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10 publications mentioning gga-mir-128-1

Open access articles that are associated with the species Gallus gallus and mention the gene name mir-128-1. Click the [+] symbols to view sentences that include the gene name, or the word cloud on the right for a summary.

[+] score: 68
Besides, inhibition of miR-128 reduced differentiation of myogenic satellite cells in turkeys [40], and miR-128 overexpression inhibited proliferation but promoted myotube formation by targeted myostatin mRNA in mouse C2C12 myoblast cells [41]. [score:9]
Here, we found that miR-128 has lower expression in the SLD chickens skeletal muscle than in normal chickens at 7w, and it is specifically up-regulated from E14 to 7w in the SLD chicken muscle. [score:6]
Reduced expression of miR-128 in the SLD chicken might release the expression of myostatin and induce muscle mass loss. [score:5]
Finally, we confirmed that the expressions of let-7b, miR-128 and miR-187 are differentially expressed between the SLD chickens and normal chickens at 7w by using qPCR assays (Figure 3d), and the Western Blotting results also showed that the expression of phospho-ERK1/2 is reduced in the SLD chicken compared to that in normal chickens at 7w (Figure 3e). [score:5]
These analyses identified that let-7b, miR-128 and the MAPK pathway are important for chicken muscle development, and their different expressions or activities during muscle development might lead to differences in muscle performance between the SLD and normal chickens. [score:5]
Additionally, the qPCR results showed that the expressions of let-7b, miR-128 and miR-187 have no significant difference between the SLD chickens and normal chickens at E14 (Figure 3f), but the expression of phospho-ERK1/2 is also reduced in the SLD chickens compared to that of in normal chickens at E14 (Figure 3g). [score:4]
Thus, based on the integrative analysis of miRNA-mRNA interactions, we conclude that abnormal expressions of let-7b, miR-128, the MAPK pathway and the negative regulation of cell proliferation may be critical for the muscle mass loss in the SLD chicken. [score:4]
Among these pathways, the PI3K-Akt and MAPK signaling pathways implicated in muscle development were found to be involved in the target pathways of let-7b and miR-128 (Figure 3b and Table S1). [score:4]
Shi L. Zhou B. Li P. Schinckel A. P. Liang T. Wang H. Li H. Fu L. Chu Q. Huang R. MicroRNA-128 targets myostatin at coding domain sequence to regulate myoblasts in skeletal muscle development Cell Signal. [score:4]
In tumor cells, expression of miR-128 is dysregulated with a profound effect on tumorigenesis. [score:4]
Altogether, these results suggested that let-7b, miR-128 and the MAPK signaling pathway are the most important potential targets that are related to the difference of muscle performance between SLD and normal chickens at 7w of age. [score:3]
miR-128 is a brain-enriched miRNA that plays a critical role in nervous system development [38]. [score:2]
This network showed that let-7b and miR-128 are involved in the regulation of many DEMs (Figure 3c). [score:2]
Network and pathway analysis showed the key roles of miR-128 during the SLD chicken skeletal muscle development. [score:2]
In conclusion, our study revealed that let-7b, miR-128 and the MAPK pathway are potential key molecules and the pathway implicated in GHR -deficient induced muscle mass loss, and that the reduced cell division, growth and developmental process in the SLD chicken skeletal muscle may be the molecular reasons that result in the muscle mass loss. [score:2]
Therefore, we suggest that miR-128 may play key roles in skeletal muscle development in the SLD chickens. [score:2]
