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19 publications mentioning ssc-mir-10a

Open access articles that are associated with the species Sus scrofa and mention the gene name mir-10a. Click the [+] symbols to view sentences that include the gene name, or the word cloud on the right for a summary.

1
[+] score: 44
The results of transient transfection assays demonstrated that (1) miR-21 negatively regulates the expression of Pitx2c (this work), (2) miR-1 suppresses Myocd expression [53], and (3) miR-10a and miR-10b both inhibit Tbx5 expression [54]. [score:11]
Downregulation of miR-1, miR-10a, miR-29a, and miR-208a has been implicated in chronic AF [7, 13, 59], while these miRNAs were highly upregulated in the porcine LA in response to brief paroxysms of AF. [score:7]
An aspect of particular interest of our study was the finding that the upregulation of miR-1, miR-10a, miR-10b, and miR-21 is negatively correlated with downregulation of, respectively, MYOCD, TBX5, and PITX2c in the paced LA (see Figure 5(e)). [score:7]
In transfection assays, miR-1 inhibits mouse Myocd expression at the transcript [52] and protein level [53], while both miR-10a and miR-10b negatively modulate human Tbx5 expression at the protein level [54]. [score:6]
Computational analysis (by miRanda and Targetscan) of the 3′ untranslated region of pig Pitx2, Tbx5, and Myocd genes revealed consensus sites for binding of, respectively, miR-21, miR-10a/miR-10b, and miR-1 (Figure 5(a)). [score:5]
Our qPCR analysis showed that pacing resulted in a significant upregulation of a set of AF -associated miRNAs (i. e., miR-1, miR-10a, miR-10b, miR-21, miR-29a, and miR-208a) in the LA compared with the control (see Figure 3). [score:3]
Pacing -induced alterations in the expression of other miRNAs with particular concern for their involvement in AF could not be determined by microarray hybridizations due to a high variability among replicates (miR-1, miR-21, miR-23a/b, miR-29a, and miR-133a) or very low hybridization signals (miR-10a, miR-10b; see the complete microarray data at NCBI through GEO accession number GSE65330). [score:3]
Six miRNAs (miR-1, miR-10a-5p, miR-10b, miR-21, miR-29a, and miR-208a) showed a higher expression in paced as compared with nonpaced animals. [score:2]
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2
[+] score: 36
In this study, the results of integrated expression analysis showed that miR-143-3p, miR-30a-5p, miR-novel-chr2_21624, miR-148a-3p, miR-27b-3p and miR-10a-5p were significantly upregulated in PCMV-infected thymus, while the expression of their target genes, which are related to the TLR and RLR signalling pathways, were significantly downregulated (Table 2). [score:13]
According to the high-throughput sequencing data, the let-7 family (let-7a, let-7f, let-7 g), the miR-10 family (miR-10b, miR-10a-3p, miR-10a-5p), miR-21, miR-143-3p, miR-30a-5p, miR-16 and miR-192 had the highest expression levels among the 10 expression profiles (Additional file  1: Figure S3), which suggests that these miRNAs are highly conserved among different organs in the same species. [score:5]
Recent reports have shown that miR-10a inhibits the immune responses of Th1/Th17 cells and dendritic cell activation by targeting IL-12/IL-23p40. [score:5]
