miRBase entry: hsa-mir-1275

Stem-loop hsa-mir-1275


Accession
MI0006415
Symbol
HGNC: MIR1275
Description
Homo sapiens hsa-mir-1275 precursor miRNA
Gene family
MIPF0000674; mir-1275

Summary
Caution, this is an AI generated summary based on literature. This may have errors. ?

MIR1275 is a functional microRNA coding gene that has been linked to coronary atherosclerosis [PMC7123062]. It has also been directly reported to participate in multiple sclerosis (MS) [PMC6871504]. In addition, probe cg03903398 targets MIR1275, making it an effective microRNA coding gene [PMC6871504'>PMC6871504]. MIR1275 is one of the four miRNAs that were found to be downregulated in a study on T1D patients, suggesting its involvement in immune regulation and beta cell function [PMC7989380]. Another meta-analysis of studies on T1D patients also identified MIR1275 as one of the miRNAs involved in immune regulation and insulin processing, suggesting its potential as a biomarker for T1D [PMC6768498]. Furthermore, MIR1275 has been found to be negatively correlated with mitochondrial membrane potential (MMP) suppression and associated genes [PMC8327461]. It has also been reported to be dysregulated in certain types of cancer and infection [PMC5865775]. Lastly, E6 stabilizes RACK1 through O-GlcNAcylation at Ser122 and inhibits MIR1275, which inhibits the LGALS1 gene that encodes galactin1, promoting tumor invasion and metastasis [PMC10006576].

References:
- PMC7123062
- PMC6871504
- PMC7989380
- PMC6768498
- PMC8327461
- PMC5865775
- PMC10006576

Literature search
33 open access papers mention hsa-mir-1275
(58 sentences)

Sequence

6111 reads, 359 reads per million, 147 experiments
ccucugugagaaaggguGUGGGGGAGAGGCUGUCuugugucuguaaguaugccaaacuuauuuuccccaaggcagaggga
(((((((...........((((((((((((...((((......))))...))).......)))))))))..)))))))..

Structure
--       gagaaaggguG         -------   UGU    ug 
  ccucugu           UGGGGGAGA       GGC   Cuug  u
  |||||||           |||||||||       |||   ||||   
  ggagacg           accccuuuu       ccg   gaau  c
ag       ---------ga         auucaaa   uau    gu 


Annotation confidence Not enough data
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Genome context
chr6: 33999972-34000051 [-]

Disease association
hsa-mir-1275 is associated with one or more human diseases in the Human microRNA Disease Database
Disease Description Category PubMed ID


Database links

Mature hsa-miR-1275

Accession MIMAT0005929
Description Homo sapiens hsa-miR-1275 mature miRNA
Sequence 18 - GUGGGGGAGAGGCUGUC - 34
Evidence experimental
Illumina [1]
Database links
Predicted targets

References

  1. PubMed ID: 18285502
    Application of massively parallel sequencing to microRNA profiling and discovery in human embryonic stem cells
    "Morin RD, O'Connor MD, Griffith M, Kuchenbauer F, Delaney A, Prabhu AL, Zhao Y, McDonald H, Zeng T, Hirst M, Eaves CJ, Marra MA"
    "Genome Res (2008) 18:610-621