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12 publications mentioning hsa-mir-1973

Open access articles that are associated with the species Homo sapiens and mention the gene name mir-1973. Click the [+] symbols to view sentences that include the gene name, or the word cloud on the right for a summary.

1
[+] score: 16
At least some of the highly scored targets may represent an integrated network with miRNAome and act in concert in irradiated hESCs; for example, LIN9, a putative target of hsa-mir-1973, regulates MYB which is by itself is predicted to be a target of hsa-mir-15b (Table S3), and crucially affects the cell cycle machinery through the cyclins and CDK1 [74]. [score:8]
Gene expression studies showed that IR -induced alterations in miRNAome in H9 cell line (2 hr post-IR) involve the up-regulation of only two miRNA genes, namely, hsa-miR-1973 and hsa-miR-92a (Table 2). [score:6]
Further bioinformatics analyses revealed that only seven miRNA genes were differentially expressed in H1 at the “early” (2 hr) time point post-IR (p<0.05) (Figure 1); among them, only four miRNA species showed more than 1.5 – fold induction compared to sham-irradiated cells (hsa-miR-15b, hsa-miR-1274b, hsa-miR-302b and hsa-miR-1973) (Table 1). [score:2]
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2
[+] score: 12
Six under-expressed microRNAs that were altered at least four fold, including hsa-miR-3646, hsa-miR-17*, hsa-miR-3679-3p, hsa-miR-17, hsa-miR-155, and hsa-miR-146a, (Figure 5A) and ten under-expressed microRNAs that were highly expressed (normalized data ≥6), including hsa-miR-100, hsa-miR-10a, hsa-miR-130b, hsa-miR-146a, hsa-miR-17, hsa-miR-1973, hsa-miR-29a, hsa-miR-31, hsa-miR-31* and hsa-miR-762 (Figure 5B), were selected for further qRT-PCR analyses. [score:7]
The expression of five underexpressed microRNAs including miR-155, miR-146a, miR-1973, miR-29a and miR-31during hepatic differentiation in L02 and HepG2 was lower than in hUC-MSCs. [score:5]
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3
[+] score: 9
Other miRNAs from this paper: hsa-let-7b, hsa-mir-15a, hsa-mir-19a, hsa-mir-19b-1, hsa-mir-19b-2, hsa-mir-27a, hsa-mir-28, hsa-mir-30a, hsa-mir-100, hsa-mir-30c-2, hsa-mir-30d, hsa-mir-181a-2, hsa-mir-210, hsa-mir-181a-1, hsa-mir-221, hsa-mir-1-2, hsa-mir-15b, hsa-mir-30b, hsa-mir-122, hsa-mir-132, hsa-mir-141, hsa-mir-191, hsa-mir-9-1, hsa-mir-9-2, hsa-mir-9-3, hsa-mir-125a, hsa-mir-195, hsa-mir-200c, hsa-mir-1-1, hsa-mir-30c-1, hsa-mir-34b, hsa-mir-34c, hsa-mir-30e, hsa-mir-371a, hsa-mir-372, hsa-mir-373, hsa-mir-375, hsa-mir-151a, hsa-mir-429, hsa-mir-449a, hsa-mir-483, hsa-mir-193b, hsa-mir-520e, hsa-mir-520f, hsa-mir-520a, hsa-mir-520b, hsa-mir-520c, hsa-mir-520d, hsa-mir-520g, hsa-mir-520h, hsa-mir-548a-1, hsa-mir-548b, hsa-mir-548a-2, hsa-mir-548a-3, hsa-mir-548c, hsa-mir-548d-1, hsa-mir-548d-2, hsa-mir-449b, hsa-mir-151b, hsa-mir-320b-1, hsa-mir-320b-2, hsa-mir-891a, hsa-mir-935, hsa-mir-1233-1, hsa-mir-548e, hsa-mir-548j, hsa-mir-548k, hsa-mir-548l, hsa-mir-548f-1, hsa-mir-548f-2, hsa-mir-548f-3, hsa-mir-548f-4, hsa-mir-548f-5, hsa-mir-548g, hsa-mir-548n, hsa-mir-548m, hsa-mir-548o, hsa-mir-548h-1, hsa-mir-548h-2, hsa-mir-548h-3, hsa-mir-548h-4, hsa-mir-1275, hsa-mir-548p, hsa-mir-548i-1, hsa-mir-548i-2, hsa-mir-548i-3, hsa-mir-548i-4, hsa-mir-548q, hsa-mir-548s, hsa-mir-548t, hsa-mir-548u, hsa-mir-548v, hsa-mir-548w, hsa-mir-548x, hsa-mir-1233-2, hsa-mir-548y, hsa-mir-548z, hsa-mir-548aa-1, hsa-mir-548aa-2, hsa-mir-548o-2, hsa-mir-548h-5, hsa-mir-548ab, hsa-mir-548ac, hsa-mir-548ad, hsa-mir-548ae-1, hsa-mir-548ae-2, hsa-mir-548ag-1, hsa-mir-548ag-2, hsa-mir-548ah, hsa-mir-548ai, hsa-mir-548aj-1, hsa-mir-548aj-2, hsa-mir-548x-2, hsa-mir-548ak, hsa-mir-548al, hsa-mir-548am, hsa-mir-548an, hsa-mir-371b, hsa-mir-548ao, hsa-mir-548ap, hsa-mir-548aq, hsa-mir-548ar, hsa-mir-548as, hsa-mir-548at, hsa-mir-548au, hsa-mir-548av, hsa-mir-548aw, hsa-mir-548ax, hsa-mir-548ay, hsa-mir-548az, hsa-mir-548ba, hsa-mir-548bb, hsa-mir-548bc
