sort by

61 publications mentioning mmu-mir-191

Open access articles that are associated with the species Mus musculus and mention the gene name mir-191. Click the [+] symbols to view sentences that include the gene name, or the word cloud on the right for a summary.

1
[+] score: 52
While this miRNA has not been extensively researched, some studies have reported that miR-191-5p was up-regulated in major depressive disorders and down-regulated in Alzheimer’s disease (AD) [57]. [score:9]
Among altered miRNAs, miR-183/96/182 cluster and miR-191-5p both target and downregulate BDNF. [score:6]
Chemotherapy treatment of TNBC and PR+BC-bearing animals led to further alterations in the miRNAome, and amongst differentially expressed miRNAs, miR-191-5p was up-regulated in all experimental groups (tumor-bearing treated and untreated groups, as compared to intact controls). [score:5]
BDNF is also a target of miR-191 that was upregulated in all experimental animal groups, as compared to controls [51]. [score:5]
Among those, miR-191-5p was up-regulated in both TNBC and PR+BC tumor-bearing groups (Figure 2). [score:4]
Based on that, a potential next step is analyzing the links, if any, between miR-191-5p expression and inflammation in chemo brain and tumor brain - especially in light of evidence revealing the role of inflammation in chemo brain [60]. [score:3]
Two miRNAs (miR-191-5p and miR-100-5p) were up-regulated in TNBC and TNBC/DCP animals, as compared to intact controls (Figure 3). [score:3]
MiR-191-5p was up-regulated in all animal groups. [score:3]
We noted a commonality between all three groups (PR+BC, PR+BC/CRIZ, and PR+BC/TOP): miR 200 family (miR-200a, miR-200b, miR-200c, miR-141, and miR-429), miR-183/96/182 cluster, miR-30d-5p, and miR-191-5p were up-regulated, as compared to intact controls. [score:3]
Along with miR-191-5p, miR-100-5p was upregulated in TNBC animals and TNBC/DCP animals, as compared to intact controls. [score:3]
MiR-191-5p is one of the biomarkers of aging -associated Alzheimer’s disease. [score:2]
Interestingly, miR-191 was recently reported to be a regulator of brain-derived neurotrophic factor (BDNF) [51]. [score:2]
New studies reported the role of miR-191-5p in systemic inflammatory response syndrome [59]. [score:1]
This would help to better discern miR-191-5p’s roles in tumor brain and chemo brain as a potential molecular driver and biomarker of the two phenomena. [score:1]
Likewise, it would help determine if there exists any long-distance signalling between the tumor and the brain that involves miR-191-5p or any other mRNAs. [score:1]
Therefore, it would be interesting to analyse the levels of miR-191-5p in the plasma and whole blood of tumor brain and chemo brain animals. [score:1]
[1 to 20 of 16 sentences]
2
[+] score: 38
We performed microarray analysis of miRNA expression of glioma cells silenced for TALNEC2 and found that silencing of TALNEC2 increased the expression of several tumor suppressor miRNAs such as miR-137, miR-124, miR-205, miR-7 and miR-492, whereas it decreased the expression of some oncomiRs such as miR-21, miR-155, miR-33b and miR-191. [score:9]
We found that silencing of TALNEC2 in U87 cells resulted in an increased expression of miRNAs associated with tumor suppression [38, 39] (e. g., let-7b, miR-7, miR-124, miR-137, miR-129-3p, miR-142-3p, miR-205, miR-376c, miR-492, miR-562 and miR-3144) and in a decrease in the expression of miRNAs associated with tumor promotion [38– 40] (e. g., miR-9, miR-21 miR-33b, miR-155, miR-191, miR-525-3p, and miR-767-3p). [score:7]
In contrast, overexpression of miR-21 and miR-191 in cells silenced for TALNEC2, partly rescued the decreased expression of the mesenchymal and stemness markers in the silenced cells, suggesting the decreased expression of these two miRs mediated some of effects observed in the TALNEC2-silenced cells. [score:7]
Rescue experiments overexpressing specific pre-miRs that were downregulated in the silenced cells demonstrated that miR-21 and miR-191, which have been associated with the control of GSC stemness and the EMT process [72, 73], were partly associated with TALNEC2 effects on the mesenchymal transformation and stemness of GSCs. [score:6]
As presented in Figure 6C, overexpression of miR-21 or miR-191 modestly increased the expression of YKL40, fibronectin (FN) and SOX2. [score:5]
The role of miR-21 and miR-191 in TALNEC2 effects was examined by the transduction of TALNEC2 silenced HF2355 GSCS with lentivirus vectors expressing pre-miR-21 and pre-mir-191. [score:3]
We further explored the role of miR-21, miR-191, miR-767 and miR-525 in TALNEC2 effects. [score:1]
[1 to 20 of 7 sentences]
3
[+] score: 37
Other miRNAs from this paper: hsa-mir-191
It is hypothesized that aromatase inhibition through Letrozole treatment reduces oestrogen -mediated binding of the ER to the ERE and therefore reduces miR-191 expression. [score:5]
Assessment of the role of miR-191 in aromatase inhibitor -induced reduction of GBM cell proliferation. [score:3]
Oestrogen is synthesised, catalysed by aromatase, and subsequently binds to the estrogen receptor (ER) alpha/beta subunits which dynamically interact with the estrogen responsive elements (ERE) in the promoter region of miR-191 [39], increasing expression and driving proliferation, migration and chemoresistance in several cancer types [54, 66– 68]. [score:3]
GBM cells (MZ-304) were treated with Letrozole (0.1 μM) and qPCR was carried out to assess the effect of aromatase inhibition on the oestrogen response microRNA, miR-191. [score:3]
As miR-191 is an estrogen-responsive microRNA [39], and its expression has been correlated to the aggressive mesenchymal subtype of GBM [40], it was of interest to evaluate if the treatment with Letrozole (0.1 μM) (Figure 2) alters miR-191 expression in glioma cells. [score:3]
Notably, Letrozole treatment resulted in a 34.46% ± 4.99 reduction in miR-191 expression relative to vehicle -treated controls (A), n = 3, mean ± SEM * p < 0.05). [score:3]
The microRNA-191 (miR-191) has been implicated in several cancer types [35– 38] showing an active role in cell proliferation, migration, chemoresistance and ultimately disease progression. [score:3]
The results showed that Letrozole treatment results in a 34.46% ± 4.99 reduction in miR-191 expression relative to vehicle -treated controls (Figure 6A * p < 0.05). [score:3]