Dysregulation of miR-128 can also alter the proliferation, differentiation and metabolism of the tumor cells [39]. [score:2]
The core nodes for this network are let-7b, miR-128 and miR-187. [score:1]
Finally, by analyzing the functions of these DEGs and DEMs, we also found that several molecules and pathways, such as let-7b, miR-128, and the MAPK signaling pathways, may be the key nodes or pathways that play critical roles in the GHR -deficient induced muscle mass loss. [score:1]
Huang D. Q. Guo P. Lv N. H. Luo L. Y. MiR-128, a key regulator of oncogenic properties Mol. [score:1]
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[+] score: 18
Starting with 16 known miRNAs validated as differentially expressed between broilers and layers, and eight muscle-related miRNAs (gga-miR-1, gga-miR-206, gga-miR-499, gga-miR-221, gga-miR-222, gga-miR-128, gga-miR-367 and gga-miR-27b), TargetScan (version 5.1) [43] was used to predict putative targets. [score:7]
GERM1, a putative target of gga-miR-128, encodes a protein that is a BMP4 antagonist and an effective regulator of myogenic progenitor proliferation [62]. [score:4]
Nr5a2 is the putative target of gga-miR-200b, gga-miR-128 and gga-miR-27b. [score:3]
Of these 13 miRNAs, five (miR-206, miR-1a, miR499, miR-128 and miR-27b) have been reported to have a role during muscle development [30, 50]. [score:2]
In addition to miR-206, miR-1 and miR-181, nine other miRNAs among the most abundant in these libraries (miR-221, miR-222, miR-21, miR-103, miR-130, miR-99, miR-30, miR20, and miR128) have been implicated in the proliferation and differentiation of muscle cells (Table 1) [15, 19, 33]. [score:1]
In some cases, such as gga-miR-222 and gga-miR-128, more than one highly abundant isoform was present (Figure 3), indicating that some miRNAs have more than one functional isoform in specific tissues/organs. [score:1]
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[+] score: 13
Expression of let-7b and miR-128 in 7-week-old chickens was significantly up-regulated and down-regulated, respectively. [score:9]
At the same developmental stages, different expression profiles in skeletal muscles of dwarf and normal chickens occurred for four miRNAs (miR-1623, miR-181b, let-7b, and miR-128). [score:4]
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[+] score: 13
Sequence alignments show miR predicted targets sites within the 3’UTR of chick Spry2 and chick microRNA sequences of mir-21, mir-23, mir-27, mir-122, and miR-128. [score:3]
In our hands, only mir-23, mir-27 and mir-128 showed strong expression in somites (Figure 6B). [score:3]
Our analysis of Targetscan followed by Northern blots of developing somites showed that mir-23, mir-27 and mir-128 could be part of this negative feedback loop mechanism. [score:3]
The analysis showed that mir-21, mir-23, mir-27, mir-122 and mir-128 can potentially interact with Spry2 through binding to its 3’UTR (Figure 6A). [score:1]
However, further analysis using gain- and loss-of-function of mir-23, mir-27 and mir-128 is required to proof or to exclude an interaction with FGF/Spry2 signalling. [score:1]
RNA was transferred to five membranes (Hybond NX, Amersham Biosciences) then hybridized to [32]P-labeled antisense probes (end -labelled with [γ- [32]P]ATP and T4 kinase) complementary to the mature mirRNA of gga-miR-21, gga-miR-23, gga-miR-27, gga-miR-122 and gga-miR-128 that cover the entire length of the miRNAs. [score:1]
We also propose that mir-23, mir-27 and mir-128 could be part of the negative feedback loop mechanism. [score:1]
[1 to 20 of 7 sentences]
[+] score: 11
The results indicated that nine genes, which were enriched in the glycerophospholipid metabolism pathway, were specifically targeted by down-regulated miRNAs, and five of these nine genes were targeted by miR-128-3p. [score:8]
