CCug   c
        |||| |||||  |||||||||| ||||||      ||||    
        agag gucgg  ACUUUGGUUC UACCCA      gggc   a
----aaua    u     aG          A      GCGgaa    aag 


Annotation confidence High
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Genome context
chr3: 168551854-168551949 [+]

Disease association
hsa-mir-551b is associated with one or more human diseases in the Human microRNA Disease Database
Disease Description Category PubMed ID


Database links

Mature hsa-miR-551b-5p

Accession MIMAT0004794
Description Homo sapiens hsa-miR-551b-5p mature miRNA
Sequence 22 - GAAAUCAAGCGUGGGUGAGACC - 43
Evidence experimental
cloned [2]
Database links
Predicted targets

Mature hsa-miR-551b-3p

Accession MIMAT0003233
Description Homo sapiens hsa-miR-551b-3p mature miRNA
Sequence 61 - GCGACCCAUACUUGGUUUCAG - 81
Evidence experimental
Microarray [1], RT-PCR [1], SAGE [1], cloned [2]
Database links
Predicted targets

References

  1. PubMed ID: 17604727
    A mammalian microRNA expression atlas based on small RNA library sequencing
    "Landgraf P, Rusu M, Sheridan R, Sewer A, Iovino N, Aravin A, Pfeffer S, Rice A, Kamphorst AO, Landthaler M, Lin C, Socci ND, Hermida L, Fulci V, Chiaretti S, Foa R, Schliwka J, Fuchs U, Novosel A, Muller RU, Schermer B, Bissels U, Inman J, Phan Q, Chien M"
    "Cell (2007) 129:1401-1414

  2. PubMed ID: 16505370
    The colorectal microRNAome
    "Cummins JM, He Y, Leary RJ, Pagliarini R, Diaz LA Jr, Sjoblom T, Barad O, Bentwich Z, Szafranska AE, Labourier E, Raymond CK, Roberts BS, Juhl H, Kinzler KW, Vogelstein B, Velculescu VE"
    "Proc Natl Acad Sci U S A (2006) 103:3687-3692