Therefore, qPCR was carried out to assess the effect of aromatase inhibition on levels of miR-191. [score:3]
Figure 6GBM cells (MZ-304) were treated with Letrozole (0.1 μM) and qPCR was carried out to assess the effect of aromatase inhibition on the oestrogen response microRNA, miR-191. [score:3]
In an attempt to understand the mechanism through which Letrozole elicits its anti-tumor effect in GBM cells, the authors evaluated the expression levels of the estrogen-responsive microRNA-191 (miR-191) post-Letrozole treatments. [score:1]
It was found that transient transfection of miR-191 Let -treated MZ-304 cells led to a restoration of ‘normal’ cell proliferation rates, similar to those noted in untreated and DMSO+premiRneg -treated MZ-304 cells (*** p < 0.001, n = 3, mean ± SEM, Two way ANOVA). [score:1]
As shown in Figure 6B, transient transfection of synthetic miR-191 into MZ-304, whose growth rate had been significant reduced by Letrozole treatment, led to a restoration of cell proliferation rates back to basal levels of untreated cells. [score:1]
It was of interest, therefore, to assess if the reduction of GBM cell proliferation after Letrozole-treatment could be reversed by reintroduction of miR-191. [score:1]
After 40 hours, MZ-304 ± Letrozole cells were transiently reverse transfected with control negative (premiR-neg) or synthetic precursor miR-191 (premiR-191) and returned to assess subsequent growth. [score:1]
[1 to 20 of 15 sentences]
4
[+] score: 26
Further, expression of miR-191 was significantly altered across epithelial subtype(p<0.001), with higher levels detected in the Her2 and Basal subtypes. [score:3]
Translation Into - Circulating and Tissue Levels of microRNAsmiR-138, miR-191, and miR-106a were detectable in the circulation of all breast cancer patients and healthy controls included in the study (n = 166). [score:3]
However, as observed with miR-191, miR-106a displayed differential expression across epithelial subtype (ANOVA p<0.05). [score:3]
Although found to be altered on microArray, no significant change in circulating miR-191 during disease progression was observed (p = 0.19, Figure 1B). [score:3]
Expression of miR-138, miR-106a and miR-191 was examined in patient samples. [score:3]
However, when investigated in the blood of mice bearing subcutaneous tumours, miR-191 was significantly downregulated over time (p<0.05, results not shown). [score:2]
It is noteworthy that at a tissue level, miR-191 was previously reported to have lower expression in ER negative tumours compared to ER positive [22]. [score:2]
miR-138, miR-191, and miR-106a were detectable in the circulation of all breast cancer patients and healthy controls included in the study (n = 166). [score:1]
miR-191 levels in (A) Circulation and (B) tissue of Breast Cancer Patients and healthy controls. [score:1]
Indeed, when evaluated in isolation, both miR-191 and miR-106a were significantly down-regulated in patients with basal breast cancer compared to healthy controls (p<0.05, p<0.005 respectively). [score:1]
Both miR-191(in subcutaneous mo del) and miR-106a were found to decrease at a circulating level in the murine mo del, but in patient blood samples there was no significant difference between levels in breast cancer patients and healthy controls. [score:1]
A number of studies have previously reported elevation of miR-191 in tissue of a variety of cancer types including lung [27], hepatocellular [28] and breast [22], [29]. [score:1]
Validation of changes in circulating levels of microRNAs identified using microArray analysis in murine blood samples at week1, week 3 and week 6 following tumour induction (A) Circulating miR-138 (B) Circulating miR-191 (C) Circulating miR-106a. [score:1]
Hu et al [26] previously analysed miR-191 levels in serum of breast cancer patients and healthy controls, and similar to the current findings reported no significant difference, and further suggested use of miR-191 as an endogenous control. [score:1]
[1 to 20 of 14 sentences]
5
[+] score: 16
This polymorphism is located in the 3′ untranslated region (UTR) of the MDM4 gene, and creates a miR-191 target site that can lead to decreased expression of MDM4. [score:7]
This polymorphism, located in the 3′ UTR of MDM4 gene, generates a miR-191 target binding site. [score:3]
The decreased MDM4 expression caused by miR-191 binding might increase the activity of p53 and consequentially modify an MDM4 rs4245739A allele carriers' susceptibility to ovarian cancer and retinoblastoma [39, 40]. [score:3]
As a result, miR-191 selectively binds to mRNA harboring the MDM4 rs4245739C allele to decrease the expression of MDM4 gene at both mRNA and protein levels, but not mRNA with MDM4 rs4245739A allele (wild-type). [score:3]
[1 to 20 of 4 sentences]
6
[+] score: 16
miR-125b, miR-126, miR-10b, miR-10a and miR-191 were underexpressed in cancer samples, whereas miR-26b, miR-607 and miR-135b were overexpressed. [score:5]
In fact, miR-125b, miR-126, miR-10b, miR-10a and miR-191 were underexpressed whereas miR-26b, miR-607 and miR-135b were overexpressed in cancer samples examined, in comparison with the gynecomastia samples. [score:5]
Other miRNAs similarly altered after the enrichment, such as miR-191, miR-454, miR-10a, miR-374a, miR-10b, miR-218, miR-140-3p and miR-126, were downregulated in cancer. [score:4]
To confirm the results of microarray analysis, we performed quantitative real-time PCR analysis on a limited number of samples (19 cancer samples, five gynecomastia samples) using probes corresponding to miR-125b, miR-126, miR-10b, miR-10a, miR-191, miR-26b, miR-607 and miR-135b (Figure 2). [score:1]
analysisTo confirm the results of microarray analysis, we performed quantitative real-time PCR analysis on a limited number of samples (19 cancer samples, five gynecomastia samples) using probes corresponding to miR-125b, miR-126, miR-10b, miR-10a, miR-191, miR-26b, miR-607 and miR-135b (Figure 2). [score:1]
[1 to 20 of 5 sentences]
7
[+] score: 15
In this study we show that at least in vitro, the 3′UTR is a target site of miRNA miR-191, which is up-regulated during scrapie infection. [score:6]
EGR1 is itself a putative target of two miRNAs identified in this study, miR-203 and miR-191. [score:3]
B, Dose dependent reduction in the expression of luciferase activity when HeLa cells are co -transfected with miR-203 and C, co-transfection with miR-191. [score:3]