In this study, miR-10a-3p was generally significantly upregulated in PCMV-infected lung (278% increase), liver (200% increase), thymus (153% increase) and kidney (2.53% increase). [score:4]
Our recent studies showed that miR-10a-3p is upregulated in PCMV-infected porcine macrophages and Japanese encephalitis virus-infected porcine kidney epithelial cells (PK-15). [score:4]
control Log2 (Fold change value) Target gene related signaling pathways miR-10a-5p +2.53 TLR6 −2.88 Toll-like receptor signaling pathway miR-10a-5p +2.53 TLR7 −2.01 Toll-like receptor signaling pathway miR-27b-3p +4.84 PIK3CG −2.77 Toll-like receptor signaling pathway miR-27b-3p +4.84 JAK2 −2.15 Toll-like receptor signaling pathway miR-27b-3p +4.84 DHX58 −4.95 RIG-I-like receptor signaling pathway miR-30a-5p +3.99 CXCL9 −3.93 Toll-like receptor signaling pathway miR-30a-5p +3.99 IL12B −4.2 Toll-like receptor signaling pathway miR-30a-5p +3.99 IL12B −4.2 RIG-I-like receptor signaling pathway miR-30a-5p +3.99 MAP3K1 −3.03 RIG-I-like receptor signaling pathway miR-30a-5p +3.99 TANK −2.09 RIG-I-like receptor signaling pathway miR-143-3p +6.68 CD40 −4.97 Toll-like receptor signaling pathway miR-143-3p +6.68 JAK3 −2.69 Toll-like receptor signaling pathway miR-143-3p +6.68 DDX58 −4.44 RIG-I-like receptor signaling pathway miR-143-3p +6.68 IKBKB −2.16 RIG-I-like receptor signaling pathway miR-148a-3p +2.46 MAPK14 −3.77 Toll-like receptor signaling pathway miR-148a-3p +2.46 STAT1 −2. [score:3]
miR-10a has also been determined to be negatively regulated by microbes, thereby promoting the maintenance of intestinal homeostasis in the host [39, 40]. [score:2]
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3
[+] score: 18
miR-10 expression was upregulated in the infected cells. [score:6]
Mitogen-activated protein kinase kinase kinase 7 (MAP3K7), considered a target gene of miR-10, regulates the inhibitor of nuclear factor κB/nuclear factor κB (IκB/NF-κB) signaling pathway [18]. [score:5]
We surmise that a possible function of miR-10 in triggering an antiviral response is targeting the MAP3K7 and BDNF genes. [score:3]
In addition, miR-10 controls brain-derived neurotrophic factor (BDNF) levels via the miRNA–mRNA regulatory network [19]. [score:2]
We detected miR-10 and miR-30 in this study, suggesting that they are related to the cellular immune response to PPV infection. [score:1]
Many immune-related miRNAs have been identified in innate and adaptive immune systems, including the miR-17—92 cluster, miR-221, miR-10, miR-196b, miR-126, miR-155, miR-150; miR-181a, miR-326, miR-142-3p, miR-424, miR-21, miR-106a, miR-223, miR-146; the let-7 family, miR-9, and miR-34 [6]. [score:1]
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4
[+] score: 17
To further support our results, miR-10a has been linked to the regulation of inflammation in endothelial cells [35], litter size in pigs was negatively associated with a single nucleotide polymorphism (SNP) in miR-27a expression [36], and miR-29c suppressed migration, invasion, and metastasis in nasopharyngeal carcinoma [37], [38]. [score:6]
We have listed miRNAs which are expressed during early porcine pregnancy, found significant differences in the miRNA populations between maternal and fetal tissue, and implicated the maternal expression of miR-10a, 27a, 29c, 323, 331-5p, 339-3p, 374b-5p, and 935 in spontaneous loss during early gestation. [score:5]
