Accession
MI0006355
Symbol
HGNC:
MIR1293
Description
Homo sapiens
hsa-mir-1293 precursor miRNA
Gene family
MIPF0000691;
mir-1293
Summary
Caution, this is an AI generated summary based on literature. This may have errors. ?
MIR1293 is a microRNA that has been studied in the context of lung adenocarcinoma (LUAD). Univariate Cox regression analysis has shown that high expression of MIR1293 is associated with poor survival outcomes in LUAD [PMC7212445]. In contrast, high expression of LINC01740, another gene in the ceRNA network, is associated with good survival outcomes [PMC7212445]. In a combined step regression and Cox regression analysis, MIR1293 was identified as one of four genes that serve as prognostic biomarkers in LUAD [PMC7212445]. Furthermore, MIR1293 was found to be a novel important prognostic factor involved in LUAD pathogenesis [PMC7212445]. In a study comparing expression levels between high-risk and low-risk groups, it was observed that the expression level of MIR1293 was higher in the high-risk group [PMC7212445]. Additionally, MIR1293 has been shown to be involved in the regulation of vIL-6 and hIL-6 through binding sites in their open reading frames (ORF) [PMC9495386]. Expression deregulation patterns of several miRNAs, including MIR1293, have been observed in leukoplakia and leukoplakia-transformed cancer tissues [PMC5011738]. References: - [PMC7212445]: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7212445/ - [PMC9495386]: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9495386/ - [PMC5011738]: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5011738/
Literature search
6 open access papers mention hsa-mir-1293
(9 sentences)
(9 sentences)
Sequence
178
reads,
164
reads per million, 38 experiments
agguuguucUGGGUGGUCUGGAGAUUUGUGCagcuuguaccugcacaaaucuccggaccacuuagucuuua
........(((((((((((((((((((((((((.......)))))))))))))))))))))))))......
........(((((((((((((((((((((((((.......)))))))))))))))))))))))))......
Structure
agguuguu cu
cUGGGUGGUCUGGAGAUUUGUGCag u
||||||||||||||||||||||||| g
gauucaccaggccucuaaacacguc u
--auuucu ca
Annotation confidence
Not enough data
Do you think this miRNA is real?
Genome context
chr12: 50234142-50234212 [-]
Disease association
hsa-mir-1293 is associated with one or more human diseases in the Human microRNA Disease Database
| Disease | Description | Category | PubMed ID |
|---|
Database links
Mature hsa-miR-1293
| Accession | MIMAT0005883 |
| Description | Homo sapiens hsa-miR-1293 mature miRNA |
| Sequence | 10 - UGGGUGGUCUGGAGAUUUGUGC - 31 |
| Evidence |
experimental
Illumina [1] |
| Database links |
|
| Predicted targets |
|
References
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