The siPORT™ NeoFX™ Transfection Agent kit (Ambion) was used to co-transfect HeLa cells with both the reporter vector and mmu-miR-203 or mmu-miR-191 (Ambion). [score:1]
We used a luciferase reporter assay to determine that miR-191, but not miR-203, is a potential regulator of EGR1, Figure 4. 10.1371/journal. [score:1]
We used a luciferase reporter assay to determine that miR-191, but not miR-203, is a potential regulator of EGR1, Figure 4. 10.1371/journal. [score:1]
[1 to 20 of 6 sentences]
8
[+] score: 14
For instance, among Dicer1 -dependent miRNAs, miR-210, miR-204, miR-672, miR-191 and miR-296 are predicted to regulate 13 distinct transcripts whose expression is significantly modified in the corpus or cauda epididymidis of Dicer1 c KO mice. [score:4]
For instance, DC2-derived EVs possess recognition molecules known to be important to intercellular communication, and DC2 cells express some miRNA candidates also found in epididymal principal cells (e. g. miR-210, miR-672, miR-191, miR-204). [score:3]
Ctrl)↑ in Dicer1 c KO mmu-miR-138-5p -26,449 0,00106 mmu-miR-204-3p -4,49045 0,00140 mmu-miR-425-5p -4,24086 0,00380 mmu-miR-672-5p -3,74912 0,00271 mmu-miR-99b-3p -2,71028 0,00362 mmu-miR-191-5p -2,65916 0,00001 mmu-miR-200c-3p -2,57172 0,00340 mmu-miR-671-3p -2,47448 0,00744 mmu-miR-652-3p -2,14466 0,00837↓ in Dicer1 c KO mmu-miR-205-5p 2,07404 0,00226 mmu-miR-7019-5p 2,12703 0,00265 mmu-miR-7653-5p 2,3651 0,00209 mmu-miR-466m-5p 3,2093 0,00585 mmu-miR-669m-5p 3,2093 0,00585We used qRT-PCR to assess the detection level of eight mature miRNA candidates whose expression intensity is changed in the proximal epididymidis of Dicer1 c KO compared with control mice (Fig 1B). [score:2]
Ctrl)↑ in Dicer1 c KO mmu-miR-138-5p -26,449 0,00106 mmu-miR-204-3p -4,49045 0,00140 mmu-miR-425-5p -4,24086 0,00380 mmu-miR-672-5p -3,74912 0,00271 mmu-miR-99b-3p -2,71028 0,00362 mmu-miR-191-5p -2,65916 0,00001 mmu-miR-200c-3p -2,57172 0,00340 mmu-miR-671-3p -2,47448 0,00744 mmu-miR-652-3p -2,14466 0,00837↓ in Dicer1 c KO mmu-miR-205-5p 2,07404 0,00226 mmu-miR-7019-5p 2,12703 0,00265 mmu-miR-7653-5p 2,3651 0,00209 mmu-miR-466m-5p 3,2093 0,00585 mmu-miR-669m-5p 3,2093 0,00585 We used qRT-PCR to assess the detection level of eight mature miRNA candidates whose expression intensity is changed in the proximal epididymidis of Dicer1 c KO compared with control mice (Fig 1B). [score:2]
Conversely, miR-210, miR-672 and miR-191 and miR-204 were present in both cell and EV extracts, suggesting the presence of a selective mechanism of miRNA secretion from principal cells of the epididymis. [score:1]
miR-210, miR-672, miR-191 and miR-204 are secreted from principal cells via extracellular vesicles. [score:1]
miR-210, miR-672, miR-191 and miR-204 are secreted from principal cells via extracellular vesiclesExtracellular vesicles secreted by epithelial cells of the epididymis are heterogeneous in terms of size, nucleic acid content, lipid composition, and marker protein exposure [27, 30, 47, 48]. [score:1]
[1 to 20 of 7 sentences]
9
[+] score: 13
The miRNAs are clustered into five groups: (1: turquoise) The most highly expressed miRNAs in all samples, which are primarily made up of the mGliomiRs and the shared miRNAs; (2, gray) a cluster of miRNAs not expressed in vivo, but with very high expression levels in the cultured MG; (3: black) a “cluster” with miR-21 alone, which is moderately expressed in vivo but increased substantially in vitro; (4: pink) a cluster with miRNAs expressed at low levels in the FAC-sorted MG and which decline further in vitro (including miR-146a, miR-20a+b) and lastly (5: purple) a cluster of miRNAs that are moderately expressed in freshly isolated samples and also decline in vitro (including miR-148a, miR-106/miR-17, and miR-191). [score:13]
[1 to 20 of 1 sentences]
10
[+] score: 12
Other miRNAs from this paper: hsa-mir-191
LOXL2 transduction compared to the EV control downregulated genes known to be involved in TGF-β1 and TNF-α signaling and apoptosis (Fig.   5a- i); these include reactome signaling by TGF-β1 receptor complex, Biocarta TNF-α receptor 1 pathway, reactome activation genes by ATF4, negative regulation of cell proliferation, regulation of angiogenesis regulation of apoptosis, reactome mitogen-activated protein (MAP) kinase nuclear events mediated by MAP kinases, regulation of IkB kinase NF-ĸB cascade, and signaling by miR-191. [score:7]
Gene set enrichment analysis data shown are reactome signaling by transforming growth factor -β1 (TGF-β1) receptor complex (a), Biocarta TNF-α receptor 1 pathway (b), reactome activation genes by ATF4 (c), reactome mitogen-activated protein kinase (MAPK) targets nuclear events mediated by MAPK (d), negative regulation of cell proliferation (e), regulation of angiogenesis (f), regulation of apoptosis (g), regulation of IkB kinase NF-ĸB cascade (h), and signaling by MiR-191 i compared to control (EV). [score:5]
[1 to 20 of 2 sentences]
11
[+] score: 12
We found miR-191-5p, shown previously to regulate IL-6 [44], to be downregulated and this could increase the levels of IL-6, which is consistent with our experimental findings. [score:5]
miR-191-5p, which binds IL-6 [44], is downregulated. [score:4]
In response to OxS, the expression levels of miR-21-5p, miR-1195, miR-181a-5p, and miR-191-5p (as shown in Fig.   8) were changed significantly and this could result in the observed increased levels of STAT3. [score:3]
[1 to 20 of 3 sentences]
12
[+] score: 12
When the expression levels were corrected to that of miR-191, the levels of miR-146a, miR-21a, miR-10a, and miR-10b tended to be higher in UExo of KD dogs than in UExo of HC dogs. [score:3]
This increase was still observed after correction of the expression levels to those of internal control candidates such as miR-26a or miR-191 and closely correlated with changes in renal function indices. [score:3]
When the expression levels were corrected to that of miR-191, miR-21a was positively correlated with age, serum BUN, and Cr, while it was negatively correlated with urinary Cr. [score:3]
Furthermore, the raw levels of miR-26a and miR-191 in UExo correlated with changes of renal function indices such as serum BUN, serum Cr, or urinary Cr. [score:1]
Serum Cr was significantly and negatively correlated with miR-26a, miR-10a, miR-10b, and miR-191 and positively correlated with miR-21a. [score:1]