This is the first report of the association between miR-10a, 27a, 29c, 323, 331-5p, 339-3p, 374-5p, and 935 and spontaneous fetal arrest. [score:1]
Of the 8 significant differences observed by microarray between healthy endometrium and arresting endometrium, 7 miRNAs (miR-10a, 27a, 29c, 323, 331-5p, 339-3p, and 374b-5p) were assessed by Real-Time PCR but the results could not be validated. [score:1]
Of the 236 miRNAs probed in the microarray, 12 (miR-10a, 27a, 29a, 29c, 30b-5p, 99a, 148a, 148b, 323, 331-5p, 339-3p, and 374b-5p) were selected for secondary validation by quantitative Real-Time PCR. [score:1]
The expression levels of 12 miRNAs (miR-10a, 27a, 29a, 29c, 30b-5p, 99a, 148a, 148b, 323, 331-5p, 339-3p, and 374b-5p) were measured in all samples by Real-Time PCR to validate microarray results (Figure 4). [score:1]
Of the 47 significant differences observed by microarray in miRNA transcripts between healthy endometrium and healthy trophoblast, 7 miRNAs (miR-10a, 27a, 29a, 29c, 99a, 148b, and 323) were assessed by Real-Time PCR. [score:1]
ssc-miR-10a (JX185556); ssc-miR-29a (JX185557); ssc-miR-30b-5p (JX185558); ssc-miR-99a (JX185559); ssc-miR-148b (JX185560); ssc-miR-323 (JX185552); ssc-miR-331-5p (JX185553); ssc-miR-339-3p (JX185554); ssc-miR-374b-5p (JX185562); RNU1A (JN617883); AhR (KC012627), CCNG1 (KC012621); CDC42 (KC012622); DNMT3A (KC012620); FADD (KC012625); FOXO1 (KC012619); GPR37 (KC012626); IFI30 (KC012618); MMD (KC012628); USF2 (KC012623); USP46 (KC012624). [score:1]
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5
[+] score: 14
In this study, epigenomic-wide comparisons between athero-susceptible and -protected sites revealed a sharp distinction of DNA methylation in the HOX loci, which are associated with our previously identified differentially expressed genes, including HOXA4/5/7/10/11 and mir-10a/b [4, 14, 57]. [score:3]
Methylation-specific PCR (MSP) confirmed differential CpG methylation of HOXA genes, the ER stress gene ATF4, inflammatory regulator microRNA-10a and ARHGAP25 that encodes a negative regulator of Rho GTPases involved in cytoskeleton remo deling. [score:3]
MeDIP-seq and MSP (Fig.   7) confirmed AA hypomethylation of ATF4 (Fig.   7a) and HOXD4 (Fig.   7d) at a distal regulatory site and in the gene body respectively, and AA hypermethylation of mir-10a (Fig.   7b), HOXA5 (Fig.   7c), and ARHGAP25 (Fig.   7e). [score:2]
ATF4 is a key transcription factor in regulating cellular response to ER stress and unfolded protein response [6], while mir-10a plays an anti-inflammatory role by modulating NF-κB signaling [14]. [score:2]
The athero-protective and anti-inflammatory mir-10a was decreased by 71 % in AA, while its promoter was highly methylated in AA (2.3 fold of DT). [score:1]
Similar inverse mRNA/methylation relationships were noted for mir-10a, HOXA5 and ARHGAP25 (Figs.   7b,c,e). [score:1]
mRNA data for ATF4 and microRNA-10a were adapted from Civelek et al. [6]. [score:1]
We tested the DNA methylation in activating transcription factor 4 (ATF4), microRNA-10a (mir-10a), HOXA5 and HOXD4 and Rho GTPase activating protein 25 (ARHGAP25). [score:1]
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6
[+] score: 10
