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17 publications mentioning rno-mir-205

Open access articles that are associated with the species Rattus norvegicus and mention the gene name mir-205. Click the [+] symbols to view sentences that include the gene name, or the word cloud on the right for a summary.

[+] score: 103
The mechanism of HPM in treating CD may be through upregulating the expression of miR-147 and/or miR-205 that are abnormally downregulated in CD rats' colons to further regulate some of their target genes, thereby indirectly inhibiting the inflammatory signal pathways mediated by TLR, NF- κB, and so forth and decreasing the production of downstream inflammatory cytokines such as TNF- α and IL-1 β [19], so as to alleviate intestinal inflammation in CD. [score:15]
In breast cancer, prostate cancer, and other tumor diseases, miR-205 may inhibit tumor cell proliferation, invasion, and tumor growth by reversing EMT and downregulating the expression of ZEB1/2 [51– 53], and it may also increase the sensitivity of tumor cells to chemotherapeutic drugs [54], thereby playing a role in tumor suppression. [score:12]
As shown in Figure 7, our initial miRNA microarray profiling identified 6 CD -associated miRNAs that were regulated by HPM, of which 3 miRNAs, miR-300-5p, miR-664-2 [*], and miR-883 [*], were increased after mo deling but downregulated after HPM, and the other 3 miRNAs, miR-147, miR-205, and let-7i [*], were inhibited after mo deling while being upregulated after HPM. [score:10]
HPM could significantly upregulate the expression of miR-147 and miR-205 in CD rats' colons, initially and indirectly affirming that HPM should be potential in preventing pathogenesis of tumor diseases. [score:9]
As a tumor-promoting factor, miR-205 may promote the onset, development, and metastasis of tumors and increase tolerance of tumor cells to radiotherapy and chemotherapy by targeting and inhibiting tumor-suppressing genes such as PTEN in tumors like non-small cell lung cancer and endometrial cancer, resulting in a decreased survival rate in the patients [55, 56]. [score:8]
In our study, the expression of miR-147 and miR-205 was significantly decreased in colons of experimental CD rats, indicating that their downregulation was closely related to CD pathogenesis, and might increase the possibility of experimental CD rats in developing colon cancer and other tumor diseases. [score:8]
Finally we found that downregulated miR-147 and miR-205 in CD rats' colons were both significantly upregulated by HPM, with 2.64- and 3.72-fold increase, respectively. [score:7]
In summary, our research has found that HPM at Tianshu and Qihai of experimental CD rats can not only significantly improve the histopathological damage of CD rats' colons, but also target and upregulate miR-147 and miR-205 in CD rats' colons. [score:6]
The target genes of miR-147 and miR-205 were predicted using online query facility TargetScan 6.2. [score:5]
The potential target genes of miR-147 are BDNF, ZNF148, ZNF518B, and so forth, and miR-205 can target hundreds of genes, like LRP1, LRRK2, SerpinB2, SMAD4, ErbB4, MARCKS, ADAMTS9, MMD, IL-1R1, and so forth. [score:5]
The expression of miR-205 also showed the similar trends in murine and human melanoma cells after curcumin treatment [57]. [score:3]
Prediction of miR-147 and miR-205 Target Genes in Rats. [score:3]
To further verify the results from miRNA microarray analysis, 3 differentially expressed miRNAs (miR-300-5p, miR-147, and miR-205) were chosen to be tested by qRT-PCR in additional frozen colons of all groups. [score:3]
miR-205 can not only suppress tumors, but also play a role in promoting tumor progression. [score:3]