Urinary Cr was significantly and positively correlated with miR-26a, miR-486, miR-10a, miR-10b, and miR-191. [score:1]
[1 to 20 of 6 sentences]
13
[+] score: 11
1 directly bound with the promoter of miR-191 host gene, promote miR-191 transcription, and post-transcriptionally suppressed C/EBPβ expression during adipogenesis [14]. [score:6]
1 promotes the transcription of miR-191, an miRNA targetting the adipogenic initial transcription factor CCAAT enhancer binding protein β (C/EBPβ), to inhibit adipogenic differentiation in 3T3-L1 preadipocytes [14]. [score:5]
[1 to 20 of 2 sentences]
14
[+] score: 10
a) 6d-8d, b) 8d-12d, c) 12d-15d, d) 15d-21d, e) 21d-P6, f) P48-h6 To further validate these differentially expressed miRNAs identified from the mouse ovary, the expression levels of miR-199a, miR-470, miR-871, miR-34c let-7a, miR-7a, miR-351, miR-191 were further examined in different size follicles (i. e., 100 μm −130 μm, 200 μm -280 μm, 450 μm -550 μm, 500 μm -600 μm) using qRT-PCR assay. [score:4]
E) Expression profile of mmu-mir-191 in sequencing data. [score:3]
e) Expression profile of miR-191 through qRT-PCR. [score:3]
[1 to 20 of 3 sentences]
15
[+] score: 9
For example Peltier and Latham reported expression of tissue miR-191 and miR-103 to be more consistent than commonly used small RNAs and even total RNA [20]. [score:3]
Additionally, miRNA miR-191 and miR-103 have been reported as internal controls for tissue miRNA expression [20]. [score:3]
Serum miR-191 is expressed in all samples, however there is a significant difference (p = 0.001) between all samples (data not shown here). [score:3]
[1 to 20 of 3 sentences]
16
[+] score: 8
Nagpal N. Kulshreshtha R. miR-191: An emerging player in disease biology Front. [score:3]
There is very little specific information on the expression and function of miR-126-5p and miR-191 in skeletal muscle, yet these two miRNAs were identified as two of the more abundant miRNAs in our data. [score:3]
MiR-191 has been reported to regulate important cellular processes such as cell proliferation, differentiation, apoptosis and migration [34]. [score:1]
The top nine most abundant miRNAs shared between the two groups were ssc-miR-10b, ssc-miR-22-3p, ssc-miR-486, ssc-miR-26a, ssc-miR-27b-3p, ssc-miR-191, ssc-miR-378, ssc-126-5p and ssc-miR-181. [score:1]
[1 to 20 of 4 sentences]
17
[+] score: 7
Threshold cycle values for miRNA expression were normalized to the mean expression values of miR-26a and miR-191-5p, which showed lowest variability of expression levels among all samples analyzed. [score:7]
[1 to 20 of 1 sentences]
18
[+] score: 7
Other miRNAs from this paper: hsa-let-7a-1, hsa-let-7a-2, hsa-let-7a-3, hsa-let-7b, hsa-let-7c, hsa-let-7d, hsa-let-7e, hsa-let-7f-1, hsa-let-7f-2, hsa-mir-21, hsa-mir-22, hsa-mir-24-1, hsa-mir-24-2, hsa-mir-25, hsa-mir-26a-1, hsa-mir-92a-1, hsa-mir-92a-2, hsa-mir-99a, mmu-let-7g, mmu-let-7i, mmu-mir-27b, mmu-mir-99a, mmu-mir-140, mmu-mir-10b, mmu-mir-181a-2, mmu-mir-24-1, hsa-mir-192, hsa-mir-148a, hsa-mir-30d, mmu-mir-122, hsa-mir-10b, hsa-mir-181a-2, hsa-mir-181a-1, mmu-let-7d, hsa-let-7g, hsa-let-7i, hsa-mir-27b, hsa-mir-122, hsa-mir-140, hsa-mir-191, hsa-mir-320a, mmu-mir-30d, mmu-mir-148a, mmu-mir-192, mmu-let-7a-1, mmu-let-7a-2, mmu-let-7b, mmu-let-7c-1, mmu-let-7c-2, mmu-let-7e, mmu-let-7f-1, mmu-let-7f-2, mmu-mir-21a, mmu-mir-22, mmu-mir-24-2, mmu-mir-26a-1, mmu-mir-92a-2, mmu-mir-25, mmu-mir-181a-1, mmu-mir-26a-2, mmu-mir-92a-1, hsa-mir-26a-2, hsa-mir-423, hsa-mir-451a, mmu-mir-451a, hsa-mir-486-1, mmu-mir-486a, mmu-mir-423, bta-mir-26a-2, bta-let-7f-2, bta-mir-148a, bta-mir-21, bta-mir-30d, bta-mir-320a-2, bta-mir-99a, bta-mir-181a-2, bta-mir-27b, bta-mir-140, bta-mir-92a-2, bta-let-7d, bta-mir-191, bta-mir-192, bta-mir-22, bta-mir-423, bta-let-7g, bta-mir-10b, bta-mir-24-2, bta-let-7a-1, bta-let-7f-1, bta-mir-122, bta-let-7i, bta-mir-25, bta-let-7a-2, bta-let-7a-3, bta-let-7b, bta-let-7c, bta-let-7e, hsa-mir-1246, bta-mir-24-1, bta-mir-26a-1, bta-mir-451, bta-mir-486, bta-mir-92a-1, bta-mir-181a-1, bta-mir-320a-1, mmu-mir-486b, hsa-mir-451b, bta-mir-1246, mmu-mir-21b, mmu-let-7j, mmu-mir-21c, mmu-mir-451b, mmu-let-7k, hsa-mir-486-2
There were eight microRNAs (bta-miR-27b, bta-miR-191, bta-miR-30d, bta-miR-451, bta-miR-25, bta-miR-140, bta-miR-24-3p, and bta-miR-122), that were upregulated in older animals in the present study, and upregulated in fetal muscle tissue of the study. [score:7]
[1 to 20 of 1 sentences]
19
[+] score: 7
The comparison between control- and MPA -treated cells revealed that 16 miRNAs were significantly modulated by more than two-fold (P < 0.05, Figure 1A), nine miRNAs were upregulated (miR-191*, miR-17*, miR- 470*, miR-451, miR-702, miR-434-3p, miR-493, miR-23a* and miR-485*) and seven were downregulated (miR-378*, miR-376a, miR-224, miR-190b, miR-16, miR-410 and miR-197) (Figure 1B). [score:7]
[1 to 20 of 1 sentences]
20
[+] score: 7
Besides the identification of differential expression of miRNAs, our initial studies identified three reference endogenous miRNAs (miR-103, miR-191, and miR-423-3p). [score:3]
M values and stability factors for GeNorm and NormFinder identify miR-423-3p, miR-191, and miR-103 as endogenous reference miRNAs for mouse experiments. [score:1]
Three reference miRNAs, in addition to the spiked in UniSp2 were used for normalization in the validation experiments (ΔCq = NF − Cq [miRNA]) were NF is the normalization factor and NF = (Cq [miR-103] + Cq [miR-191] + Cq [miR-423-3p] + Cq [UniSp2])/4. [score:1]
Additionally, GeNorm and NormFinder algorithms were run and identified miR-103, miR-191, and miR-423-3p as appropriate reference miRNAs 11. [score:1]
Through pilot large-scale comprehensive profiling studies, we identified three reference miRNAs, miR-109, miR-191, and miR-423-3p with GeNorm and Normfinder that were invariant in the mouse samples and were used as reference miRNAs for those studies. [score:1]
[1 to 20 of 5 sentences]
21
[+] score: 7
We also observed significant inhibition of immunostimulatory ssRNA sensing by select LNA/DNA phosphorothioate AMOs from Classes 3 and 4. Although miRNA -based mechanisms could be at play for LNA/DNA AMOs targeting abundant miRNAs (such as miR-191-5p, miR-16-5p, miR-29a-3p or miR-100-5p), such effects can be ruled out for other AMOs of Class 3 targeting poorly abundant miR-224-5p, miR-331-3p, miR-134-5p or miR-31-5p. [score:7]