The unified set of top 10 unique miRNAs over the two pig breeds correspond to 15 unique miRNAs, 11 of which (ssc-let-7a-1/2-5p, ssc-let-7c-5p, ssc-let-7e-5p, ssc-miR-10a-5p, ssc-miR-10b-5p, ssc-miR-127-3p, ssc-miR-148a-3p, ssc-miR-199a-1/2-5p, ssc-miR-21-5p, ssc-miR-26a-5p, ssc-miR-125b-1-5p) had been frequently reported highly expressed in skeletal muscle during porcine prenatal and postnatal developmental stages. [score:4]
Study of Mai et al. revealed that ssc-let-7a-1/2-5p, ssc-miR-10a-5p, ssc-miR-127-3p, ssc-miR-148a-3p, ssc-miR-199a-1/2-5p, ssc-miR-26a-5p were the most highly expressed unique miRNAs over five porcine muscle developmental stages from 90 dpc to 7 y after birth [27]. [score:4]
For example, Qin et al. had reported that ssc-let-7a, ssc-miR-10a, ssc-miR-10b, ssc-miR-127, ssc-miR-148a, ssc-miR-21, ssc-miR-26a were the most abundant miRNAs during porcine skeletal muscle developmental stages from 35 days post coitum to postnatal day 180 [25]. [score:2]
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7
[+] score: 9
Moreover, 13 miRNAs were differentially expressed: 8 were upregulated (ssc-miR-132, ssc-miR-146b, ssc-miR-215, ssc-miR-371, ssc-miR-27a, ssc-miR-331-3p, ssc-miR-432-5p and ssc-miR-199a/b-3p), while 5 were down-regulated after PRV infection (ssc-mir-10a-5p, ssc-mir-148-3p, ssc-mir-219a, ssc-mir-374b-3p and ssc-miR-532-5p) (Fig 7). [score:9]
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8
[+] score: 8
All these 6 miRNAs were expressed in the in vivo profile, except miR-10a-5p which was expressed in the in vitro profile. [score:5]
Among the non-profile-shared miRNAs, there were 6 high expressed miRNAs (CN>1,000 counts): miR-99a-5p (11,178 counts), miR-10a-5p (3,570 counts), miR-133a (1,990 counts), miR-218b (1,887 counts), miR-9-3p (1,620 counts) and miR-129a (1,566 counts). [score:3]
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9
[+] score: 4
Similarly, miR-199a, miR-195, miR-10 and miR-23 expression were correlated with TG and haematological traits. [score:3]
For example, serum TG was correlated with miR-744, miR-199, miR-10, miR-23, miR-195 and miR-155, which were also correlated with erythrocyte-related traits (RBC, MCHC, HGB and MCV). [score:1]
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10
[+] score: 4
Other miRNAs from this paper: ssc-mir-122, ssc-mir-125b-2, ssc-mir-181b-2, ssc-mir-20a, ssc-mir-23a, ssc-mir-26a, ssc-mir-29b-1, ssc-mir-181c, ssc-mir-214, ssc-let-7c, ssc-let-7f-1, ssc-let-7i, ssc-mir-103-1, ssc-mir-107, ssc-mir-21, ssc-mir-29c, ssc-mir-30c-2, bta-mir-26a-2, bta-mir-29a, bta-let-7f-2, bta-mir-103-1, bta-mir-20a, bta-mir-21, bta-mir-26b, bta-mir-30d, bta-mir-499, bta-mir-99a, bta-mir-125b-1, bta-mir-126, bta-mir-181a-2, bta-mir-199a-1, bta-mir-30b, bta-mir-107, bta-mir-10a, bta-mir-127, bta-mir-142, bta-mir-181b-2, bta-mir-30e, bta-mir-92a-2, bta-let-7d, bta-mir-132, bta-mir-138-2, bta-mir-17, bta-mir-181c, bta-mir-192, bta-mir-199b, bta-mir-200a, bta-mir-200c, bta-mir-214, bta-mir-23a, bta-mir-29b-2, bta-mir-29c, bta-mir-455, bta-let-7g, bta-mir-10b, bta-mir-30a, bta-mir-200b, bta-let-7a-1, bta-let-7f-1, bta-mir-122, bta-mir-30c, bta-let-7i, bta-mir-25, bta-let-7a-2, bta-let-7a-3, bta-let-7b, bta-let-7c, bta-let-7e, bta-mir-103-2, bta-mir-125b-2, bta-mir-99b, ssc-mir-99b, ssc-mir-17, ssc-mir-30b, ssc-mir-199b, bta-mir-1-2, bta-mir-1-1, bta-mir-129-1, bta-mir-129-2, bta-mir-133a-2, bta-mir-133a-1, bta-mir-133b, bta-mir-135b, bta-mir-138-1, bta-mir-143, bta-mir-144