As demonstrated in Figure 8, miRNA qRT-PCR confirmed that miR-147 and miR-205 were significantly downregulated in the MC group compared with the NC group (P < 0.01, P < 0.05, resp. [score:3]
org/), only miR-300-5p, miR-147, and miR-205 were chosen to be further validated by miRNA qRT-PCR. [score:1]
For now, most researches related to miR-147 and miR-205 are associated with cancers. [score:1]
Moreover, the sequences of miR-147 and miR-205 are also highly homogenous in rats and human (http://www. [score:1]
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[+] score: 78
Other miRNAs from this paper: rno-mir-21, rno-mir-200c
In the experiment that we performed to identify the minimal ischemic time that would induce the expression of these 3 miRNAs, upregulation of miR-21 and miR-200c was noted after 4 h of reperfusion following 1 h and 2 h, but not 30 min of ischemia; in addition, upregulation of miR-205 was noted after 4 h of reperfusion following 2 h, but not 30 min or 1 h of ischemia (Figure 2). [score:9]
Because bioinformatic analysis has indicated that miRNAs frequently interact with transcription factors in feedback and feedforward loops to regulate their target genes [43, 44]; therefore, further experiments are required to elucidate the function and role of these potential target genes and the upregulated miR-21, as well as miR-200c and miR-205, in ischemic injury. [score:9]
This study has profiled an increased expression of miR-21, miR-200c, and miR-205 in the gracilis muscle following ischemic injury and identified four potential target genes (Nqo1, Pdpn, CXCL3, and Rad23b) of the miR-21 by using different prediction algorithms and monitoring the expression of miRNA and mRNA at different time point on a genome-wide basis. [score:7]
Our data also showed that miR-200c and miR-205 were actively regulated after ischemia but their expression pattern changed after reperfusion, indicating their temporal expression during ischemic injury. [score:6]
Ischemia for only 1 h was sufficient to induce the expression of miR-21 and miR-200c during the reperfusion stage; and 2 h of ischemia were required to induce the expression of miR-205. [score:5]
Those upregulated miRNAs (miR-21, miR-200c, and miR-205) that were identified from the miRNA array were quantified by real-time RT-PCR with the Applied Biosystems 7500 (Applied Biosystems, USA). [score:4]
The miR-200c and miR-205 were not upregulated at all 4 indicated times. [score:4]
A 6.4-fold upregulation of miR-205 was detected after 4 h of ischemia. [score:4]
In this study, we demonstrated that 3 miRNAs (miR-21, miR-200c, and miR-205) were significantly upregulated in a different pattern in the gracilis muscles following ischemic injury. [score:4]
Unexpectedly, we noted the 3.6-fold upregulation of miR-205 7 d later. [score:4]
Real-time RT-PCR demonstrated that, with 2-fold increase after 4 h of ischemia, a maximum 24-fold increase at 7 d, and a 7.5-fold increase at 14 d after reperfusion, only the miR-21, but not the miR-200c or miR-205 was upregulated throughout the experimental time. [score:4]
Figure 1 Expression of miR-21, miR-200c, and miR-205 detected with real-time RT-PCR in the gracilis muscles following 4 h of ischemia and reperfusion for indicated times. [score:3]
In addition, with a yet to be determined mechanism, we noted a significant re -expression of miR-205 at 7 and 14 d after the injury. [score:3]
Figure 2 Expression of miR-21, miR-200c, and miR-205 detected with real-time RT-PCR in the gracilis muscles following indicated ischemic times (30 min, 1 h, and 2 h) and reperfusion for 4 h. Bars represent means ± standard deviation of 5 independent experiments; *, P < 0.05 vs. [score:3]
