Stem-loop hsa-mir-374b

Accession

MI0005566

Symbol

HGNC: MIR374B

Description

Homo sapiens hsa-mir-374b precursor miRNA

Summary

Caution, this is an AI generated summary based on literature. This may have errors.

MIR374B, a microRNA, exhibits differential expression patterns in various cell types and disease states. In naïve mesenchymal stem cells (MSCs), MIR374B expression is significantly higher compared to primed MSCs [PMC9509608]. It is implicated in the regulation of chemokines such as Cxcl1, Ccl2, and Ccl7, which may influence the development of AMA by targeting these molecules [PMC5712098]. MIR374B overexpression in B cells within the Chinese population has been linked to increased B-cell proliferation and altered IgA1 galactosylation [PMC6834307]. It also plays a role in cancer by targeting PD-1 to modulate T cell function [PMC6833224]. In vascular tissues, MIR374B levels vary with low expression at atheroprotected sites and higher expression at atheroprone regions within endothelial cells [PMC6590197]. Downregulation of MIR374B has been associated with the P-phase of cell cycle regulation [PMC7376782], and its increased levels have been correlated with improved survival outcomes in cancer patients treated with regorafenib [PMC9589420]. Furthermore, MIR374B targets genes such as RECK and ZEB2 to inhibit cellular migration and invasion in bladder cancer [PMC7783806]'>PMC7783806], while its differential methylation patterns have been observed in warts compared to normal skin [PMC7783806]. Lastly, ethnicity may influence MIR374B expression levels as seen in skin samples from Han Chinese individuals compared to Uyghurs [PMC7783806].

Literature search

60 open access papers mention hsa-mir-374b
(150 sentences)

Sequence

261515 reads, 1430 reads per million, 144 experiments

acucggauggAUAUAAUACAACCUGCUAAGUGuccuagcaCUUAGCAGGUUGUAUUAUCAUUguccgugucu
((.(((((((..(((((((((((((((((((((....)))))))))))))))))))))..))))))).))..

Structure

--  u       AU                     c 
  ac cggaugg  AUAAUACAACCUGCUAAGUGu c
  || |||||||  |||||||||||||||||||||  
  ug gccugUU  UAUUAUGUUGGACGAUUCacg u
uc  u       AC                     a 

Annotation confidence High

Comments

This sequence was identified as a miRNA candidate by Berezikov et al. using RAKE and MPSS techniques [1]. Expression was later confirmed by cloning [2].

Genome context

chrX: 74218547-74218618 [-]

Clustered miRNAs

2 other miRNAs are < 10 kb from hsa-mir-374b

Disease association

hsa-mir-374b is associated with one or more human diseases in the Human microRNA Disease Database

Mature hsa-miR-374b-5p

• Accession: MIMAT0004955
• Description: Homo sapiens hsa-miR-374b-5p mature miRNA
• Sequence: 11 - AUAUAAUACAACCUGCUAAGUG - 32
• Evidence: experimental ; cloned [2-3]

Mature hsa-miR-374b-3p

• Accession: MIMAT0004956
• Description: Homo sapiens hsa-miR-374b-3p mature miRNA
• Sequence: 41 - CUUAGCAGGUUGUAUUAUCAUU - 62
• Evidence: experimental ; cloned [2]

References

1. PubMed ID: 17604727
   A mammalian microRNA expression atlas based on small RNA library sequencing
   "Landgraf P, Rusu M, Sheridan R, Sewer A, Iovino N, Aravin A, Pfeffer S, Rice A, Kamphorst AO, Landthaler M, Lin C, Socci ND, Hermida L, Fulci V, Chiaretti S, Foa R, Schliwka J, Fuchs U, Novosel A, Muller RU, Schermer B, Bissels U, Inman J, Phan Q, Chien M"
   "Cell (2007) 129:1401-1414


2. PubMed ID: 17616659
   Patterns of known and novel small RNAs in human cervical cancer
   "Lui WO, Pourmand N, Patterson BK, Fire A"
   "Cancer Res (2007) 67:6031-6043


3. PubMed ID: 16954537
   Many novel mammalian microRNA candidates identified by extensive cloning and RAKE analysis
   "Berezikov E, van Tetering G, Verheul M, van de Belt J, van Laake L, Vos J, Verloop R, van de Wetering M, Guryev V, Takada S, van Zonneveld AJ, Mano H, Plasterk R, Cuppen E"
   "Genome Res (2006) 16:1289-1298