[1 to 20 of 1 sentences]
22
[+] score: 7
Two were upregulated (miR-492 and miR-224) and six were downregulated (miR-191, miR-122, miR-192, miR-101, miR-302b, miR-148a) (Figure  1A). [score:7]
[1 to 20 of 1 sentences]
23
[+] score: 7
With these criteria a set of 11 miRNAs (miR-17, miR-33, miR-96, miR-140, miR-181b, miR-183, miR-191, miR-194, miR-199b, miR-341, and miR-1192) were selected that might participate to coordinate with NR2F1 to regulate inner ear gene expression. [score:4]
Of the miRNAs expressed, miR-17 and miR-341 have NR2F1 binding sites within their coding regions, miR-140, miR-191 and miR-199b have NR2F1 binding sites within the proximal promoter region of their loci, and miR-183 and miR-181b have NR2F1 binding sites 8 and 15 base pairs immediately upstream of the transcription start sites, respectively. [score:3]
[1 to 20 of 2 sentences]
24
[+] score: 6
miR-22*, -34c* and -200b* were upregulated against all the injuries whereas expression of miR-191* was repressed by all the injury types. [score:6]
[1 to 20 of 1 sentences]
25
[+] score: 5
Other miRNAs from this paper: mmu-let-7g, mmu-let-7i, mmu-mir-124-3, mmu-mir-140, mmu-mir-141, mmu-mir-152, mmu-mir-182, mmu-mir-183, mmu-mir-199a-1, mmu-mir-200b, mmu-mir-205, mmu-let-7d, mmu-mir-200a, mmu-let-7a-1, mmu-let-7a-2, mmu-let-7b, mmu-let-7c-1, mmu-let-7c-2, mmu-let-7e, mmu-let-7f-1, mmu-let-7f-2, mmu-mir-96, mmu-mir-200c, mmu-mir-214, mmu-mir-199a-2, mmu-mir-199b, mmu-mir-124-1, mmu-mir-124-2, mmu-mir-7a-1, mmu-mir-7a-2, mmu-mir-7b, dre-mir-7b, dre-mir-7a-1, dre-mir-7a-2, dre-mir-182, dre-mir-183, dre-mir-199-1, dre-mir-199-2, dre-mir-199-3, dre-mir-205, dre-mir-214, dre-mir-430a-1, dre-mir-430b-1, dre-mir-430c-1, mmu-mir-429, mmu-mir-449a, dre-mir-429a, dre-let-7a-1, dre-let-7a-2, dre-let-7a-3, dre-let-7a-4, dre-let-7a-5, dre-let-7a-6, dre-let-7b, dre-let-7c-1, dre-let-7c-2, dre-let-7d-1, dre-let-7d-2, dre-let-7e, dre-let-7f, dre-let-7g-1, dre-let-7g-2, dre-let-7h, dre-let-7i, dre-mir-7a-3, dre-mir-96, dre-mir-124-1, dre-mir-124-2, dre-mir-124-3, dre-mir-124-4, dre-mir-124-5, dre-mir-124-6, dre-mir-140, dre-mir-141, dre-mir-152, dre-mir-200a, dre-mir-200b, dre-mir-200c, dre-mir-430c-2, dre-mir-430c-3, dre-mir-430c-4, dre-mir-430c-5, dre-mir-430c-6, dre-mir-430c-7, dre-mir-430c-8, dre-mir-430c-9, dre-mir-430c-10, dre-mir-430c-11, dre-mir-430c-12, dre-mir-430c-13, dre-mir-430c-14, dre-mir-430c-15, dre-mir-430c-16, dre-mir-430c-17, dre-mir-430c-18, dre-mir-430a-2, dre-mir-430a-3, dre-mir-430a-4, dre-mir-430a-5, dre-mir-430a-6, dre-mir-430a-7, dre-mir-430a-8, dre-mir-430a-9, dre-mir-430a-10, dre-mir-430a-11, dre-mir-430a-12, dre-mir-430a-13, dre-mir-430a-14, dre-mir-430a-15, dre-mir-430a-16, dre-mir-430a-17, dre-mir-430a-18, dre-mir-430i-1, dre-mir-430i-2, dre-mir-430i-3, dre-mir-430b-2, dre-mir-430b-3, dre-mir-430b-4, dre-mir-430b-6, dre-mir-430b-7, dre-mir-430b-8, dre-mir-430b-9, dre-mir-430b-10, dre-mir-430b-11, dre-mir-430b-12, dre-mir-430b-13, dre-mir-430b-14, dre-mir-430b-15, dre-mir-430b-16, dre-mir-430b-17, dre-mir-430b-18, dre-mir-430b-5, dre-mir-430b-19, dre-mir-430b-20, dre-let-7j, mmu-mir-449c, mmu-mir-449b, dre-mir-429b, mmu-let-7j, mmu-let-7k, mmu-mir-124b
Finally, 8 of 24 miRNA probes, including miR-200a and miR-200b, as well as miR-96, miR-141, miR-182, miR-183, miR-191, and miR-429, revealed robust expression in the MOE and VNO neuroepithelium, with weaker expression in the adjacent respiratory epithelium (Figure 2A, right column, and Table S3). [score:5]
[1 to 20 of 1 sentences]
26
[+] score: 5
On the other hand, AIRE knockdown results in modulation of different miRNAs (53, 54), with upregulation of miR-20b, miR-191, and miR-411 (54), which is consistent with our observation. [score:5]
[1 to 20 of 1 sentences]
27
[+] score: 5
The specificity of the RT-qPCR assay was further supported by the biodistribution patterns obtained for the tissue-specific miRNAs miR-122 (liver), miR-208a (heart) and miR-124-3p/-5p (brain), and the ubiquitously expressed miRNAs miR-191 and miR-16, using the method (Figure 3a). [score:2]
A t-test was performed on the values obtained for miR-191 quantification. [score:1]
Lack of siRNA RT-qPCR signal could not be ascribed to poor extraction efficiency due to the clear presence of both genomic 18S and miR-191 in this region. [score:1]
The presence of AMO-miR-16 also significantly reduced miR-16 levels in these tissues whereas miR-191 levels (Figure 4f and Supplementary Figure S12) remained unaffected, suggesting that the loss of miR-16 could indeed be the result of AMO binding. [score:1]
[1 to 20 of 4 sentences]
28
[+] score: 4
Among others, such as hsa-miR-191, hsa-miR-200b, hsa-miR-320 and several members of let-7 family we found that hsa-miR-342-3p was regulated at a late stage of disease in both, Scrapie-infected mice and BSE-infected macaques. [score:4]
[1 to 20 of 1 sentences]
29
[+] score: 4
The expression levels of miRNAs were normalized to the geometric mean of miR-103a-3p, miR-191-5p and miR-17a-5p levels as previously described [35]. [score:3]
Data were normalized to ACTB and control for mRNAs or to geometric mean of miR-103a-3p, miR-191-5p and miR-17-5p and control tumors for miRNAs ([*] p value < 0.05; [**] p value < 0.01; [***] p value < 0.001). [score:1]
[1 to 20 of 2 sentences]
30
[+] score: 4
MiR-191-5p was used for normalization since this miRNA had similar expression in both adipose depots in the Small RNA sequencing. [score:3]
miR-191-5p was used for normalization. [score:1]
[1 to 20 of 2 sentences]
31
[+] score: 4