Three miRNAs (miR-21, miR-200c, and miR-205) of 350 tested rat miRNAs were found to have an increased expression in the miRNA array. [score:3]
In the investigation of the differentially expressed miRNAs from the miRNA array experiments, there were only 3 miRNAs (miR-21, miR-200c, and miR-205) that showed an increased expression in the gracilis muscles after 4 h of ischemia and 4 h of reperfusion. [score:3]
No significant difference in the expression of miR-205 was found at 8 h, 1 d, and 3 d after ischemic injury. [score:3]
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[+] score: 20
Other miRNAs from this paper: hsa-mir-16-1, hsa-mir-17, hsa-mir-20a, hsa-mir-21, hsa-mir-23a, hsa-mir-100, hsa-mir-103a-2, hsa-mir-103a-1, hsa-mir-107, hsa-mir-16-2, mmu-mir-1a-1, mmu-mir-23b, mmu-mir-125b-2, mmu-mir-130a, mmu-mir-9-2, mmu-mir-145a, mmu-mir-181a-2, mmu-mir-184, mmu-mir-199a-1, hsa-mir-199a-1, mmu-mir-205, mmu-mir-206, hsa-mir-181a-2, hsa-mir-181b-1, hsa-mir-199a-2, hsa-mir-205, hsa-mir-181a-1, hsa-mir-214, hsa-mir-219a-1, hsa-mir-223, mmu-mir-302a, hsa-mir-1-2, hsa-mir-23b, hsa-mir-125b-1, hsa-mir-130a, hsa-mir-145, hsa-mir-9-1, hsa-mir-9-2, hsa-mir-9-3, hsa-mir-125b-2, hsa-mir-184, hsa-mir-206, mmu-mir-16-1, mmu-mir-16-2, mmu-mir-20a, mmu-mir-21a, mmu-mir-23a, mmu-mir-103-1, mmu-mir-103-2, rno-mir-338, mmu-mir-338, rno-mir-20a, hsa-mir-1-1, mmu-mir-1a-2, hsa-mir-181b-2, mmu-mir-107, mmu-mir-17, mmu-mir-100, mmu-mir-181a-1, mmu-mir-214, mmu-mir-219a-1, mmu-mir-223, mmu-mir-199a-2, mmu-mir-9-1, mmu-mir-9-3, mmu-mir-181b-1, mmu-mir-125b-1, hsa-mir-302a, hsa-mir-219a-2, mmu-mir-219a-2, hsa-mir-302b, hsa-mir-302c, hsa-mir-302d, hsa-mir-367, hsa-mir-372, hsa-mir-338, mmu-mir-181b-2, rno-mir-9a-1, rno-mir-9a-3, rno-mir-9a-2, rno-mir-16, rno-mir-17-1, rno-mir-21, rno-mir-23a, rno-mir-23b, rno-mir-100, rno-mir-103-2, rno-mir-103-1, rno-mir-107, rno-mir-125b-1, rno-mir-125b-2, rno-mir-130a, rno-mir-145, rno-mir-181a-2, rno-mir-181b-1, rno-mir-181b-2, rno-mir-184, rno-mir-199a, rno-mir-206, rno-mir-181a-1, rno-mir-214, rno-mir-219a-1, rno-mir-219a-2, rno-mir-223, hsa-mir-512-1, hsa-mir-512-2, rno-mir-1, mmu-mir-367, mmu-mir-302b, mmu-mir-302c, mmu-mir-302d, rno-mir-17-2, hsa-mir-1183, mmu-mir-1b, hsa-mir-302e, hsa-mir-302f, hsa-mir-103b-1, hsa-mir-103b-2, rno-mir-9b-3, rno-mir-9b-1, rno-mir-9b-2, rno-mir-219b, hsa-mir-23c, hsa-mir-219b, mmu-mir-145b, mmu-mir-21b, mmu-mir-21c, mmu-mir-219b, mmu-mir-219c, mmu-mir-9b-2, mmu-mir-9b-1, mmu-mir-9b-3
For example, the cluster of miR-512-3p, miR-205, and the miR-302 family illustrated on the heat map demonstrates high expression in undifferentiated ES and early neural progenitor stages, downregulation during the glial restricted and early OP transitions, but then additional high expression during mid to late OP development. [score:9]
Additionally, miR-205 showed a ∼9.2-fold downregulation during the OP3 to OL transition, which contains a conserved 8mer complementary site within the Cldn11 3′-UTR. [score:4]
During the final stage transition, miR-205 showed significant downregulation. [score:4]
As such, the decrease of miR-205 may be partially responsible for the increased expression of Cldn11 at this stage. [score:3]
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[+] score: 11
However, miR-15b, miR-16, miR-20a, miR-20b [17], [18], miR-205 [23] and miR-195 [22] down-regulate angiogenesis by directly targeting VEGF. [score:7]
Recent studies also indicate that a panel of miRNAs (i. e., miR-10, miR-15b, miR-16, miR-20a, miR-20b, miR-27a, miR-126, miR-145, miR-195, miR-205, and miR-210) is involved in the regulation of VEGF expression in ECs and tumor cells [16]– [26]. [score:4]
