Accession
MI0005756
Symbol
HGNC:
MIR934
Description
Homo sapiens
hsa-mir-934 precursor miRNA
Gene family
MIPF0000542;
mir-934
Summary
Caution, this is an AI generated summary based on literature. This may have errors. ?
MIR934 is a microRNA that has been studied for its role in various biological processes. One study found that a single nucleotide polymorphism (SNP) in MIR934, specifically n.15T>G in the 1st nucleotide in the 5p strand, resulted in altered DROSHA/DICER1 cleavage sites and the generation of a novel miRNA called isomiR [PMC9708458]. To validate the bioinformatics data for target prediction, luciferase assays were conducted to assess the interaction between MIR934 and two target genes, TFCP2L1 or RAB3B [PMC7295570]. In silico analysis and dual luciferase assays confirmed that MIR934 binds to specific sites on the 3'-UTR of FZD5, TFCP2L1, and RAB3B [PMC7295570]. The binding sites of MIR934 on FZD5 were found to be conserved across different species [PMC7295570]. Co-transfection experiments confirmed the binding of MIR934 to these target mRNAs [PMC7295570]. In another study, miR-934 knockdown was achieved using a MIR934 inhibitor to investigate its effect on cell proliferation and cell cycle in colorectal cancer (CRC) cells [PMC8809948]. The levels of circRNF10 and MIR934 were measured using specific primers [PMC9739140]. These findings highlight the functional significance of MIR934 and its potential role in various biological processes.
Literature search
5 open access papers mention hsa-mir-934
(8 sentences)
(8 sentences)
Sequence
297
reads,
11
reads per million, 43 experiments
agaaauaaggcuucUGUCUACUACUGGAGACACUGGuaguauaaaacccagagucuccaguaauggacgggagccuuauuucu
((((((((((((((((((((.((((((((((.((((...........)))).)))))))))).))))))))))))))))))))
((((((((((((((((((((.((((((((((.((((...........)))).)))))))))).))))))))))))))))))))
Structure
C A uagu
agaaauaaggcuucUGUCUA UACUGGAGAC CUGG a
|||||||||||||||||||| |||||||||| |||| u
ucuuuauuccgagggcaggu augaccucug gacc a
a a caaa
Annotation confidence
Not enough data
Do you think this miRNA is real?
Genome context
chrX: 136550878-136550960 [+]
Disease association
hsa-mir-934 is associated with one or more human diseases in the Human microRNA Disease Database
| Disease | Description | Category | PubMed ID |
|---|
Database links
Mature hsa-miR-934
| Accession | MIMAT0004977 |
| Description | Homo sapiens hsa-miR-934 mature miRNA |
| Sequence | 15 - UGUCUACUACUGGAGACACUGG - 36 |
| Evidence |
experimental
cloned [1] |
| Database links |
|
| Predicted targets |
|
References
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