Stem-loop hsa-mir-4511

Accession

MI0016877

Symbol

HGNC: MIR4511

Description

Homo sapiens hsa-mir-4511 precursor miRNA

Summary

Caution, this is an AI generated summary based on literature. This may have errors.

Hsa-mir-4511 is a microRNA that has been studied in various contexts. In a study, it was found that hsa-mir-4511 had increased levels compared to other microRNAs [PMC8199419]. Another study identified hsa-mir-4511 as one of the three muscle-related microRNAs in a miRNA-mRNA network [PMC8325595]. Hsa-mir-4511 was also found to target TLR1, a gene involved in the immune response [PMC9526608]. In patients with class IV lupus nephritis, hsa-mir-4511 was found to be increased in peripheral blood [PMC9618628]. Additionally, a variant called rs34089864 was found to affect the binding sites of hsa-mir-4511 and create new binding sites for other microRNAs [PMC5842303]. Overall, hsa-mir-4511 is one of the 24 novel differentially abundant microRNAs identified in patients with class IV lupus nephritis and has potential as a diagnostic biomarker for this condition [PMC5685598].

Literature search

2 open access papers mention hsa-mir-4511
(3 sentences)

Sequence

134 reads, 17 reads per million, 30 experiments

aaaaaaaagggaaaGAAGAACUGUUGCAUUUGCCCUgcacucaguuugcacaggguaaaugcaauaguucuucuuucccuuuuuuua
.((((((((((((((((((((((((((((((((((((..(.......)..)))))))))))))))))))))))))))))))))))).

Structure

a                                    ca uc 
 aaaaaaagggaaaGAAGAACUGUUGCAUUUGCCCUg  c  a
 ||||||||||||||||||||||||||||||||||||  |  g
 uuuuuuucccuuucuucuugauaacguaaaugggac  g  u
a                                    ac uu 

Annotation confidence Not enough data

Genome context

chr15: 65719246-65719332 [-]

Mature hsa-miR-4511

• Accession: MIMAT0019048
• Description: Homo sapiens hsa-miR-4511 mature miRNA
• Sequence: 15 - GAAGAACUGUUGCAUUUGCCCU - 36
• Evidence: experimental ; Illumina [1-2], qPCR [2]

References

1. PubMed ID: 20733160
   Deep sequencing of the small RNA transcriptome of normal and malignant human B cells identifies hundreds of novel microRNAs
   "Jima DD, Zhang J, Jacobs C, Richards KL, Dunphy CH, Choi WW, Au WY, Srivastava G, Czader MB, Rizzieri DA, Lagoo AS, Lugar PL, Mann KP, Flowers CR, Bernal-Mizrachi L, Naresh KN, Evens AM, Gordon LI, Luftig M, Friedman DR, Weinberg JB, Thompson MA, Gill JI,"
   "Blood (2010) 116:e118-e127


2. PubMed ID: 21785231
   Detection of novel human MiRNAs responding to X-ray irradiation
   "Ding N, Wu X, He J, Chang L, Hu W, Li W, Wang J, Wang T, Zhou G"
   "J Radiat Res (2011) 52:425-432