Other miRNAs from this paper: hsa-let-7a-1, hsa-let-7a-2, hsa-let-7a-3, hsa-mir-15a, hsa-mir-18a, hsa-mir-33a, hsa-mir-103a-2, hsa-mir-103a-1, hsa-mir-107, mmu-mir-27b, mmu-mir-126a, mmu-mir-128-1, mmu-mir-140, mmu-mir-146a, mmu-mir-152, mmu-mir-155, hsa-mir-10a, hsa-mir-211, hsa-mir-218-1, hsa-mir-218-2, mmu-mir-297a-1, mmu-mir-297a-2, hsa-mir-27b, hsa-mir-128-1, hsa-mir-140, hsa-mir-152, hsa-mir-191, hsa-mir-126, hsa-mir-146a, mmu-let-7a-1, mmu-let-7a-2, mmu-mir-15a, mmu-mir-18a, mmu-mir-103-1, mmu-mir-103-2, mmu-mir-342, hsa-mir-155, mmu-mir-107, mmu-mir-10a, mmu-mir-218-1, mmu-mir-218-2, mmu-mir-33, mmu-mir-211, hsa-mir-374a, hsa-mir-342, gga-mir-33-1, gga-let-7a-3, gga-mir-155, gga-mir-18a, gga-mir-15a, gga-mir-218-1, gga-mir-103-2, gga-mir-107, gga-mir-128-1, gga-mir-140, gga-let-7a-1, gga-mir-146a, gga-mir-103-1, gga-mir-218-2, gga-mir-126, gga-let-7a-2, gga-mir-27b, mmu-mir-466a, mmu-mir-467a-1, hsa-mir-499a, hsa-mir-545, hsa-mir-593, hsa-mir-600, hsa-mir-33b, gga-mir-499, gga-mir-211, gga-mir-466, mmu-mir-675, mmu-mir-677, mmu-mir-467b, mmu-mir-297b, mmu-mir-499, mmu-mir-717, hsa-mir-675, mmu-mir-297a-3, mmu-mir-297a-4, mmu-mir-297c, mmu-mir-466b-1, mmu-mir-466b-2, mmu-mir-466b-3, mmu-mir-466c-1, mmu-mir-466e, mmu-mir-466f-1, mmu-mir-466f-2, mmu-mir-466f-3, mmu-mir-466g, mmu-mir-466h, mmu-mir-467c, mmu-mir-467d, mmu-mir-466d, hsa-mir-297, mmu-mir-467e, mmu-mir-466l, mmu-mir-466i, mmu-mir-466f-4, mmu-mir-466k, mmu-mir-467f, mmu-mir-466j, mmu-mir-467g, mmu-mir-467h, hsa-mir-664a, hsa-mir-1306, hsa-mir-1307, gga-mir-1306, hsa-mir-103b-1, hsa-mir-103b-2, gga-mir-10a, mmu-mir-1306, mmu-mir-3064, mmu-mir-466m, mmu-mir-466o, mmu-mir-467a-2, mmu-mir-467a-3, mmu-mir-466c-2, mmu-mir-467a-4, mmu-mir-466b-4, mmu-mir-467a-5, mmu-mir-466b-5, mmu-mir-467a-6, mmu-mir-466b-6, mmu-mir-467a-7, mmu-mir-466b-7, mmu-mir-467a-8, mmu-mir-467a-9, mmu-mir-467a-10, mmu-mir-466p, mmu-mir-466n, mmu-mir-466b-8, hsa-mir-466, hsa-mir-3173, hsa-mir-3618, hsa-mir-3064, hsa-mir-499b, mmu-mir-466q, hsa-mir-664b, gga-mir-3064, mmu-mir-126b, gga-mir-33-2, mmu-mir-3618, mmu-mir-466c-3, gga-mir-191
Previous studies revealed that five miRNA genes as well as their host genes (hsa-mir-10a/ HOXB4, hsa-mir-126/ EGFL7, hsa-mir-152/ COPZ2, hsa-mir-191/ DALRD3, and hsa-mir-342/ EVL) were found to be epigenetically downregulated, either by histone modification and/or CpG island hypermethylation in the promoter region in cancer cells [27], [86]– [89] (Table 2 ). [score:4]
[1 to 20 of 1 sentences]
32
[+] score: 4
In addition, miR-106a, miR-146, miR-155, miR-150, miR-17-3p, miR-191, miR-197, miR-192, miR-21, miR-203, miR-205, miR-210, miR-212, and miR-214 have been reported to be up-regulated in lung cancer [12]. [score:4]
[1 to 20 of 1 sentences]
33
[+] score: 3
Hsa-miR-15a-5p, hsa-miR-16-5p, hsa-miR-30c, hsa-miR-451a, hsa-miR-191-5p, hsa-miR-486-5p and hsa-miR-335-3p for instance have been described to be aberrantly expressed in metastatic neuroblastoma tumors 23. [score:3]
[1 to 20 of 1 sentences]
34
[+] score: 3
Other miRNAs from this paper: hsa-let-7a-1, hsa-let-7a-2, hsa-let-7a-3, hsa-let-7b, hsa-let-7c, hsa-let-7d, hsa-let-7e, hsa-let-7f-1, hsa-let-7f-2, hsa-mir-17, hsa-mir-18a, hsa-mir-19a, hsa-mir-19b-1, hsa-mir-19b-2, hsa-mir-20a, hsa-mir-21, hsa-mir-24-1, hsa-mir-24-2, hsa-mir-27a, hsa-mir-29a, hsa-mir-30a, hsa-mir-92a-1, hsa-mir-92a-2, hsa-mir-93, hsa-mir-100, hsa-mir-29b-1, hsa-mir-29b-2, hsa-mir-103a-2, hsa-mir-103a-1, hsa-mir-107, mmu-let-7g, mmu-let-7i, mmu-mir-1a-1, mmu-mir-23b, mmu-mir-27b, mmu-mir-29b-1, mmu-mir-30a, mmu-mir-30b, mmu-mir-125a, mmu-mir-9-2, mmu-mir-133a-1, mmu-mir-136, mmu-mir-138-2, mmu-mir-181a-2, mmu-mir-24-1, hsa-mir-196a-1, hsa-mir-148a, hsa-mir-30c-2, hsa-mir-30d, mmu-mir-122, mmu-mir-143, mmu-mir-30e, hsa-mir-34a, hsa-mir-181a-2, hsa-mir-196a-2, hsa-mir-181a-1, mmu-mir-296, mmu-mir-298, mmu-mir-34c, mmu-let-7d, mmu-mir-130b, hsa-let-7g, hsa-let-7i, hsa-mir-1-2, hsa-mir-23b, hsa-mir-27b, hsa-mir-30b, hsa-mir-122, hsa-mir-133a-1, hsa-mir-133a-2, hsa-mir-138-2, hsa-mir-143, hsa-mir-191, hsa-mir-9-1, hsa-mir-9-2, hsa-mir-9-3, hsa-mir-125a, hsa-mir-136, hsa-mir-138-1, mmu-mir-19b-2, mmu-mir-30c-1, mmu-mir-30c-2, mmu-mir-30d, mmu-mir-148a, mmu-mir-196a-1, mmu-mir-196a-2, mmu-let-7a-1, mmu-let-7a-2, mmu-let-7b, mmu-let-7c-1, mmu-let-7c-2, mmu-let-7e, mmu-let-7f-1, mmu-let-7f-2, mmu-mir-18a, mmu-mir-20a, mmu-mir-21a, mmu-mir-24-2, mmu-mir-29a, mmu-mir-29c, mmu-mir-27a, mmu-mir-92a-2, mmu-mir-93, mmu-mir-34a, mmu-mir-103-1, mmu-mir-103-2, mmu-mir-330, mmu-mir-346, hsa-mir-1-1, mmu-mir-1a-2, mmu-mir-107, mmu-mir-17, mmu-mir-19a, mmu-mir-100, mmu-mir-181a-1, mmu-mir-29b-2, mmu-mir-19b-1, mmu-mir-92a-1, mmu-mir-9-1, mmu-mir-9-3, mmu-mir-138-1, hsa-mir-29c, hsa-mir-30c-1, hsa-mir-34c, hsa-mir-296, hsa-mir-130b, hsa-mir-30e, hsa-mir-375, hsa-mir-381, mmu-mir-375, mmu-mir-381, hsa-mir-330, mmu-mir-133a-2, hsa-mir-346, hsa-mir-196b, mmu-mir-196b, hsa-mir-18b, hsa-mir-20b, hsa-mir-146b, hsa-mir-519d, hsa-mir-501, hsa-mir-503, mmu-mir-20b, mmu-mir-503, hsa-mir-92b, mmu-mir-146b, mmu-mir-669c, mmu-mir-501, mmu-mir-718, mmu-mir-18b, mmu-mir-92b, hsa-mir-298, mmu-mir-1b, hsa-mir-103b-1, hsa-mir-103b-2, hsa-mir-718, mmu-mir-21b, mmu-let-7j, mmu-mir-21c, mmu-mir-30f, mmu-let-7k, mmu-mir-9b-2, mmu-mir-9b-1, mmu-mir-9b-3
Our results are also mostly in agreement with those of Esau et al. [25] who identified a similar expression pattern regarding miR-130b, miR-30c, miR-30a*, miR-191, miR-30d, miR-196, miR-30b, miR-19b, miR-92, miR-138 and miR-100 during differentiation of cultured human adipocytes. [score:3]
[1 to 20 of 1 sentences]
35
[+] score: 3
The results of qPCR analyses carried out by testing the RNA samples of mice from 6 experimental groups (Sham, Aspirin, Naproxen, ECS, ECS + Aspirin, and ECS + Naproxen) for miR- 146a, miR-191, miR-199b, and miR-223 are shown in Figure 5. Although the differences among groups were more attenuated, qPCR analyses confirmed the microarray data. [score:1]
In particular, some of the miRNAs modulated by aspirin in mice protected against the formation of microadenomas (miR-16, miR-133, miR-137, and miR-191) were the same that had been found to be modulated by the same NSAID in A/J mice aged 10 weeks. [score:1]
Microarray data were validated by real time-qPCR for miR- 146a, miR-191, miR-199b, and miR-223 as previously described [27]. [score:1]
[1 to 20 of 3 sentences]
36
[+] score: 3
A number of further targets were identified through miRNA/protein correlations, such as the mir-200 family (miR-200a, miR-200b and miR-200c), miR-191, miR-195, miR-301, and miR-322 (Figure 4D). [score:3]
[1 to 20 of 1 sentences]
37
[+] score: 3
Another eight constitutive miRNAs (let-7d-5p, let-7f-5p, miR-23a-3p, miR-26a-5p, miR-30a-3p, miR-3od-5p, miR-191-5p, and miR-192-5p), which showed homogeneous expression in the microarray analysis were used for normalization. [score:3]
[1 to 20 of 1 sentences]
38
[+] score: 3