, bta-mir-146b, bta-mir-146a, bta-mir-181d, bta-mir-190a, bta-mir-199a-2, bta-mir-202, bta-mir-206, bta-mir-211, bta-mir-212, bta-mir-223, bta-mir-26a-1, bta-mir-29d, bta-mir-30f, bta-mir-338, bta-mir-33a, bta-mir-33b, bta-mir-375, bta-mir-429, bta-mir-451, bta-mir-92a-1, bta-mir-92b, bta-mir-29e, bta-mir-29b-1, bta-mir-181a-1, bta-mir-181b-1, ssc-mir-133a-1, ssc-mir-1, ssc-mir-146b, ssc-mir-181a-1, ssc-mir-30a, bta-mir-199c, ssc-mir-206, ssc-let-7a-1, ssc-let-7e, ssc-let-7g, ssc-mir-133b, ssc-mir-29a, ssc-mir-30d, ssc-mir-30e, ssc-mir-199a-2, ssc-mir-499, ssc-mir-143, ssc-mir-10b, ssc-mir-103-2, ssc-mir-181a-2, ssc-mir-181b-1, ssc-mir-181d, ssc-mir-99a, ssc-mir-92a-2, ssc-mir-92a-1, ssc-mir-92b, ssc-mir-192, ssc-mir-142, ssc-mir-127, ssc-mir-202, ssc-mir-129a, ssc-mir-455, ssc-mir-125b-1, ssc-mir-338, ssc-mir-133a-2, ssc-mir-146a, bta-mir-26c, ssc-mir-30c-1, ssc-mir-126, ssc-mir-199a-1, ssc-mir-451, ssc-let-7a-2, ssc-mir-129b, ssc-mir-429, ssc-let-7d, ssc-let-7f-2, ssc-mir-29b-2, ssc-mir-132, ssc-mir-138, ssc-mir-144, ssc-mir-190a, ssc-mir-212, bta-mir-133c, ssc-mir-26b, ssc-mir-200b, ssc-mir-223, ssc-mir-375, ssc-mir-33b
MicroRNA-10 modulates Hox genes expression during Nile tilapia embryonic development. [score:3]
Sea louse Caligus rogercresseyi, which affects Chilean aquaculture, were studied during infestation in Atlantic salmon and the most abundant families were mir-10, mir-21, mir-30, mir-181, and let7 in skin, head and kidney (Valenzuela-Muñoz et al., 2017). [score:1]
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11
[+] score: 4
In addition, 10 other miRNAs (miR-378-1/-2-3p, miR-127-3p, miR-191-5p, miR-486-2-5p, miR-143-3p, miR-10a-5p, miR-148a-3p, miR-99a-5p, miR-30e-5p, and miR-199a-1/-2-5p) (Fig. 2) in the set of the top 10 most highly expressed unique miRNAs over the five muscle development stages are related to various cell proliferation, myogenesis, and apoptosis responses. [score:4]
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12
[+] score: 3
In this sense, variants expression followed two main patterns: according to those miRNAs with more than 1,000 total reads, they were distributed in those miRNAs with a strong predominant isomiR, such as Hsa-miR-200b-3p, Ssc-miR-125b, Ssc-miR-23b, Ssc-miR-23a, Ssc-miR-192, Ssc-miR-10b, Ssc-miR-126* and Ssc-miR-10a, and those miRNAs where there is not a really strong predominant isomiR, like Ssc-miR-126, Ssc-miR-99a, Hsa-miR-200c-3p, Ssc-miR-30d and Ssc-miR-125a (Table S3). [score:3]
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13
[+] score: 3
In the F3 library, ssc-miR-143, ssc-miR-145, ssc-miR-199b, ssc-miR-103, ssc-miR-191, ssc-miR-10a, ssc-miR-320a, ssc-miR-152, ssc-miR-23a and ssc-miR-23b were the dominant expressed miRNAs, with the number of reads ranging from 30,354 to 1,307,953. [score:3]
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14
[+] score: 3