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[+] score: 8
miR-451 had only one predicted target in common between the databases, whereas miR-148a, miR-21 and miR-205 had 200 to 300 putative target genes. [score:5]
Based on qRT-PCR analysis, the expression of miR-451, miR-148a, miR-21, miR-205 and miR-193a were not different between the sexes and therefore contrasted the microarray results. [score:3]
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[+] score: 7
Additionally, Yuan et al. determined that thousands of miRNAs, such as miR-21, miR-17, and miR-92a, are up-regulated, whereas others, such as miR-205 and miR-145, are downregulated in the setting of femoral head repair using high-throughput gene chip technology [22]. [score:7]
[1 to 20 of 1 sentences]
[+] score: 6
Collectively, we conclude that APC and IPC are related to miR-1, miR-17, miR-133, and miR-205, which suppress the Akt–GSK–cyclin D1 pathway. [score:3]
Four miRNAs (miR-1, miR-17, miR-133, and miR-205) related to the Akt–GSK–cyclin D1 pathway were significantly down regulated by both APC and IPC treatment (p < 0.05, Table 2). [score:2]
[22] Iorio and colleagues demonstrated that miR-205 impairs activation of the Akt -mediated survival and proliferation pathway in vitro. [score:1]
[1 to 20 of 3 sentences]
[+] score: 5
Notably, a panel of 11 Runx2 -targeting miRNAs (miR-23a, miR-30c, miR-34c, miR-133a, miR-135a, miR-137, miR-204, miR-205, miR-217, miR-218, and miR-338) is expressed in a lineage-related pattern in mesenchymal cell types [20]. [score:5]
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[+] score: 5
For example, miR-17 [12] and miR-100 [13] were up regulated while miR-10a [14] and miR-205 [15] were downregulated during the osteogenic differentiation in bone mesenchymal stem cells of rats (rBMSCs). [score:5]
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[+] score: 4
Gregory PA Bert AG Paterson EL Barry SC Tsykin A Farshid G The miR-200 family and miR-205 regulate epithelial to mesenchymal transition by targeting ZEB1 and SIP1Nat Cell Biol. [score:4]
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[+] score: 4
Studies found that miR-141, miR-200b and miR-205 can prevent TGF-β -induced EMT by downregulating ZEB1 and ZEB2, the two major transcriptional repressors of E-cadherin [15], [16]. [score:4]
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[+] score: 4
miR-141, miR-200a, miR-192, and miR-205 are upregulated in patients with hypertensive glomerulosclerosis [43]. [score:4]
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[+] score: 4
Among the miRNAs upregulated in rat PSCs, we also identified miR-205 and members of the miR-200 family (miR-200a, miR-200b, miR-200c, miR-141 and miR-429), which promote mesenchymal to epithelial transition (MET) in mouse cells, a key step in fibroblast reprogramming [47]. [score:4]
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[+] score: 4
However miR-151*, miR-10a-5p, miR-205, miR-17-5p, miR-145 and miR-664 were up-regulated in the AcarH group (fold change>2, P<0.05, Table 2, Figure 4). [score:4]
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[+] score: 4
