miRBase entry: hsa-mir-675

Stem-loop hsa-mir-675


Accession
MI0005416
Symbol
HGNC: MIR675
Description
Homo sapiens hsa-mir-675 precursor miRNA
Gene family
MIPF0000365; mir-675

Summary
Caution, this is an AI generated summary based on literature. This may have errors. ?

MIR675 is a long non-coding RNA (lncRNA) that has been studied in tumors. In a study, it was found that knockdown of MIR675 in tumors resulted in a significantly lower percentage of Ki67 positive cells compared to control tumors [PMC4741653]. However, the role of lncRNA H19 or MIR675 has not been investigated in patients with heterotopic ossification (HO) or mouse models of HO formation [PMC9753082].

Literature search
106 open access papers mention hsa-mir-675
(931 sentences)

Sequence

1153 reads, 141 reads per million, 58 experiments
cccagggucUGGUGCGGAGAGGGCCCACAGUGgacuuggugacgCUGUAUGCCCUCACCGCUCAgccccuggg
(((((((.((((.((((.((((((..((((((..........))))))..)))))).)))))))).)))))))

Structure
       u    U    A      CC      gacu 
cccaggg cUGG GCGG GAGGGC  ACAGUG    u
||||||| |||| |||| ||||||  ||||||     
ggguccc gACU CGCC CUCCCG  UGUCgc    g
       c    -    A      UA      agug 


Annotation confidence High
Do you think this miRNA is real?

Genome context
chr11: 1996759-1996831 [-]

Disease association
hsa-mir-675 is associated with one or more human diseases in the Human microRNA Disease Database
Disease Description Category PubMed ID

Biological pathways
hsa-mir-675 is involved in one or more biological pathways:
(Source: Reactome)
Biological reactions
hsa-mir-675 is involved in one or more regulation/signalling events:
(Source: Reactome)

Database links

Mature hsa-miR-675-5p

Accession MIMAT0004284
Description Homo sapiens hsa-miR-675-5p mature miRNA
Sequence 10 - UGGUGCGGAGAGGGCCCACAGUG - 32
Evidence experimental
cloned [1]
Database links
Predicted targets

Mature hsa-miR-675-3p

Accession MIMAT0006790
Description Homo sapiens hsa-miR-675-3p mature miRNA
Sequence 45 - CUGUAUGCCCUCACCGCUCA - 64
Evidence experimental
cloned [2]
Database links
Predicted targets

References

  1. PubMed ID: 18402656
    Hidden layers of human small RNAs
    Kawaji H, Nakamura M, Takahashi Y, Sandelin A, Katayama S, Fukuda S, Daub CO, Kai C, Kawai J, Yasuda J, Carninci P, Hayashizaki Y
    BMC Genomics (2008) 9:157

  2. PubMed ID: 17237358
    The imprinted H19 noncoding RNA is a primary microRNA precursor
    "Cai X, Cullen BR"
    "RNA (2007) 13:313-316