Finally, hsa-miR-19b [47, 54] and hsa-miR-483-5p [47, 53], which are upregulated, and hsa-miR-28-5p [47, 53], hsa-miR-19a [48, 53] and hsa-miR-1973 [48, 51], which are downregulated, are expressed in spermatozoa, but they have not been associated with spermatogenesis or related processes. [score:9]
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4
[+] score: 7
Other miRNAs from this paper: hsa-mir-4485
Moreover, they reported that hsa-miR-1973 and hsa-miR-4485 are upregulated in senescent endothelial cells and propose that these miRs are derived from the ASncmtRNA-2 stem by Dicer processing [50]. [score:4]
Indeed, we found that following ASK, MDA-MB-231 (human breast carcinoma) cells with ASO-1537S [6] for 24 h, hsa-miR-1973 and hsa-miR-4485 are overexpressed about 7-10 times compared to control cells (M. Briones and C. Fitzpatrick, unpublished results). [score:2]
Although murine homologues of hsa-miR-1973 and hsa-miR-4485 cannot be currently found in miR databases, the corresponding regions on the mASncmtRNAs display sequence identities of 100% to human for miR-1973, 93% for miR-4485-5p and 90% for miR-4485-3p, suggesting that these segments on the double-stranded region of the ASncmtRNAs could give rise to murine homologues of the corresponding miRs. [score:1]
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5
[+] score: 4
Nineteen of the downregulated miRNAs in chronic patients were found to be associated with carcinogenesis in various organs and tissues, such as miR-1207 [40], miR-3162-5p [41, 42], miR-3196 [43, 44], miR-371b-5p [45], miR-574-5p [46, 47], miR-1225-5p [48], miR-4485 [49], miR-572 [50], miR-4299 [51], miR-3679-5p [52], miR-3940-5p [53], miR-638 [54, 55], miR-1202 [56], miR-5787 [57], miR-1973 [58], miR-4532 [59], miR-1275 [60], miR-4728-5p [61], and miR-1915-3p [62]. [score:4]
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6
[+] score: 4
Eleven of the up-regulated miRNAs (miR-887, miR-583, miR-662, miR-1973, miR-718, miR-1268, miR-2117, miR-614, miR-617, miR-1972, and miR-1181) have no reported functions in cancer cells yet. [score:4]
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7
[+] score: 3
Of these 14 miRNAs, four (has-mir-1973, 494, 4286 and 29b-3p) showed a 2.99- to 4.44-fold increase in their expression. [score:3]
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8
[+] score: 3
Other miRNAs from this paper: hsa-let-7e, hsa-mir-124-1, hsa-mir-124-2, hsa-mir-124-3, hsa-mir-638
qPCR closely validated the array expression of miRNA tested (Figure 2b, miR-1973 representative) with R [2] = 0.88 (Figure 2c). [score:3]
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9
[+] score: 3
Eleven microRNAs that were differentially expressed and common in 2 of the 4 cell types were found to be miR-17, miR-21, miR-29c, miR-141, miR-142-3p, miR-215, miR-494, miRPlus-E1072, miRPlus-E1192, miR-1248, and miR-1973 (Fig. 5). [score:3]
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10
[+] score: 1
While 44 miRNAs showed a greater enrichment in the cytosolic Hy3-labeled RNA fraction, 13 miRNAs were significantly and reproducibly enriched in the mitochondrial Hy5-labeled RNA sample (ranging from 1.5- to 56-fold), namely hsa-miR-1973, hsa-miR-1275, hsa-miR-494, hsa-miR-513a-5p, hsa-miR-1246, hsa-miR-328, hsa-miR-1908, hsa-miR-1972, hsa-miR-1974, hsa-miR-1977, hsa-miR-638, hsa-miR-1978 and hsa-miR-1201 (Figure 5A). [score:1]
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11
[+] score: 1
Experiments have shown that miR-494, miR-1973 and miR-21 could not only be used as diagnostic biomarkers but also circulating cell-free treatment response biomarkers in HL [73]. [score:1]
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12
[+] score: 1
Seven human miRNAs (hsa-miR-1291, hsa-miR-1246, hsa-miR-1248, hsa-miR-1274b, hsa-miR-1973, hsa-miR-4284 and hsa-miR-3656) could be accurately mapped to other ncRNAs, which included snoRNAs, snRNAs, tRNAs and rRNAs (Table 1). [score:1]
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