Other miRNAs from this paper: hsa-let-7a-1, hsa-let-7a-2, hsa-let-7a-3, hsa-let-7b, hsa-let-7c, hsa-let-7d, hsa-let-7e, hsa-let-7f-1, hsa-let-7f-2, hsa-mir-15a, hsa-mir-17, hsa-mir-19b-1, hsa-mir-19b-2, hsa-mir-23a, hsa-mir-24-1, hsa-mir-24-2, hsa-mir-25, hsa-mir-29a, hsa-mir-30a, hsa-mir-31, hsa-mir-32, hsa-mir-33a, hsa-mir-92a-1, hsa-mir-92a-2, hsa-mir-106a, mmu-let-7g, mmu-let-7i, mmu-mir-27b, mmu-mir-30a, mmu-mir-30b, mmu-mir-126a, mmu-mir-9-2, mmu-mir-135a-1, mmu-mir-137, mmu-mir-140, mmu-mir-150, mmu-mir-155, mmu-mir-24-1, mmu-mir-193a, mmu-mir-194-1, mmu-mir-204, mmu-mir-205, hsa-mir-30c-2, hsa-mir-30d, mmu-mir-143, mmu-mir-30e, hsa-mir-34a, hsa-mir-204, hsa-mir-205, hsa-mir-222, mmu-let-7d, mmu-mir-106a, mmu-mir-106b, hsa-let-7g, hsa-let-7i, hsa-mir-27b, hsa-mir-30b, hsa-mir-135a-1, hsa-mir-135a-2, hsa-mir-137, hsa-mir-140, hsa-mir-143, hsa-mir-9-1, hsa-mir-9-2, hsa-mir-9-3, hsa-mir-126, hsa-mir-150, hsa-mir-193a, hsa-mir-194-1, mmu-mir-19b-2, mmu-mir-30c-1, mmu-mir-30c-2, mmu-mir-30d, mmu-mir-200a, mmu-let-7a-1, mmu-let-7a-2, mmu-let-7b, mmu-let-7c-1, mmu-let-7c-2, mmu-let-7e, mmu-let-7f-1, mmu-let-7f-2, mmu-mir-15a, mmu-mir-23a, mmu-mir-24-2, mmu-mir-29a, mmu-mir-31, mmu-mir-92a-2, mmu-mir-34a, rno-mir-322-1, mmu-mir-322, rno-let-7d, rno-mir-329, mmu-mir-329, rno-mir-140, rno-mir-350-1, mmu-mir-350, hsa-mir-200c, hsa-mir-155, mmu-mir-17, mmu-mir-25, mmu-mir-32, mmu-mir-200c, mmu-mir-33, mmu-mir-222, mmu-mir-135a-2, mmu-mir-19b-1, mmu-mir-92a-1, mmu-mir-9-1, mmu-mir-9-3, mmu-mir-7b, hsa-mir-194-2, mmu-mir-194-2, hsa-mir-106b, hsa-mir-30c-1, hsa-mir-200a, hsa-mir-30e, hsa-mir-375, mmu-mir-375, mmu-mir-133b, hsa-mir-133b, rno-let-7a-1, rno-let-7a-2, rno-let-7b, rno-let-7c-1, rno-let-7c-2, rno-let-7e, rno-let-7f-1, rno-let-7f-2, rno-let-7i, rno-mir-7b, rno-mir-9a-1, rno-mir-9a-3, rno-mir-9a-2, rno-mir-17-1, rno-mir-19b-1, rno-mir-19b-2, rno-mir-23a, rno-mir-24-1, rno-mir-24-2, rno-mir-25, rno-mir-27b, rno-mir-29a, rno-mir-30c-1, rno-mir-30e, rno-mir-30b, rno-mir-30d, rno-mir-30a, rno-mir-30c-2, rno-mir-31a, rno-mir-32, rno-mir-33, rno-mir-34a, rno-mir-92a-1, rno-mir-92a-2, rno-mir-106b, rno-mir-126a, rno-mir-135a, rno-mir-137, rno-mir-143, rno-mir-150, rno-mir-193a, rno-mir-194-1, rno-mir-194-2, rno-mir-200c, rno-mir-200a, rno-mir-204, rno-mir-222, hsa-mir-196b, mmu-mir-196b, rno-mir-196b-1, mmu-mir-410, hsa-mir-329-1, hsa-mir-329-2, mmu-mir-470, hsa-mir-410, hsa-mir-486-1, hsa-mir-499a, rno-mir-133b, mmu-mir-486a, hsa-mir-33b, rno-mir-499, mmu-mir-499, mmu-mir-467d, hsa-mir-891a, hsa-mir-892a, hsa-mir-890, hsa-mir-891b, hsa-mir-888, hsa-mir-892b, rno-mir-17-2, rno-mir-375, rno-mir-410, mmu-mir-486b, rno-mir-31b, rno-mir-9b-3, rno-mir-9b-1, rno-mir-126b, rno-mir-9b-2, hsa-mir-499b, mmu-let-7j, mmu-mir-30f, mmu-let-7k, hsa-mir-486-2, mmu-mir-126b, rno-mir-155, rno-let-7g, rno-mir-15a, rno-mir-196b-2, rno-mir-322-2, rno-mir-350-2, rno-mir-486, mmu-mir-9b-2, mmu-mir-9b-1, mmu-mir-9b-3
For instance, among the 66 uniformly expressed miRNAs for which IPA assigned functions, we identified 12 candidates that have been implicated in androgen regulation, including: let-7a-5p, miR-15a-5p, miR-17-5p, miR-19b-3p, miR-23a-3p, miR-24-3p, miR-27b-3p, miR-30a-5p, miR-34a-5p, miR-140-5p, miR-193a-3p, miR-205-5p (S1 Fig). [score:4]
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[+] score: 2
Other miRNAs from this paper: hsa-mir-205, hsa-mir-200c, rno-mir-200c
Wang D. Wang S. Liu Q. Wang M. Wang C. Yang H. SZ-685C exhibits potent anticancer activity in both radiosensitive and radioresistant NPC cells through the miR-205-PTEN-Akt pathway Oncol. [score:1]
Wang et al. reported that SZ-685C displayed a potent cytocidal effect in both radiosensitive and radioresistant human nasopharyngeal carcinoma (NPC) cells via the miR-205-PTEN-Akt pathway [16]. [score:1]
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[+] score: 2
Additionally, 34 miRNAs were significantly deregulated due to sham laparotomy but were unaffected following PH (e. g., rno-miR-205, rno-miR-295, rno-miR-337 and rno-miR-708). [score:2]
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