Other miRNAs from this paper: hsa-let-7a-1, hsa-let-7a-2, hsa-let-7a-3, hsa-let-7b, hsa-let-7c, hsa-let-7d, hsa-let-7e, hsa-let-7f-1, hsa-let-7f-2, hsa-mir-17, hsa-mir-23a, hsa-mir-24-1, hsa-mir-24-2, hsa-mir-26a-1, hsa-mir-27a, hsa-mir-29a, hsa-mir-29b-1, hsa-mir-29b-2, hsa-mir-103a-2, hsa-mir-103a-1, hsa-mir-199a-1, hsa-mir-208a, hsa-mir-148a, hsa-mir-10a, hsa-mir-181a-2, hsa-mir-181c, hsa-mir-199a-2, hsa-mir-181a-1, hsa-mir-214, hsa-mir-221, hsa-let-7g, hsa-let-7i, hsa-mir-1-2, hsa-mir-23b, hsa-mir-27b, hsa-mir-125b-1, hsa-mir-128-1, hsa-mir-133a-1, hsa-mir-133a-2, hsa-mir-143, hsa-mir-125b-2, hsa-mir-126, hsa-mir-127, hsa-mir-206, hsa-mir-1-1, hsa-mir-128-2, hsa-mir-29c, hsa-mir-26a-2, hsa-mir-378a, hsa-mir-148b, hsa-mir-133b, hsa-mir-424, ssc-mir-125b-2, ssc-mir-148a, ssc-mir-23a, ssc-mir-24-1, ssc-mir-26a, ssc-mir-29b-1, ssc-mir-181c, ssc-mir-214, ssc-mir-27a, ssc-let-7c, ssc-let-7f-1, ssc-let-7i, ssc-mir-103-1, ssc-mir-128-1, ssc-mir-29c, hsa-mir-486-1, hsa-mir-499a, hsa-mir-503, hsa-mir-411, hsa-mir-378d-2, hsa-mir-208b, hsa-mir-103b-1, hsa-mir-103b-2, ssc-mir-17, ssc-mir-221, ssc-mir-133a-1, ssc-mir-1, ssc-mir-503, ssc-mir-181a-1, ssc-mir-206, ssc-let-7a-1, ssc-let-7e, ssc-let-7g, ssc-mir-378-1, ssc-mir-133b, ssc-mir-29a, ssc-mir-199a-2, ssc-mir-128-2, ssc-mir-499, ssc-mir-143, ssc-mir-486-1, ssc-mir-103-2, ssc-mir-181a-2, ssc-mir-27b, ssc-mir-24-2, ssc-mir-23b, ssc-mir-148b, ssc-mir-208b, ssc-mir-424, ssc-mir-127, ssc-mir-125b-1, hsa-mir-378b, hsa-mir-378c, ssc-mir-411, ssc-mir-133a-2, ssc-mir-126, ssc-mir-199a-1, ssc-mir-378-2, hsa-mir-378d-1, hsa-mir-378e, hsa-mir-378f, hsa-mir-378g, hsa-mir-378h, hsa-mir-378i, hsa-mir-499b, ssc-let-7a-2, ssc-mir-486-2, hsa-mir-378j, ssc-let-7d, ssc-let-7f-2, ssc-mir-29b-2, hsa-mir-486-2, ssc-mir-378b
Like ssc-miR-23b and 27b, it is reasonable to hypothesize that ssc-miR-10a, -140* and -9-1/-2 might act on earlier embryonic myogenesis, for they highly expressed at 35 dpc then decline dramatically. [score:3]
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15
[+] score: 2
MicroRNA-10a binds the 5′ UTR of ribosomal protein mRNAs and enhances their translation. [score:2]
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16
[+] score: 2
These include miR-214, miR-140, miR-150, miR-10, as well as miR-181. [score:1]
In the zebrafish, miR-214 can modulate hedgehog signaling, thus changing muscle cell fate [18], and miR-10 was shown to represses HoxB1a and HoxB3a, which are involved in patterning the anterior-posterior axis [19]. [score:1]
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17
[+] score: 2
Notably, prv-miR-10 and prv-miR-11 are each present in two copies in the PRV genome, and those located in the intron of LLT were designated as prv-miR-10-1 and prv-miR-11-1, while the homologous miRNAs in the terminal repeat region (TR) were named as prv-miR-10-2 and prv-miR-11-2. All 11 LLV intronic miRNA genes are interspersed and arranged in the same transcriptional orientation. [score:1]
Prv-miR-10 and prv-miR-11 are located in the repeat regions; therefore they both have two reverse copies. [score:1]
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18
[+] score: 2
Gastroenterology 139: 1654–1664, 1664 e1651 3 Lund AH 2010 miR-10 in development and cancer. [score:2]
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19
[+] score: 1
569 AMP miR-10, miR-126, let-7, miR-27, miR-450 9.860E-05–5.804E-04 0.789–0.730 ADP miR-15, miR-885, miR-322, miR-450, miR-338 1.316E-04–4.540E-03 0.781–0.636 ATP miR-15, miR-450, miR-210, miR-885, miR-451 4.811E-04–9.562E-03 0.737–0.593 Correlations between gene expression derived from post quality-filtered 17,820 mRNA probes and each phenotypic- trait were calculated for both Duroc and PiNN pigs. [score:1]
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