Other miRNAs from this paper: mmu-mir-30a, mmu-mir-30b, mmu-mir-141, mmu-mir-151, mmu-mir-10b, mmu-mir-143, mmu-mir-30e, mmu-mir-34c, mmu-mir-34b, mmu-mir-30c-1, mmu-mir-30c-2, mmu-mir-30d, mmu-mir-21a, mmu-mir-10a, mmu-mir-139, mmu-mir-375, mmu-mir-196b, mmu-mir-465a, mmu-mir-466a, mmu-mir-467a-1, mmu-mir-669a-1, mmu-mir-669b, mmu-mir-669a-2, mmu-mir-669a-3, mmu-mir-467b, mmu-mir-669c, mmu-mir-465b-1, mmu-mir-465b-2, mmu-mir-465c-1, mmu-mir-465c-2, mmu-mir-466b-1, mmu-mir-466b-2, mmu-mir-466b-3, mmu-mir-466c-1, mmu-mir-466e, mmu-mir-466f-1, mmu-mir-466f-2, mmu-mir-466f-3, mmu-mir-466g, mmu-mir-466h, mmu-mir-467c, mmu-mir-467d, mmu-mir-466d, mmu-mir-208b, mmu-mir-467e, mmu-mir-466l, mmu-mir-669k, mmu-mir-669g, mmu-mir-669d, mmu-mir-466i, mmu-mir-669j, mmu-mir-669f, mmu-mir-669i, mmu-mir-669h, mmu-mir-466f-4, mmu-mir-466k, mmu-mir-467f, mmu-mir-466j, mmu-mir-669e, mmu-mir-467g, mmu-mir-467h, mmu-mir-669l, mmu-mir-669m-1, mmu-mir-669m-2, mmu-mir-669o, mmu-mir-669n, mmu-mir-466m, mmu-mir-669d-2, mmu-mir-466o, mmu-mir-467a-2, mmu-mir-669a-4, mmu-mir-669a-5, mmu-mir-467a-3, mmu-mir-466c-2, mmu-mir-669a-6, mmu-mir-467a-4, mmu-mir-466b-4, mmu-mir-669a-7, mmu-mir-467a-5, mmu-mir-466b-5, mmu-mir-669p-1, mmu-mir-467a-6, mmu-mir-669a-8, mmu-mir-466b-6, mmu-mir-669a-9, mmu-mir-467a-7, mmu-mir-466b-7, mmu-mir-669p-2, mmu-mir-467a-8, mmu-mir-669a-10, mmu-mir-467a-9, mmu-mir-669a-11, mmu-mir-467a-10, mmu-mir-669a-12, mmu-mir-466p, mmu-mir-466n, mmu-mir-466b-8, mmu-mir-466q, mmu-mir-6240, mmu-mir-30f, mmu-mir-465d, mmu-mir-466c-3
The ability of sperm-epididymosome interaction to facilitate transfer of miRNA cargo to sperm was directly assessed by RT-qPCR amplification of candidate miRNAs (miR-191, miR-375, miR-467a, miR-467d, and miR-467e) from sperm that were incubated in either media alone (sperm only) or epididymosomes (sperm + ES). [score:2]
Five miRNAs (miR-191, miR-375, miR-467a, miR-467d, miR-467e) were selected for inclusion in this analysis based on their high abundance in caput epididymosomes. [score:1]
[1 to 20 of 2 sentences]
39
[+] score: 3
After normalizing the expression levels with the corresponding geometric mean value of the reference genes U6 snRNA, mmu-miR-191, mmu-miR-423-5p, mmu-miR-361 and mmu-miR-103, the samples were checked for outliers to be excluded. [score:3]
[1 to 20 of 1 sentences]
40
[+] score: 3
Similar Treg therapies are being used to treat diabetes (7) and could be used to restore normal expression of miR-342, miR-191, and miR-510 in Treg from diabetes patients (68). [score:3]
[1 to 20 of 1 sentences]
41
[+] score: 3
*Additional microRNAs that were differentially expressed between β and Hpi1- rGBC include hsa-miR-191-5p,-26a-1-3p,-182-5p,-20a-3p,-486-3p,-200c-3p. [score:3]
[1 to 20 of 1 sentences]
42
[+] score: 3
MicroRNAs targeting MDM4: miR-191, miR-10a, miR-885-3p, miR-34a, miR-661 [reviewed in Ref. [score:3]
[1 to 20 of 1 sentences]
43
[+] score: 3
Many miRNAs that we identified as being differentially expressed in granulopoiesis were not previously implicated in this process including miR-19a, miR-19b miR-24, miR-26a, miR-26b, miR-93, miR-106b, miR-191, miR-139-5p, miR-140 and miR-195 (Figures 2A and 3, Additional file 1). [score:3]
[1 to 20 of 1 sentences]
44
[+] score: 3
In the last decades, rs4245739 A > C was wi dely studied, which was found to create a functional target site for hsa-miR-191 and hsa-miR-887. [score:3]
[1 to 20 of 1 sentences]
45
[+] score: 2
miR-1, miR-10b, miR-155, and miR-191 are novel regulators of BDNF. [score:2]
[1 to 20 of 1 sentences]
46
[+] score: 2
miRNA expression profile was assessed using Taqman miRNA assays (Applied biosystems) for hsa/mmu-miR-449a and b, hsa/mmu-miR-34a, b and c and rnu44 or hsa/mmu-miR-191. [score:2]
[1 to 20 of 1 sentences]
47
[+] score: 2
The miRNA levels of endogenous mature miR-125 and miR-504 were analyzed and normalized with miR-191. [score:1]
The results of the genes and miRNA were normalized to the HPRT [50] and miR191 [49], respectively. [score:1]
[1 to 20 of 2 sentences]
48
[+] score: 2
Other miRNAs from this paper: hsa-let-7a-1, hsa-let-7a-2, hsa-let-7a-3, hsa-let-7b, hsa-let-7c, hsa-let-7d, hsa-let-7e, hsa-let-7f-1, hsa-let-7f-2, hsa-mir-19a, hsa-mir-20a, hsa-mir-23a, hsa-mir-24-1, hsa-mir-24-2, hsa-mir-25, hsa-mir-26a-1, hsa-mir-30a, hsa-mir-33a, hsa-mir-96, hsa-mir-98, hsa-mir-103a-2, hsa-mir-103a-1, mmu-let-7g, mmu-let-7i, mmu-mir-23b, mmu-mir-30a, mmu-mir-30b, mmu-mir-99b, mmu-mir-125a, mmu-mir-125b-2, mmu-mir-9-2, mmu-mir-133a-1, mmu-mir-146a, mmu-mir-155, mmu-mir-182, mmu-mir-183, mmu-mir-24-1, mmu-mir-199a-1, hsa-mir-199a-1, mmu-mir-200b, hsa-mir-30c-2, hsa-mir-30d, mmu-mir-30e, hsa-mir-181b-1, hsa-mir-182, hsa-mir-183, hsa-mir-199a-2, hsa-mir-199b, hsa-mir-221, hsa-mir-223, hsa-mir-200b, mmu-mir-299a, mmu-let-7d, hsa-let-7g, hsa-let-7i, hsa-mir-23b, hsa-mir-30b, hsa-mir-125b-1, hsa-mir-133a-1, hsa-mir-133a-2, hsa-mir-191, hsa-mir-9-1, hsa-mir-9-2, hsa-mir-9-3, hsa-mir-125a, hsa-mir-125b-2, hsa-mir-146a, mmu-mir-30c-1, mmu-mir-30c-2, mmu-mir-30d, mmu-let-7a-1, mmu-let-7a-2, mmu-let-7b, mmu-let-7c-1, mmu-let-7c-2, mmu-let-7e, mmu-let-7f-1, mmu-let-7f-2, mmu-mir-20a, mmu-mir-21a, mmu-mir-23a, mmu-mir-24-2, mmu-mir-26a-1, mmu-mir-96, mmu-mir-98, mmu-mir-103-1, mmu-mir-103-2, mmu-mir-148b, mmu-mir-351, hsa-mir-200c, hsa-mir-155, hsa-mir-181b-2, mmu-mir-19a, mmu-mir-25, mmu-mir-200c, mmu-mir-223, mmu-mir-26a-2, mmu-mir-221, mmu-mir-199a-2, mmu-mir-199b, mmu-mir-9-1, mmu-mir-9-3, mmu-mir-181b-1, mmu-mir-125b-1, hsa-mir-30c-1, hsa-mir-299, hsa-mir-99b, hsa-mir-30e, hsa-mir-26a-2, hsa-mir-361, mmu-mir-361, hsa-mir-365a, mmu-mir-365-1, hsa-mir-365b, hsa-mir-375, mmu-mir-375, hsa-mir-148b, mmu-mir-133a-2, mmu-mir-133b, hsa-mir-133b, mmu-mir-181b-2, mmu-mir-433, hsa-mir-429, mmu-mir-429, mmu-mir-365-2, hsa-mir-433, hsa-mir-490, hsa-mir-193b, hsa-mir-92b, mmu-mir-490, mmu-mir-193b, mmu-mir-92b, hsa-mir-103b-1, hsa-mir-103b-2, mmu-mir-299b, mmu-mir-133c, mmu-let-7j, mmu-mir-30f, mmu-let-7k, mmu-mir-9b-2, mmu-mir-9b-1, mmu-mir-9b-3
Upon HDI treatment, the average RPM of all the miRNAs were slightly increased to 32.19 (13.63, if we exclude the three most abundant miRNAs miR-21a, miR-191, and miR-146a) (R [2] = 0.9811, p = 0.5134). [score:1]
In stimulated B cells, the average RPM of 520 miRNAs analyzed was 26.9 (10.75, if one excludes the three most abundant miRNAs miR-21a, miR-191, and miR-146a). [score:1]
[1 to 20 of 2 sentences]
49
[+] score: 2
Data represent the relative gene expression for each patient calculated with qBase + software using miR-125a-5p and miR-191-5p as reference microRNAs. [score:1]
Each sample was then run in triplicates for miR-184 as well as for two reference miRNAs (miR-125a-5p and miR-191-5p). [score:1]
