Stem-loop mmu-mir-216b

Accession

MI0004126

Symbol

MGI: Mir216b

Description

Mus musculus mmu-mir-216b precursor miRNA mir-216

Gene
family

RF00654; mir-216

Literature search

24 open access papers mention mmu-mir-216b
(81 sentences)

Sequence

11392 reads, 94 reads per million, 37 experiments

uuggcagacugggAAAUCUCUGCAGGCAAAUGUGAugucacugaagaaaccacACACUUACCUGUAGAGAUUCUUcagucugacaa
.((.(((((((((.((((((((((((.((.((((.((((......))...)))))).)).)))))))))))).))))))))).)).

Structure

u  g         A            C  A    A  ---  ac 
 ug cagacuggg AAUCUCUGCAGG AA UGUG ug   uc  u
 || ||||||||| |||||||||||| || |||| ||   ||   
 ac gucugacUU UUAGAGAUGUCC UU ACAc ac   ag  g
a  a         C            A  C    -  caa  aa 

Annotation confidence High

Comments

The mature sequence shown here represents the most commonly cloned form from large-scale cloning studies [2]. The 5' end of the miRNA may be offset with respect to previous annotations.

Genome context

chr11: 28746191-28746276 [+]

Clustered miRNAs

1 other miRNA is < 10 kb from mmu-mir-216b

Mature mmu-miR-216b-5p

• Accession: MIMAT0003729
• Description: Mus musculus mmu-miR-216b-5p mature miRNA
• Sequence: 14 - AAAUCUCUGCAGGCAAAUGUGA - 35
• Evidence: experimental ; MPSS [1], cloned [2], Illumina [3-4]

Mature mmu-miR-216b-3p

• Accession: MIMAT0017233
• Description: Mus musculus mmu-miR-216b-3p mature miRNA
• Sequence: 54 - ACACUUACCUGUAGAGAUUCUU - 75
• Evidence: experimental ; Illumina [4]

References

1. PubMed ID: 17604727
   A mammalian microRNA expression atlas based on small RNA library sequencing
   "Landgraf P, Rusu M, Sheridan R, Sewer A, Iovino N, Aravin A, Pfeffer S, Rice A, Kamphorst AO, Landthaler M, Lin C, Socci ND, Hermida L, Fulci V, Chiaretti S, Foa R, Schliwka J, Fuchs U, Novosel A, Muller RU, Schermer B, Bissels U, Inman J, Phan Q, Chien M"
   "Cell (2007) 129:1401-1414


2. PubMed ID: 20215419
   MicroRNA transcriptome in the newborn mouse ovaries determined by massive parallel sequencing
   "Ahn HW, Morin RD, Zhao H, Harris RA, Coarfa C, Chen ZJ, Milosavljevic A, Marra MA, Rajkovic A"
   "Mol Hum Reprod (2010) 16:463-471


3. PubMed ID: 20413612
   Mammalian microRNAs: experimental evaluation of novel and previously annotated genes
   "Chiang HR, Schoenfeld LW, Ruby JG, Auyeung VC, Spies N, Baek D, Johnston WK, Russ C, Luo S, Babiarz JE, Blelloch R, Schroth GP, Nusbaum C, Bartel DP"
   "Genes Dev (2010) 24:992-1009


4. PubMed ID: 16582102
   The expression profile of microRNAs in mouse embryos
   "Mineno J, Okamoto S, Ando T, Sato M, Chono H, Izu H, Takayama M, Asada K, Mirochnitchenko O, Inouye M, Kato I"
   "Nucleic Acids Res (2006) 34:1765-1771