miRBase entry: hsa-mir-1306

Stem-loop hsa-mir-1306


Accession
MI0006443
Symbol
HGNC: MIR1306
Description
Homo sapiens hsa-mir-1306 precursor miRNA
Gene family
MIPF0000531; mir-1306

Summary
Caution, this is an AI generated summary based on literature. This may have errors. ?

MIR1306 is a miRNA that has been found to be expressed in the brain, and it is conserved in mice [PMC4487986]. After IFN-γ stimulation, MIR1306 is one of the top 10 miRNAs that are upregulated [PMC8010072]. MIR1306 is highly expressed in reproductive organs, including the uterus and vagina, suggesting a potential role in abnormal pregnancy outcomes [PMC8645989]. It has been shown to inhibit the production of proinflammatory cytokines such as NF-κB and IL-1β [PMC8155903]. MIR1306 affects downstream cytokine expression by targeting key genes in the TLR4 pathway [PMC8155903]. The MIR1306 gene overlaps with the DGCR8 coding region and is conserved in primates [PMC7357559]. In studies based on the GSE94462 dataset, MIR1306 was among several miRNAs identified [PMC9922242]. It has also been reported as one of the most frequently affected miRNA genes in CAKUT CNVs, supporting its potential role in CAKUT [PMC9587983]. Among six identified miRNAs, only miR1226 showed statistically significant differences compared to controls [PMC6764711].

Literature search
13 open access papers mention hsa-mir-1306
(54 sentences)

Sequence

4710 reads, 100 reads per million, 97 experiments
gugagcagucuccaCCACCUCCCCUGCAAACGUCCAguggugcagagguaauggACGUUGGCUCUGGUGGUGauggacaguccga
.((.((.((((.(((((((......((.((((((((.((.(.....).)).)))))))).))...)))))))..)))).)).)).

Structure
g  a  a    -c       UCCCCU  A        g  g g 
 ug gc gucu  caCCACC      GC AACGUCCA ug u c
 || || ||||  |||||||      || |||||||| || | a
 gc ug cagg  GUGGUGG      CG UUGCAggu au g g
a  c  a    ua       ---UCU  G        a  g a 


Annotation confidence High
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Genome context
chr22: 20086058-20086142 [+]
Clustered miRNAs
1 other miRNA is < 10 kb from hsa-mir-1306
Name Accession Chromosome Start End Strand Confidence




Disease association
hsa-mir-1306 is associated with one or more human diseases in the Human microRNA Disease Database
Disease Description Category PubMed ID


Database links

Mature hsa-miR-1306-3p

Accession MIMAT0005950
Description Homo sapiens hsa-miR-1306-3p mature miRNA
Sequence 55 - ACGUUGGCUCUGGUGGUG - 72
Evidence experimental
Illumina [1]
Database links
Predicted targets

Mature hsa-miR-1306-5p

Accession MIMAT0022726
Description Homo sapiens hsa-miR-1306-5p mature miRNA
Sequence 15 - CCACCUCCCCUGCAAACGUCCA - 36
Evidence not_experimental
Database links
Predicted targets

References

  1. PubMed ID: 18285502
    Application of massively parallel sequencing to microRNA profiling and discovery in human embryonic stem cells
    "Morin RD, O'Connor MD, Griffith M, Kuchenbauer F, Delaney A, Prabhu AL, Zhao Y, McDonald H, Zeng T, Hirst M, Eaves CJ, Marra MA"
    "Genome Res (2008) 18:610-621