Stem-loop hsa-mir-885

Accession

MI0005560

Symbol

HGNC: MIR885

Description

Homo sapiens hsa-mir-885 precursor miRNA

Gene family

MIPF0000532; mir-885

Summary

Caution, this is an AI generated summary based on literature. This may have errors.

MIR885 is a miRNA that has been implicated in various biological processes and diseases. It is a negative regulator of autophagy and has been shown to target genes involved in autophagy, such as ULK1, BECN1, RAB5A, and RB1CC1 [PMC4990999]. In addition, MIR885 has been found to be downregulated in sFRP4 SI cells and upregulated in sFRP4 OE treated cells [PMC6356444]. It has also been shown to be upregulated in CRC cell lines and stimulates migration while downregulating IGFBP-5 [PMC9203274]. MIR885 can suppress ISRE activities induced by IFN-α stimulation [PMC3434395]. Furthermore, MIR885 is involved in the interplay with p73ΔEx2/3 to enhance stemness and self-renewal capacity in less invasive melanoma cells [PMC7765507]. Differential methylation of CG dinucleotides in the promoter regions of MIR885 has also been reported, which might influence its expression [PMC9847511]. Moreover, MIR885 has been implicated as a tumor suppressor miRNA that targets CD276 (B7-H3) and IGFR [PMC4697439] [PMC8506118]. Overall, these findings highlight the diverse roles of MIR885 in various biological processes and its potential as a therapeutic target.

Literature search

38 open access papers mention hsa-mir-885
(236 sentences)

Sequence

1421 reads, 59 reads per million, 69 experiments

ccgcacucucUCCAUUACACUACCCUGCCUCUucuccaugagAGGCAGCGGGGUGUAGUGGAUAgagcacgggu
(((..((((.(((((((((((.(((((((((((......))))))))).))))))))))))).))))..)))..

Structure

--   ca    c           A  -         cu 
  ccg  cucu UCCAUUACACU CC CUGCCUCUu  c
  |||  |||| ||||||||||| || |||||||||   
  ggc  gagA AGGUGAUGUGG GG GACGGAgag  c
ug   ac    U           -  C         ua 

Annotation confidence High

Comments

This sequence was identified as a miRNA candidate by Berezikov et al. using RAKE and MPSS techniques [1]. Expression was later confirmed by cloning [2].

Genome context

chr3: 10394489-10394562 [-]

Disease association

hsa-mir-885 is associated with one or more human diseases in the Human microRNA Disease Database

Mature hsa-miR-885-5p

• Accession: MIMAT0004947
• Description: Homo sapiens hsa-miR-885-5p mature miRNA
• Sequence: 11 - UCCAUUACACUACCCUGCCUCU - 32
• Evidence: experimental ; cloned [2]

Mature hsa-miR-885-3p

• Accession: MIMAT0004948
• Description: Homo sapiens hsa-miR-885-3p mature miRNA
• Sequence: 43 - AGGCAGCGGGGUGUAGUGGAUA - 64
• Evidence: experimental ; cloned [2]

References

1. PubMed ID: 17604727
   A mammalian microRNA expression atlas based on small RNA library sequencing
   "Landgraf P, Rusu M, Sheridan R, Sewer A, Iovino N, Aravin A, Pfeffer S, Rice A, Kamphorst AO, Landthaler M, Lin C, Socci ND, Hermida L, Fulci V, Chiaretti S, Foa R, Schliwka J, Fuchs U, Novosel A, Muller RU, Schermer B, Bissels U, Inman J, Phan Q, Chien M"
   "Cell (2007) 129:1401-1414


2. PubMed ID: 16954537
   Many novel mammalian microRNA candidates identified by extensive cloning and RAKE analysis
   "Berezikov E, van Tetering G, Verheul M, van de Belt J, van Laake L, Vos J, Verloop R, van de Wetering M, Guryev V, Takada S, van Zonneveld AJ, Mano H, Plasterk R, Cuppen E"
   "Genome Res (2006) 16:1289-1298