[1 to 20 of 2 sentences]
50
[+] score: 2
Among them, there were 52 mature miRNAs with sequence reads ≥ 400 (Additional file 1: Table S4) and 10 mature miRNAs (mir-10b-5p, mir-133a-1-3p, mir-133a-2-3p, mir-191-5p, mir-22-3p, mir-25-3p, mir-3107-5p, mir-486-5p, mir-92a-1-3p, mir-92a-2-3p) with sequence reads ≧ 4000 in at least 1 of the 12 twelve libraries (Additional file 1: Table S5). [score:1]
Small RNA deep sequencing and qPCR results of five selected miRNAs (mir-133a-1-3p, mir-127-3p, mir-25-3p, mir-191-5p, and mir-215-5p) were generally in agreement, with a Pearson correlation value of 0.921 (Additional file 2). [score:1]
[1 to 20 of 2 sentences]
51
[+] score: 1
Estrogen mediated the activation of miR-191/425 cluster in ER positive BC cells [51]. [score:1]
[1 to 20 of 1 sentences]
52
[+] score: 1
miR-146a levels were normalized to hsa-miR-191 (Applied Biosystems), which served as an endogenous control. [score:1]
[1 to 20 of 1 sentences]
53
[+] score: 1
Other miRNAs from this paper: mmu-mir-218-1, mmu-mir-218-2
miR-191 was used as an internal control. [score:1]
[1 to 20 of 1 sentences]
54
[+] score: 1
Other miRNAs from this paper: mmu-mir-155
ΔCt values were normalized using the geometric mean of the three most stable endogenous reference genes, U6 snRNA, 5S rRNA and hsa-miR-191. [score:1]
[1 to 20 of 1 sentences]
55
[+] score: 1
Other miRNAs from this paper: mmu-mir-10b
Reference gene was miR191. [score:1]
[1 to 20 of 1 sentences]
56
[+] score: 1
Quantitative RT-PCR analysis of four microRNAs (hsa-miR-103a, hsa-miR-182, hsa-miR-191 and hsa-miR-223), comprising both their mature and precursor forms, in the ADF (A), OVCAR3 (B), PC3 (C) and primary HDFa (D) cell lines, treated with either SI113 (12.5 μM for 72 h) or DMSO. [score:1]
[1 to 20 of 1 sentences]
57
[+] score: 1
Other miRNAs from this paper: hsa-let-7a-1, hsa-let-7a-2, hsa-let-7a-3, hsa-let-7b, hsa-let-7c, hsa-let-7d, hsa-let-7e, hsa-let-7f-1, hsa-let-7f-2, hsa-mir-15a, hsa-mir-16-1, hsa-mir-17, hsa-mir-20a, hsa-mir-23a, hsa-mir-24-1, hsa-mir-24-2, hsa-mir-26a-1, hsa-mir-26b, hsa-mir-29a, hsa-mir-30a, hsa-mir-93, hsa-mir-101-1, hsa-mir-29b-1, hsa-mir-29b-2, hsa-mir-107, hsa-mir-16-2, mmu-let-7g, mmu-let-7i, mmu-mir-15b, mmu-mir-23b, mmu-mir-29b-1, mmu-mir-30a, mmu-mir-30b, mmu-mir-101a, mmu-mir-124-3, mmu-mir-125a, mmu-mir-130a, mmu-mir-9-2, mmu-mir-135a-1, mmu-mir-136, mmu-mir-138-2, mmu-mir-140, mmu-mir-144, mmu-mir-145a, mmu-mir-146a, mmu-mir-149, mmu-mir-152, mmu-mir-10b, mmu-mir-181a-2, mmu-mir-182, mmu-mir-183, mmu-mir-185, mmu-mir-24-1, mmu-mir-193a, mmu-mir-195a, mmu-mir-200b, mmu-mir-204, hsa-mir-30c-2, hsa-mir-30d, mmu-mir-30e, hsa-mir-7-1, hsa-mir-7-2, hsa-mir-7-3, hsa-mir-10a, hsa-mir-10b, hsa-mir-34a, hsa-mir-181a-2, hsa-mir-181b-1, hsa-mir-181c, hsa-mir-182, hsa-mir-183, hsa-mir-204, hsa-mir-181a-1, hsa-mir-221, hsa-mir-222, hsa-mir-200b, mmu-mir-301a, mmu-mir-34c, mmu-mir-34b, mmu-let-7d, mmu-mir-130b, hsa-let-7g, hsa-let-7i, hsa-mir-15b, hsa-mir-23b, hsa-mir-30b, hsa-mir-124-1, hsa-mir-124-2, hsa-mir-124-3, hsa-mir-130a, hsa-mir-135a-1, hsa-mir-135a-2, hsa-mir-138-2, hsa-mir-140, hsa-mir-144, hsa-mir-145, hsa-mir-152, hsa-mir-191, hsa-mir-9-1, hsa-mir-9-2, hsa-mir-9-3, hsa-mir-125a, hsa-mir-136, hsa-mir-138-1, hsa-mir-146a, hsa-mir-149, hsa-mir-185, hsa-mir-193a, hsa-mir-195, hsa-mir-320a, mmu-mir-30c-1, mmu-mir-30c-2, mmu-mir-30d, mmu-let-7a-1, mmu-let-7a-2, mmu-let-7b, mmu-let-7c-1, mmu-let-7c-2, mmu-let-7e, mmu-let-7f-1, mmu-let-7f-2, mmu-mir-15a, mmu-mir-16-1, mmu-mir-16-2, mmu-mir-20a, mmu-mir-23a, mmu-mir-24-2, mmu-mir-26a-1, mmu-mir-26b, mmu-mir-29a, mmu-mir-29c, mmu-mir-93, mmu-mir-34a, mmu-mir-330, mmu-mir-339, mmu-mir-340, mmu-mir-135b, mmu-mir-101b, hsa-mir-200c, hsa-mir-181b-2, mmu-mir-107, mmu-mir-10a, mmu-mir-17, mmu-mir-200c, mmu-mir-181a-1, mmu-mir-320, mmu-mir-26a-2, mmu-mir-221, mmu-mir-222, mmu-mir-29b-2, mmu-mir-135a-2, mmu-mir-124-1, mmu-mir-124-2, mmu-mir-9-1, mmu-mir-9-3, mmu-mir-138-1, mmu-mir-181b-1, mmu-mir-181c, mmu-mir-7a-1, mmu-mir-7a-2, mmu-mir-7b, hsa-mir-29c, hsa-mir-30c-1, hsa-mir-101-2, hsa-mir-34b, hsa-mir-34c, hsa-mir-301a, hsa-mir-130b, hsa-mir-30e, hsa-mir-26a-2, hsa-mir-361, mmu-mir-361, hsa-mir-376a-1, mmu-mir-376a, hsa-mir-340, hsa-mir-330, hsa-mir-135b, hsa-mir-339, hsa-mir-335, mmu-mir-335, mmu-mir-181b-2, mmu-mir-376b, mmu-mir-434, mmu-mir-467a-1, hsa-mir-376b, hsa-mir-485, hsa-mir-146b, hsa-mir-193b, hsa-mir-181d, mmu-mir-485, mmu-mir-541, hsa-mir-376a-2, hsa-mir-320b-1, hsa-mir-320c-1, hsa-mir-320b-2, mmu-mir-301b, mmu-mir-674, mmu-mir-146b, mmu-mir-467b, mmu-mir-669c, mmu-mir-708, mmu-mir-676, mmu-mir-181d, mmu-mir-193b, mmu-mir-467c, mmu-mir-467d, hsa-mir-541, hsa-mir-708, hsa-mir-301b, mmu-mir-467e, mmu-mir-467f, mmu-mir-467g, mmu-mir-467h, hsa-mir-320d-1, hsa-mir-320c-2, hsa-mir-320d-2, mmu-mir-467a-2, mmu-mir-467a-3, mmu-mir-467a-4, mmu-mir-467a-5, mmu-mir-467a-6, mmu-mir-467a-7, mmu-mir-467a-8, mmu-mir-467a-9, mmu-mir-467a-10, hsa-mir-320e, hsa-mir-676, mmu-mir-101c, mmu-mir-195b, mmu-mir-145b, mmu-let-7j, mmu-mir-130c, mmu-mir-30f, mmu-let-7k, mmu-mir-9b-2, mmu-mir-124b, mmu-mir-9b-1, mmu-mir-9b-3
99E-0249mmu-miR-185-5pmir-1850.198.912.60E-033.38E-0241mmu-miR-191-5pmir-1910.199.711.25E-031.94E-0228mmu-miR-193-3pmir-1930.256.553.70E-048.12E-0329mmu-miR-1952mir-19520.219.183.70E-048.12E-0372mmu-miR-1961mir-19610.196.581.03E-029.11E-0234mmu-miR-204-5pmir-2040.317.746.87E-041.29E-0226mmu-miR-222-3pmir-2210.2310.222.37E-045.81E-0335mmu-miR-221-3pmir-2210.259.098.47E-041. [score:1]
[1 to 20 of 1 sentences]
58
[+] score: 1
miRNA levels were normalized against the average of five reference miRNAs (miR-423-5p, miR-103a-3p, miR-191-5p, miR-425-5p, and miR-93), which were used as internal controls in plasma samples. [score:1]
[1 to 20 of 1 sentences]
59
[+] score: 1
miR-191 and miR-135 are required for long-lasting spine remo delling associated with synaptic long-term depression. [score:1]
[1 to 20 of 1 sentences]
60
[+] score: 1
Briefly, results were normalized using the ΔΔCp method with multiple reference genes (U6, RNU1A1, miR-191-5p and miR-423-5p) [65]. [score:1]
[1 to 20 of 1 sentences]
61
[+] score: 1
For example, let-7d induces cellular apoptosis 43; mir-126 modulates the repair of damaged endothelium 44; and circulating mir-191 is increased in smokers 26 and individuals with pulmonary hypertension 45. [score:1]
[1 to 20 of 1 sentences]