Five of the potential targets of miR-128-3p were present in the glycerophospholipid metabolism biological pathway. [score:3]
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[+] score: 5
Other miRNAs from this paper: hsa-let-7a-1, hsa-let-7a-2, hsa-let-7a-3, hsa-mir-15a, hsa-mir-18a, hsa-mir-33a, hsa-mir-103a-2, hsa-mir-103a-1, hsa-mir-107, mmu-mir-27b, mmu-mir-126a, mmu-mir-128-1, mmu-mir-140, mmu-mir-146a, mmu-mir-152, mmu-mir-155, mmu-mir-191, hsa-mir-10a, hsa-mir-211, hsa-mir-218-1, hsa-mir-218-2, mmu-mir-297a-1, mmu-mir-297a-2, hsa-mir-27b, hsa-mir-128-1, hsa-mir-140, hsa-mir-152, hsa-mir-191, hsa-mir-126, hsa-mir-146a, mmu-let-7a-1, mmu-let-7a-2, mmu-mir-15a, mmu-mir-18a, mmu-mir-103-1, mmu-mir-103-2, mmu-mir-342, hsa-mir-155, mmu-mir-107, mmu-mir-10a, mmu-mir-218-1, mmu-mir-218-2, mmu-mir-33, mmu-mir-211, hsa-mir-374a, hsa-mir-342, gga-mir-33-1, gga-let-7a-3, gga-mir-155, gga-mir-18a, gga-mir-15a, gga-mir-218-1, gga-mir-103-2, gga-mir-107, gga-mir-140, gga-let-7a-1, gga-mir-146a, gga-mir-103-1, gga-mir-218-2, gga-mir-126, gga-let-7a-2, gga-mir-27b, mmu-mir-466a, mmu-mir-467a-1, hsa-mir-499a, hsa-mir-545, hsa-mir-593, hsa-mir-600, hsa-mir-33b, gga-mir-499, gga-mir-211, gga-mir-466, mmu-mir-675, mmu-mir-677, mmu-mir-467b, mmu-mir-297b, mmu-mir-499, mmu-mir-717, hsa-mir-675, mmu-mir-297a-3, mmu-mir-297a-4, mmu-mir-297c, mmu-mir-466b-1, mmu-mir-466b-2, mmu-mir-466b-3, mmu-mir-466c-1, mmu-mir-466e, mmu-mir-466f-1, mmu-mir-466f-2, mmu-mir-466f-3, mmu-mir-466g, mmu-mir-466h, mmu-mir-467c, mmu-mir-467d, mmu-mir-466d, hsa-mir-297, mmu-mir-467e, mmu-mir-466l, mmu-mir-466i, mmu-mir-466f-4, mmu-mir-466k, mmu-mir-467f, mmu-mir-466j, mmu-mir-467g, mmu-mir-467h, hsa-mir-664a, hsa-mir-1306, hsa-mir-1307, gga-mir-1306, hsa-mir-103b-1, hsa-mir-103b-2, gga-mir-10a, mmu-mir-1306, mmu-mir-3064, mmu-mir-466m, mmu-mir-466o, mmu-mir-467a-2, mmu-mir-467a-3, mmu-mir-466c-2, mmu-mir-467a-4, mmu-mir-466b-4, mmu-mir-467a-5, mmu-mir-466b-5, mmu-mir-467a-6, mmu-mir-466b-6, mmu-mir-467a-7, mmu-mir-466b-7, mmu-mir-467a-8, mmu-mir-467a-9, mmu-mir-467a-10, mmu-mir-466p, mmu-mir-466n, mmu-mir-466b-8, hsa-mir-466, hsa-mir-3173, hsa-mir-3618, hsa-mir-3064, hsa-mir-499b, mmu-mir-466q, hsa-mir-664b, gga-mir-3064, mmu-mir-126b, gga-mir-33-2, mmu-mir-3618, mmu-mir-466c-3, gga-mir-191
Out of the 26 miRNA/host gene pairs with coordinated expression, 11 have been found to be coordinately expressed in both, human and mouse [19], [27], [59], [61]– [64], [67]– [69], [71], [73]– [79]: mir-103/ PANK3, mir-107/ PANK1, mir-126/ EGFL7, mir-128-1/ R3HDM1, mir-140/ WWP2, mir-211/ TRPM1, mir-218-1/ SLIT2, mir-218-2/ SLIT3, mir-27b/ C9orf3, mir-33/ SREBF2, and mir-499/ MYH7B. [score:5]
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[+] score: 4
During the same developmental stage, miR-1623, miR-181b, let-7b, and miR-128 were differentially expressed in the skeletal muscle of dwarf and normal chickens [10]. [score:4]
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[+] score: 1
Integrative analyses of miRNA-mRNA interactions reveal let-7b, miR-128 and MAPK pathway involvement in muscle mass loss in sex-linked dwarf chickens. [score:1]
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[+] score: 1
MiR-18, miR-98, miR-128, miR-135, and miR-148 affect ovarian cell steroidogenesis, including the production of progesterone, testosterone, and estradiol [17]. [score:1]
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[+] score: 1
MiR-128-1 and miR-148a reduce hepatic levels of proteins involved in lipid trafficking and metabolism and levels of circulating cholesterol and TG [28]. [score:1]
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