Stem-loop hsa-mir-1256

Accession

MI0006390

Symbol

HGNC: MIR1256

Description

Homo sapiens hsa-mir-1256 precursor miRNA mir-1256

Gene
family

RF04066; mir-1256

Summary

Caution, this is an AI generated summary based on literature. This may have errors.

MIR1256 is a microRNA implicated in prostate cancer [PMC7920560]. It was one of the miRNAs overexpressed in ameloblastoma tumors identified by microarray analysis [PMC5354851]. However, when MIR1256 was selected for validation through stem loop qPCR, its expression was found to be inconsistent among ameloblastoma and non-ameloblastoma controls [PMC5354851]. In the context of cancer progression, MIR1256 has been associated with alterations in gastric, thyroid, and brain cancers [PMC9775590]. Interactome analysis has shown that MIR1256 can bind to circHECTD1 with the involvement of the Ago2 complex [PMC7216265]. In a study examining genetic alterations in patients with various cancers, gains covering MIR1256 were observed in some patients [PMC9775590], and it was noted that the hazard ratio (HR) for alterations was less than one for MIR1256 [PMC8108987], suggesting a complex role in cancer biology.

Literature search

4 open access papers mention hsa-mir-1256
(5 sentences)

Sequence

1430 reads, 12 reads per million, 58 experiments

agucagccuguugaagcuuugaagcuuugaugccAGGCAUUGACUUCUCACUAGCUgugaaaguccuagcuaaagagaagucaaugcaugacaucuuguuucaauagauggcuguuuca
(((((..((((((((((...........((((.((.(((((((((((((..((((((.((...)).))))))..))))))))))))).)).))))..)))))))))).)))))......

Structure

------     gc          uuugaagcuuu    c  G             AC      u  a 
      aguca  cuguugaagc           gaug cA GCAUUGACUUCUC  UAGCUg ga  
      |||||  ||||||||||           |||| || |||||||||||||  |||||| || a
      ucggu  gauaacuuug           cuac gu cguaacugaagag  aucgau cu  
acuuug     -a          ---------uu    a  a             aa      c  g 

Annotation confidence Low

Genome context

chr1: 20988314-20988432 [-]

Disease association

hsa-mir-1256 is associated with one or more human diseases in the Human microRNA Disease Database

Mature hsa-miR-1256

• Accession: MIMAT0005907
• Description: Homo sapiens hsa-miR-1256 mature miRNA
• Sequence: 35 - AGGCAUUGACUUCUCACUAGCU - 56
• Evidence: experimental ; Illumina [1]

References

1. PubMed ID: 18285502
   Application of massively parallel sequencing to microRNA profiling and discovery in human embryonic stem cells
   "Morin RD, O'Connor MD, Griffith M, Kuchenbauer F, Delaney A, Prabhu AL, Zhao Y, McDonald H, Zeng T, Hirst M, Eaves CJ, Marra MA"
   "Genome Res (2008) 18:610-621